DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2528 and prep

DIOPT Version :9

Sequence 1:	NP_610129.3	Gene:	CG2528 / 35435	FlyBaseID:	FBgn0032969	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_001018589.1	Gene:	prep / 553791	ZFINID:	ZDB-GENE-050522-14	Length:	709	Species:	Danio rerio

Alignment Length:	709	Identity:	348/709 - (49%)
Similarity:	461/709 - (65%)	Gaps:	17/709 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 YPEARKDGRFEEMIHGYKIKDVYRWLEDPDSVDTQQFVNAQNNISQSFLERSAERENINSKLTKL 91
            ||...:|....:..||.||.|.|.|||||||..||.||||||.::..|||:...|:....::|:|
Zfish     5 YPNVYRDESVVDDYHGCKIPDPYSWLEDPDSEKTQAFVNAQNQLTLPFLEQCETRDLFKERMTEL 69

  Fly    92 WNFPKYGCPMRHGNYYYFFKNTGLQNQSVLMQQKTLESPESIFLDTNSISSDGTTAISHIKFSED 156
            :::|||.||.:.|:.|:.|.|||||||||:..|..|::..::|||.|:.|.|||.|:....||||
Zfish    70 YDYPKYSCPFKRGDRYFHFYNTGLQNQSVMYVQDNLDAEPTVFLDPNTFSEDGTVALRGYSFSED 134

  Fly   157 GAFMAYGLSESGSDWNKIRIRNTKEGIDLPEILEKVKFSNVSWTKDSKGFFYGRYTDQDGIFDGS 221
            |.|:|||.|.|||||.:||.......:.|.:.||:|||:.:|||.|.||.||..|.:|:|..||:
Zfish   135 GEFLAYGTSASGSDWVEIRFLRVDGAVLLEDRLERVKFTCMSWTHDGKGLFYNSYPEQEGKSDGT 199

  Fly   222 ETKLAENQKLYYHLLGESPHQDILIAEFPEHPSWRFKTDISDCGKYLILSISHTVRD-----NML 281
            ||....:||||||:||....||:|.||||:.|.|....::||.|:|::|||    |:     |.|
Zfish   200 ETSTNLHQKLYYHVLGTPQSQDVLCAEFPDEPKWMSGVEVSDDGRYVLLSI----REGCDPVNRL 260

  Fly   282 YYAELGSEEKNAFQLELKP---IVDKFEADFDYITNEGSNLYFHTNKDAPNYRVIVIDVNNPAEE 343
            :|.:|..|.:..  ..|.|   ::|.|:|:::|:||||:...|.||.:||.||:|.||...|:..
Zfish   261 WYCDLNEEPQGI--TGLLPWVKLIDNFDAEYEYVTNEGTVFTFKTNLEAPQYRLINIDFTQPSVS 323

  Fly   344 HWTTPIPEHKKDVLEWAKCVDGNKLVVCYNCDVKHILQARDLSTGKLIRQFGLDIGSINGISGKK 408
            .|...||:|.|||:.:|.|...:.|.||:..|||::|:...||:|:.||.|.||:|||.|.:|:|
Zfish   324 QWKELIPQHDKDVIVFATCTFSSFLFVCFLHDVKNVLKMFHLSSGEEIRTFPLDVGSIVGFTGRK 388

  Fly   409 SNSEIFYGFSSFLSPGIIFYYDFAKPSEKPTVLREISLNLEGFSRDNYSVEQVFYKSTDDTDIPM 473
            .:|||||.|:|||||.||::.|......:|.|.||::  ::||:..:|...||||.|.|.|.|||
Zfish   389 KDSEIFYSFTSFLSPAIIYHCDLTMEPLQPHVFREVT--VKGFNPADYQTTQVFYPSKDGTQIPM 451

  Fly   474 FIVQRKR-DIAEPRPCLLYGYGGFNYSLMPSFGILSLMFMDTFDGVLAFPNLRGGGEYGMEWHNG 537
            |||.:|. .:....|..||||||||.|:.||:.:..|:|:....||||..|:|||||||..||.|
Zfish   452 FIVHKKGIKMDGSHPAFLYGYGGFNISITPSYSVSRLIFIRHLGGVLAVANIRGGGEYGETWHKG 516

  Fly   538 GRMLSKQNVFNDFQAAAEFLTKNNYTTKDRLAIQGASNGGLLVGACINQRPDLFGAAVAQVGVMD 602
            |.:.:|||.|.|||.|||:|.|..||:..:|.|.|.|||||||.||:||||||||.|||||||||
Zfish   517 GMLANKQNCFTDFQCAAEYLIKEGYTSPKKLTINGGSNGGLLVAACVNQRPDLFGCAVAQVGVMD 581

  Fly   603 MLRFHKFTIGHAWCSDYGNPDEKVHFANLIKFSPLHNVHIPLNPNQEYPSTLILTADHDDRVSPL 667
            ||:||||||||||.:|:|..:.|..|..|||:|||||:.:|.....:||:.|:||.||||||.||
Zfish   582 MLKFHKFTIGHAWTTDFGCSEIKEQFDWLIKYSPLHNIQVPEGDGVQYPAVLLLTGDHDDRVVPL 646

  Fly   668 HSYKFVAALQEAVRYSEYQLNPILLRVYTKAGHGAGKPTKMRISEATDIITFFKKTLNV 726
            ||.|::|.||..:.....|.||:.:.:.||:||||||||...|.|..|...|..:.||:
Zfish   647 HSLKYIATLQNVIGQCPGQKNPLFIYIDTKSGHGAGKPTSKVIQEVADTYAFIARCLNL 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2528	NP_610129.3	Peptidase_S9_N	28..442	CDD:280970	192/421 (46%)
CG2528	NP_610129.3	Peptidase_S9	516..727	CDD:278741	122/211 (58%)
prep	NP_001018589.1	PreP	24..703	CDD:224422	339/686 (49%)
prep	NP_001018589.1	Peptidase_S9	481..706	CDD:278741	126/225 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594333
Domainoid	1	1.000	408	1.000	Domainoid score	I668
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2042
Inparanoid	1	1.050	762	1.000	Inparanoid score	I530
OMA	1	1.010	-	-		QHG63012
OrthoDB	1	1.010	-	-		D217404at33208
OrthoFinder	1	1.000	-	-		FOG0005219
OrthoInspector	1	1.000	-	-		otm25859
orthoMCL	1	0.900	-	-		OOG6_101804
Panther	1	1.100	-	-	O	PTHR42881
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3731
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910