Protein Alignment CG2528 and PREP

DIOPT Version :10

• Sequence 1: NP_610129.3
• Gene: CG2528 / 35435
• FlyBaseID: FBgn0032969
• Length: 731
• Species: Drosophila melanogaster
• Sequence 2: NP_002717.3
• Gene: PREP / 5550
• HGNCID: 9358
• Length: 710
• Species: Homo sapiens
• Alignment Length: 714
• Identity: 369/714 - (51%)
• Similarity: 473/714 - (66%)
• Gaps: 13/714 - (1%)

  Fly    23 LRIVYPEARKDGRFEEMIHGYKIKDVYRWLEDPDSVDTQQFVNAQNNISQSFLERSAERENINSK 87
            |.:.||:..:|....:..||:||.|.|.|||||||..|:.||.|||.|:..|||:...|.....:
Human     2 LSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKER 66

  Fly    88 LTKLWNFPKYGCPMRHGNYYYFFKNTGLQNQSVLMQQKTLESPESIFLDTNSISSDGTTAISHIK 152
            :|:|:::|||.|..:.|..|::|.|||||||.||..|.:||....:|||.|.:|.|||.|:....
Human    67 MTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYA 131

  Fly   153 FSEDGAFMAYGLSESGSDWNKIRIRNTKEGIDLPEILEKVKFSNVSWTKDSKGFFYGRYTDQDGI 217
            |||||.:.|||||.|||||..|:........:||::||:||||.::||.|.||.||..|..|||.
Human   132 FSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGK 196

  Fly   218 FDGSETKLAENQKLYYHLLGESPHQDILIAEFPEHPSWRFKTDISDCGKYLILSISHTVRD---- 278
            .||:||....:||||||:||....:|||.||||:.|.|....::||.|:|::|||    |:
Human   197 SDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSI----REGCDP 257

  Fly   279 -NMLYYAELGSEEKN-AFQLELKPIVDKFEADFDYITNEGSNLYFHTNKDAPNYRVIVIDVNNPA 341
             |.|:|.:|..|... |..|:...::|.||.::||:||||:...|.||:.:||||||.||..:|.
Human   258 VNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPE 322

  Fly   342 EEHWTTPIPEHKKDVLEWAKCVDGNKLVVCYNCDVKHILQARDLSTGKLIRQFGLDIGSINGISG 406
            |..|...:|||:||||||..||..|.||:||..|||:|||..||:||.|::.|.||:|||.|.||
Human   323 ESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSG 387

  Fly   407 KKSNSEIFYGFSSFLSPGIIFYYDFAKPSEKPTVLREISLNLEGFSRDNYSVEQVFYKSTDDTDI 471
            :|.::||||.|:||||||||::.|..|...:|.|.||::  ::|....:|...|:||.|.|.|.|
Human   388 QKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVT--VKGIDASDYQTVQIFYPSKDGTKI 450

  Fly   472 PMFIVQRKR-DIAEPRPCLLYGYGGFNYSLMPSFGILSLMFMDTFDGVLAFPNLRGGGEYGMEWH 535
            |||||.:|. .:....|..||||||||.|:.|::.:..|:|:....|:||..|:|||||||..||
Human   451 PMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWH 515

  Fly   536 NGGRMLSKQNVFNDFQAAAEFLTKNNYTTKDRLAIQGASNGGLLVGACINQRPDLFGAAVAQVGV 600
            .||.:.:|||.|:|||.|||:|.|..||:..||.|.|.|||||||.||.||||||||..:|||||
Human   516 KGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGV 580

  Fly   601 MDMLRFHKFTIGHAWCSDYGNPDEKVHFANLIKFSPLHNVHIPLNPNQEYPSTLILTADHDDRVS 665
            ||||:|||:||||||.:|||..|.|.||..|:|:||||||.:|...:.:|||.|:|||||||||.
Human   581 MDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVV 645

  Fly   666 PLHSYKFVAALQEAVRYSEYQLNPILLRVYTKAGHGAGKPTKMRISEATDIITFFKKTLNVDCI 729
            ||||.||:|.||..|..|..|.||:|:.|.|||||||||||...|.|.:|:..|..:.||||.|
Human   646 PLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWI 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2528	NP_610129.3	PreP	22..724	CDD:441114	364/707 (51%)
PREP	NP_002717.3	PreP	4..704	CDD:441114	363/705 (51%)