DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2528 and prepl

DIOPT Version :9

Sequence 1:	NP_610129.3	Gene:	CG2528 / 35435	FlyBaseID:	FBgn0032969	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_001139088.1	Gene:	prepl / 796680	ZFINID:	ZDB-GENE-090313-224	Length:	692	Species:	Danio rerio

Alignment Length:	778	Identity:	160/778 - (20%)
Similarity:	308/778 - (39%)	Gaps:	164/778 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRSDALVQS--PTDLSRSVEEASLRIVYPEARK----DGRFEEMIHGYKIKDVYRWLED-PDSV 58
            :||:..|.::  .|.|||...|....:...:.:|    :.||:..:|     .|:|...| ||:.
Zfish    15 LSRNVTLRRANIQTILSRLYSEGPTELSKAQLQKFKSQEQRFKRRLH-----SVHRKFADVPDNS 74

  Fly    59 DTQQFVNAQNNISQSFLERSAERENINSKLTKLWNFPKYGCPMRHGNYYYFFKNTGLQNQSVLMQ 123
            :.|    .|:::   :||   :.:.|            |...:.||                  :
Zfish    75 EFQ----GQHHV---YLE---DGKRI------------YRSTLGHG------------------K 99

  Fly   124 QKTLESPESIFLDTNSISSD----GTTAISHIKFSEDGAFMAYGLSESGSDWNK---IRIRNTKE 181
            |:|:|    :|      ::|    |..:|..::.|.....:|..:.:...:..:   ||:    .
Zfish   100 QETVE----VF------NADWGEGGYGSIQRVRLSPTETMLAATVKKDHHEKTRCMLIRL----N 150

  Fly   182 GIDLPE----ILEKVKFSNVSWTKDSKGFFYGRYTDQDGIFDGSETKLAENQKLYYHLLGESPHQ 242
            |:...:    :|:.|  .:..|..|            |.:|..::..|........||: :|..|
Zfish   151 GVSCTQRVMLVLDNV--LSFEWATD------------DVLFYSTQESLRSLHVFRLHLI-DSAVQ 200

  Fly   243 DILIAEFPEHPSWRFKTDISDCGKYLILSISHTVR-DNMLYYAELGSEEKNAFQLELKPIVDKFE 306
            ..|:.| .:.|  :|..::|......:::|:.:.: .:.:::.    :.|:.|  ....:....:
Zfish   201 TTLVYE-EKDP--KFFVEVSRSRDQRLVTINCSSKTSSEVWFV----DSKSPF--SFPSLTQSRQ 256

  Fly   307 ADFDYITNEGSNLYFHTNKDAPN--YRVIVIDVNNPAEEHWT---TPIPEHKKDVLEWAK--CVD 364
            ....|......|..|......|:  |:::...:.:|:..||.   :.:|......||..:  ||.
Zfish   257 PGLLYHVEHSDNSLFILANTGPDQEYQLLRASLASPSMPHWVPVFSAVPGTVIKDLELLQDHCVF 321

  Fly   365 GNKLVVCYNCDVKHILQARDLSTGK-------LIRQFGLD-----IGSINGISGKKSNSEIFYGF 417
            ..|...|.       ||.:.|:|.:       .:.|:..|     :|:::       .....:..
Zfish   322 TVKDSHCR-------LQIQTLTTKEPYQLNTLQLPQWACDLSPQRVGTVD-------RGSFSFLL 372

  Fly   418 SSFLSPGIIFYYDFAKPSEKPTVLREISLNLEGFSRDNYSVEQVFYKSTDDTDIP--MFIVQRKR 480
            ||.:.|.:.:.|  :...:|.::..:   :::..|...::..::...|.|.|.:|  :|.:....
Zfish   373 SSPVHPPVRYLY--SSKGQKLSITED---SIKHISIPEFNTTRLQATSHDGTMVPLTLFHMPAFS 432

  Fly   481 DIAEPRPCLLYGYGGFNYSLMPSFGILSLMFMDTFDG-VLAFPNLRGGGEYGMEWHNGGRMLSKQ 544
            ::.: .|.||:.||.:...|..:|.....|.::  || .||:.::|||||.|:.||..|.:|.||
Zfish   433 ELCK-APLLLHVYGAYGVDLNMTFSPEKRMMLE--DGWTLAYCHVRGGGERGLSWHRAGSVLQKQ 494

  Fly   545 NVFNDFQAAAEFLTKNNYTTKDRLAIQGASNGGLLVGACINQRPDLFGAAVAQVGVMDMLRFHK- 608
            ....|..|..:.|.:...:..|..|:...|.|.:|.||..||.|.|..|.:.|...:|:|...:
Zfish   495 RGVEDLAACIQTLHRLGVSGPDLTALTARSAGAILAGALCNQNPQLIRALILQAPFLDVLGTMQD 559

  Fly   609 ----FTIGHAWCSDYGNPDEKVHFANLIKFSPLHNVHIPLNPNQEYPSTLILTADHDDRVSPLHS 669
                .|:...  .::|:|..:.|..|:..:.|.||:.     .|.|||.||.....|.||.....
Zfish   560 TSLPLTLEEK--GEWGDPLIREHRDNIASYCPCHNIQ-----PQLYPSMLITAYSEDHRVPVSGV 617

  Fly   670 YKFVAALQEAVRYSEYQLN------PILLRVYTKAGHGAGKPTKMRISEATDIITFFKKTLNV 726
            .|||..|::|::....|::      .::|.:...|.|...:...:.::|:...:.|....|.:
Zfish   618 IKFVERLKKAIQMCTTQVDINARVPSVILDIQPGADHFGPEDFHLSLNESARQLAFLYTELGL 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2528	NP_610129.3	Peptidase_S9_N	28..442	CDD:280970	75/449 (17%)
CG2528	NP_610129.3	Peptidase_S9	516..727	CDD:278741	63/223 (28%)
prepl	NP_001139088.1	PtrB	<167..680	CDD:224684	121/563 (21%)
prepl	NP_001139088.1	Abhydrolase	454..681	CDD:304388	65/236 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840