Protein Alignment tsh and TSHZ3

DIOPT Version :9

• Sequence 1: NP_523615.2
• Gene: tsh / 35430
• FlyBaseID: FBgn0003866
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: NP_065907.2
• Gene: TSHZ3 / 57616
• HGNCID: 30700
• Length: 1081
• Species: Homo sapiens
• Alignment Length: 1019
• Identity: 206/1019 - (20%)
• Similarity: 336/1019 - (32%)
• Gaps: 323/1019 - (31%)

  Fly    85 VPQSLPSQPPSMEAYL--HMVAAAAQQYGFPLAAAAAAGAGPRLPLPLANEAAAPFKLPPQ--AS 145
            :|:.....|....||:  .:.|||....|.......|.|           |.:|.:..|.:  |.
Human     1 MPRRKQQAPRRAAAYVSEELKAAALVDEGLDPEEHTADG-----------EPSAKYMCPEKELAR 54

  Fly   146 PTASSNNSEALDFRTNLYGRAESAEPPASEGEEEEFDDGANNPLDLSVGTRKRGHESEPQLGHIQ 210
            ...|..||.|.:|         |.....||....|..|   ...|...|:.|...|::    .:.
Human    55 ACPSYQNSPAAEF---------SCHEMDSESHISETSD---RMADFESGSIKNEEETK----EVT 103

  Fly   211 VKKMFKSDSPPANSVASPSASQLLPGVNPYLAAVAAANIFRAGQFPDWNSKNDLVVDPLEKMSDI 275
            |        |..::..|.|..|:....|.:|     :|.:       |::.|..:..|..:.::.
Human   104 V--------PLEDTTVSDSLEQMKAVYNNFL-----SNSY-------WSNLNLNLHQPSSEKNNG 148

  Fly   276 VKGGAS------GMGTKEKMHSSKATTPQAASQPPKSPVQPTPN---------QNSESGGGSGGG 325
            ....:|      |.|:.:...|:.|.|.|..||   |.:.|.|:         |:|:..|....|
Human   149 SSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQ---SRMLPEPSLFSTVQLYRQSSKLYGSIFTG 210

  Fly   326 AAGSGAVTKARHNIWQSHWQNKGVASSVFRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLP 390
            |                         |.|||..|..::.||..||.||.::.|
Human   211 A-------------------------SKFRCKDCSAAYDTLVELTVHMNETGH------------ 238

  Fly   391 SNNPQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWL 455
                ....:|.|     .|:|.::.|.                          |||    :::..
Human   239 ----YRDDNHET-----DNNNPKRWSK--------------------------PRK----RSLLE 264

  Fly   456 GKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNI-------------------------- 494
            .:|.|.|.::||||.||.||.||.:::.||.:|:||..:
Human   265 MEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVTPVAAKIIPATRKKASLELE 329

  Fly   495 ---------------LSQEQSISIKSGNANANSDAKESHNSLSSE----ESRTLSAVLTCKVCDK 540
                           :|.......|:.|.....:.:..|.:.:|.    |:|. |.:|.|..|..
Human   330 LPSSPDSTGGTPKATISDTNDALQKNSNPYITPNNRYGHQNGASYAWHFEARK-SQILKCMECGS 393

  Fly   541 AFNSLGDLSNHMAKNNHYAEPLLQSAGARKRPAPKKREKSLP-VRKLLEMKGGS----GTTQEDH 600
            :.::|.:|:.||....|:   :..:..|.|:..|.......| :..||:.|..|    .||....
Human   394 SHDTLQELTAHMMVTGHF---IKVTNSAMKKGKPIVETPVTPTITTLLDEKVQSVPLAATTFTSP 455

  Fly   601 SNEKTSVQGKPGLGPGGGDKNDAALFAERMRQ------------------YIT------GVKAPE 641
            ||...|:..|..:........:.|:..|:.:|                  |:|      ..|...
Human   456 SNTPASISPKLNVEVKKEVDKEKAVTDEKPKQKDKPGEEEEKCDISSKYHYLTENDLEESPKGGL 520

  Fly   642 EIAK-----VAAAQLLAKNKSPELVEQKNGG--SAKAA-----------GASSVLSAIEQMFTTS 688
            :|.|     |.:|...|:|.:|..     ||  |..||           |:|...:.::.||..|
Human   521 DILKSLENTVTSAINKAQNGTPSW-----GGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNS 580

  Fly   689 -FDTPPRHASL--PASSPSNSSTKNTSPVASSILKRLGIDETVDYNKPLIDTNDPYYQHYRYTSS 750
             ..:|.::.:|  |.||.::...|........::|:: .::.....:.:.:.:.......|.|.
Human   581 EIVSPTKNQTLVSPPSSQTSPMPKTNFHAMEELVKKV-TEKVAKVEEKMKEPDGKLSPPKRATP- 643

  Fly   751 ERSGSECSAEARPRLDAPTPEKQQQGGGHDEESSKPAIKQEREAESKPVKMEIKSEFVDEPNE-A 814
                |.||:|    :..|...:....||...:.:.|:..::...:..|:.         ||.| .
Human   644 ----SPCSSE----VGEPIKMEASSDGGFRSQENSPSPPRDGCKDGSPLA---------EPVENG 691

  Fly   815 EETSKMEAAVVNGSATNNNNNIVERSSPKTP----------------SSAASPQTRLLPP----- 858
            :|..|..|:.::||..     |:....|:.|                ..||.|....|.|
Human   692 KELVKPLASSLSGSTA-----IITDHPPEQPFVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLF 751

  Fly   859 ---RSPAESQRSVTP---KSPASSH-------------------KSYDGSSEGTKKF-PSDSLNA 897
               .|.||.....||   :|..:.|                   ||..|.|.|:... |:.:..|
Human   752 KMSNSLAEKAAVATPPPLQSKKADHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSVLLSPTSTAPA 816

  Fly   898 LSSMFDSLGSSGAGAN--SRAKLAAAAAAGGSESPENLTAGGNS 939
            .||...:...:.|..:  |.:.|...|.:..|:..:|||....|
Human   817 TSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTS 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tsh	NP_523615.2	zf-C2H2_2	<354..>382	CDD:289522	11/27 (41%)
		C2H2 Zn finger	356..378	CDD:275371	8/21 (38%)
		C2H2 Zn finger	468..490	CDD:275371	11/21 (52%)
		C2H2 Zn finger	535..557	CDD:275371	6/21 (29%)
TSHZ3	NP_065907.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	141..161		2/19 (11%)
		C2H2 Zn finger	216..238	CDD:275371	8/21 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..257		6/65 (9%)
		C2H2 Zn finger	277..299	CDD:275371	11/21 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..364		3/38 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	473..502		3/28 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	579..604		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	626..687		11/78 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..897		2/6 (33%)
		homeodomain	892..960	CDD:238039

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I5022
Isobase	1	0.950	-	0	Normalized mean entropy	S8361
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8503
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4785
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	8.020