DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1428 and CG15695

DIOPT Version :9

Sequence 1:	NP_610127.1	Gene:	CG1428 / 35433	FlyBaseID:	FBgn0032967	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_650920.3	Gene:	CG15695 / 42468	FlyBaseID:	FBgn0038832	Length:	725	Species:	Drosophila melanogaster

Alignment Length:	626	Identity:	149/626 - (23%)
Similarity:	256/626 - (40%)	Gaps:	112/626 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FVNTSVCHVSGQWKPTAFYSAIEPVNK----LRCRMTQLLTAITQDGSNFLEAKRISEDLSC--R 104
            ||::..|.:|   .|..|.:.|:.:.|    :.|..::.:..:..:.::.......:|:.:|  :
  Fly   157 FVHSPQCQMS---HPNPFANNIQHIYKKHSYIVCDKSRDMITVNYNVTDSTYRLHKNENSTCCFK 218

  Fly   105 YWLKSGHTRNHSGHYTAYGHFDLKRGATRKIKIG--------------TGEQIVRIRCSDKFKAS 155
            ..|::|.:.|                |..|.|:|              ....|...|.....|.|
  Fly   219 QILRAGTSAN----------------ADHKYKLGPCVEFHQDFLVPTEVSAMITYCRRPPFDKVS 267

  Fly   156 KYHDVLYFLSPPDPKL--MSTESSEKLSVMVLGIDSVSHMHFVRYFPLVMAFLENHPHTKFFGYS 218
            : .|...|:.|...::  .:|....:.||::.||||:|.|:.....|.:..:|.|....:..||:
  Fly   268 Q-KDAFSFVHPRKDQIENPTTPHRRRPSVLLWGIDSISRMNLELTMPRMYEYLNNQHWFELQGYN 331

  Fly   219 RVGLDANANLVPFLGGKSSRAAGSDILSDEKA-------WLWDSFKMEGYSTAYGED-------- 268
            ::|.:...||:..|.|.:...|.:. ...||.       ::|..||.:||:||:.||
  Fly   332 KMGDNTFPNLMAVLTGFNKTYANAR-CHPEKVRGLDACPFIWKDFKDKGYTTAFAEDWSKFSTFD 395

  Fly   269 -NAKGILSNRNGDKELPKSPVDFDLTPVIVEMNNHTRYSIDLKEMIHCTAGRKFQDVLRDFVLQL 332
             :::|..:          .|.|....|:::.:...... :...:|.:|...:...:.:.|..:|.
  Fly   396 YSSRGFFN----------PPTDVYGRPLVLAVEKELTI-LQRGQMPYCLGRKPASEYIYDMGVQF 449

  Fly   333 VPYMQGMPFFSFFWQSQGVQEYYEYAWHLD---LSYMMLLKKLLDADILNNTLLFLMSDHGLRAG 394
            ....:...||..||.:......:.....:|   :.||..|.|   ..|::||::...||||.|.|
  Fly   450 TMVNRNSTFFGMFWTNTFSHNDFSMPSAMDERMVKYMRTLDK---NGIMDNTIIIFFSDHGSRFG 511

  Fly   395 EYRMSLQGMKEESQPLMVAIYPEWLKRKYPLAVGNLESNAHSLITPYDLRETLADVIALGQLKDA 459
            ..|....|..||..|.:....|.|::.|||..:.||:.|.:.|.:|||:..||..::.|...||
  Fly   512 PLRNLDSGFVEERLPFIYIRVPRWIREKYPKLLRNLQMNKNRLTSPYDIHATLRHILELDTPKD- 575

  Fly   460 NIEVSMKRLQSHPPNRLPR--GI----SLFLPIPDHRTCDLAHIPSLFCFCRELTEVPTDDGLVL 518
                           :|||  |.    |:|..:...|.|..|.|...:|.|...::|||.|....
  Fly   576 ---------------KLPRPDGCSSCHSVFEEVDWSRNCSQAGIEDHWCACNSFSDVPTTDPSAR 625

  Fly   519 RSSRFMVESINQLI---KPFGQCRQLKLEMVLLAHFLDFGEESFVYELRLRVRTSPGNGVYEATV 580
            ..|..:||:||:.:   |...:|.:|||..:   ..:.....|..|.::|..:  ||:.::||||
  Fly   626 SMSTQLVEAINEYVASKKGTKRCSRLKLNRI---SSVQRRGNSNRYLIQLMAQ--PGDALFEATV 685

  Fly   581 RLSDVLLLTSP-----ISRVSHYLGQSHCIGDPDLQIFCLC 616
            .. |......|     |||:..|..:|.|....:.:.:|:|
  Fly   686 DW-DASAQRIPAQMPSISRLDTYAAKSRCSSVKETKKYCIC 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1428	NP_610127.1	DUF229	68..547	CDD:281053	123/528 (23%)
CG1428	NP_610127.1	ALP_like	180..453	CDD:293745	75/291 (26%)
CG15695	NP_650920.3	DUF229	180..656	CDD:281053	123/523 (24%)
CG15695	NP_650920.3	ALP_like	293..571	CDD:293745	75/292 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31599at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850