DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tsh and tshz3b

DIOPT Version :9

Sequence 1:	NP_523615.2	Gene:	tsh / 35430	FlyBaseID:	FBgn0003866	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001182336.1	Gene:	tshz3b / 565811	ZFINID:	ZDB-GENE-100319-2	Length:	1147	Species:	Danio rerio

Alignment Length:	1003	Identity:	198/1003 - (19%)
Similarity:	312/1003 - (31%)	Gaps:	384/1003 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 EEFDDGANNPLDLSVGTRKRGHESEPQLGHIQVKK--MFKS-----DSPPA--NSVASPSASQLL 234
            ||..:.|  .||..|.......|.||.:.::...|  :.|.     |||||  :|....|.|.|
Zfish    18 EELKEAA--LLDEDVEGEDSALEEEPAMKYVCQDKDLLLKDRPGFHDSPPADFSSHEMDSESHL- 79

  Fly   235 PGVNPYLAAVAAANIFRAGQFPDWNSKND---LVVDPLEKMSDIVKGGASGMGTKEKMHSSKATT 296
                       :.:..|...|...:.||:   ...:||..:|..    :|.|.|.....||:..|
Zfish    80 -----------SESSDRMSDFESASVKNEEDSSAKEPLTSLSST----SSMMMTTTATPSSEEAT 129

  Fly   297 P-------------------------------QAASQPPKSPVQPTPNQNSESGGGSGGGAAGSG 330
            |                               |...:||:|....:.:.:|.|..||||......
Zfish   130 PLGPDSLEQMKAIYTSFLTNSYWSSLNLNLSQQPPEKPPRSHSSSSSSSSSSSSCGSGGYDWHQT 194

  Fly   331 AVTKARHNIWQSHWQNKGVAS-------------------------SVFRCVWCKQSFPTLEALT 370
            ||.|...|:.|:..:....||                         |.|||..|..::.||..||
Zfish   195 AVAKTLQNVSQNQSRLLHPASEPNLFSTVQLYRQSTKLYGSIFTGASKFRCKDCSAAYDTLVELT 259

  Fly   371 THMKDSKHCGVNVPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVKNAFQY 435
            .||.::.|.                            ::.|....|.|:.....|
Zfish   260 VHMNETGHY----------------------------RDDNHETDSEGTKRWSKP---------- 286

  Fly   436 RGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNI------ 494
                         |.:::...:|.|.|.::||||.||.||.||.:::.||.:|:||..:
Zfish   287 -------------RKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPV 338

  Fly   495 -----------------------------------LSQEQSISIKSGNANANSDAKESHNSLSSE 524
                                               ||....:..|:.|.....:.:..|.:.:|.
Zfish   339 TPVAAKIISSARKRAPIELELPSSPDSNGGTPKPSLSDPNDLLQKTPNPYITPNNRYGHQNGASY 403

  Fly   525 ----ESRTLSAVLTCKVCDKAFNSLGDLSNHMAKNNHYAE------------------------- 560
                |||. |.:|.|..|..:.::|.:|:.||....|:.:
Zfish   404 AWQFESRK-SQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAIKKGKPIMESMSTTAPNPIL 467

  Fly   561 ---------PLLQSAGARKRPAP--------------KKREKSLPVRKLLEMKGGSGTTQEDHSN 602
                     ||..:|.:...|||              ||.||.:.            .|:|.::|
Zfish   468 TNEDKVQSVPLAATAFSPPPPAPPPPSISPAIMPMEIKKEEKEVE------------CTRETNNN 520

  Fly   603 EKTSVQGKPGLGPGGGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAKNKSPELVEQKNGG 667
            :               ||..|.             ...:|..:|:       :|.|.|.|:....
Zfish   521 K---------------DKKAAE-------------SETDEKFEVS-------SKYPYLTEEDLEE 550

  Fly   668 SAKAAGASSVLSAIEQMFTTSFDT-----------PPRHASLPASSPSNSSTKNTSPVASSILKR 721
            |.|  |...:|.::|...|::.:.           |..||:....:....|.:|:.  .||.||.
Zfish   551 SPK--GGFDILKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNIMKLSLRNSG--KSSPLKY 611

  Fly   722 LGIDETV---DYNKPLID----TNDPYYQHYRYTSSE---------------------RSG---- 754
            :...|.:   ..::|||.    ...|:.::..:...|                     ||.
Zfish   612 MFSGEELLSPTKSQPLISPPSCQTSPFPKNNFHAMEELVKKVTEKVAKVEEKMRDPGARSSPLRR 676

  Fly   755 ---SECSAEA---------RPRLDAPTPEKQQQGGG--HDEESSKPAIKQERE-----AESKPVK 800
               |.||::|         :.|..|.|||  ..|||  |.|.:.....|:..|     ....||.
Zfish   677 TTPSPCSSDAGESARGESPKERRGAKTPE--TNGGGITHKESNGDALTKESLENGTDHVVKTPVS 739

  Fly   801 MEIKSEFV--DEPNEAEETSKMEA--AVVN---GSATNNNNNIVERSSPKTPSSAASPQTRLLPP 858
            ....|..:  |.|.|....:.:.|  :|:|   |.|          :.|..||  ..|.:.|...
Zfish   740 TLCSSTAIITDHPPEQPFVNPLSALQSVMNVHLGKA----------AKPALPS--LDPMSMLFKM 792

  Fly   859 RSPAESQRSVTPKSPASSHKSYD-------------------GSSEGTKKFPSDSLNALSSMFDS 904
            .:....:.:|...:|:.:.|:.|                   |.|:.:....|.:|::.:|...|
Zfish   793 SNSLAEKAAVAASTPSQTKKTNDHLDRYFYHINNDQPIDLTKGKSDKSNSLGSAALSSSTSTPTS 857

  Fly   905 LGSSGAGANSRAKLAAAAAAGGSESPEN 932
            :..|.....::|..|.|:....|...||
Zfish   858 ISPSSTITMAKASSAVASFMSNSPLREN 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tsh	NP_523615.2	zf-C2H2_2	<354..>382	CDD:289522	11/27 (41%)
		C2H2 Zn finger	356..378	CDD:275371	8/21 (38%)
		C2H2 Zn finger	468..490	CDD:275371	11/21 (52%)
		C2H2 Zn finger	535..557	CDD:275371	6/21 (29%)
tshz3b	NP_001182336.1	C2H2 Zn finger	245..267	CDD:275371	8/21 (38%)
		C2H2 Zn finger	306..328	CDD:275371	11/21 (52%)
		homeodomain	935..1003	CDD:238039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4973
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6467
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.080