DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tsh and tshz3a

DIOPT Version :9

Sequence 1:	NP_523615.2	Gene:	tsh / 35430	FlyBaseID:	FBgn0003866	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_686844.3	Gene:	tshz3a / 558522	ZFINID:	ZDB-GENE-100322-1	Length:	1021	Species:	Danio rerio

Alignment Length:	931	Identity:	189/931 - (20%)
Similarity:	298/931 - (32%)	Gaps:	301/931 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 PPQASPTASSNNSEALDFRTNLYGRAESAEPPASEGEEEEFDDGAN--NPLDLS--VGTRKRGHE 201
            |.:|:...|.|..|.: .:|.   ..||..|...|..:.|.|.|.:  ||:|..  ..:...||:
Zfish     9 PKRAAAYDSENGKETV-VQTE---GTESVCPVTKENPQGENDLGEDFKNPMDEQDCSASELSGHD 69

  Fly   202 ----------SEP-------QLGHIQVKKMFKSDSPPANSVASPSASQLLPGV------NPYLAA 243
                      |||       .:.:.:..|.|..|| ..|||....:.:.:..:      |||.:
Zfish    70 VDSESHISESSEPTSDAESTTIKNEEATKDFIKDS-SENSVCITDSLEQMKAIYKSFLNNPYWS- 132

  Fly   244 VAAANIFRAGQFPDWNSKNDLVVD-PLEKMSDIVKGGASGMGTKEKMHSSKATTPQAASQPPKSP 307
                       |...||......: |...........:.|....:...|:.|.|.|..||.|...
Zfish   133 -----------FLSLNSPQSYADEQPASSSGSSSSNSSPGRTCYDWHQSAIAKTLQQVSQKPPIA 186

  Fly   308 VQPT-------PNQNSESGGGSGGGAAGSGAVTKARHNIWQSHWQNKGVASSVFRCVWCKQSFPT 365
            ::|:       ..|:::..|....||                         |.|.|..|..::.|
Zfish   187 LEPSIFSTVQLYRQSTKLYGSIFTGA-------------------------SKFHCKSCSAAYDT 226

  Fly   366 LEALTTHMKDSKHCGVNVPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVK 430
            |..||.||.::.|.                            ::.||   .|.|.|..|.|.
Zfish   227 LLDLTVHMNETDHY----------------------------RDDNL---ESASKSGKSWSK--- 257

  Fly   431 NAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNIL 495
                         |||    :::...:|.|.|.::|:||.||.||.||.:::.||.:|:||..:.
Zfish   258 -------------PRK----RSLLEMEGKEDAQKVLRCMYCGHSFESLQDLSVHMIKTKHYQKVP 305

  Fly   496 SQEQSISI----------------------------KSGNANANSDAKESHNSLSSEE------- 525
            .:|...:|                            :|.|.....|..:.::..:.::
Zfish   306 LREPRTAIAAKVVSSFRKRVPVELDVAKSLHTTEQTRSPNEGHTRDILQMYSEQNIKDDLDQKTT 370

  Fly   526 SRTL---SAVLTCKVCDKAFNSLGDLSNHMAKNNHYAEPLLQSAGARKRPAPK-KREKS------ 580
            ||.:   |..|.|..|..:.:||..||.||....|:.:.........|.|.|| |.|||
Zfish   371 SRGVHFKSQNLKCLECGISHDSLQQLSAHMMLTGHFLKVTQSLQKTDKTPHPKSKSEKSLSETTC 435

  Fly   581 ---LPVRKLLEMKGGSGTTQEDHSNEKTSVQGKPGLGPGGGDKNDAALFAERMRQYITGVKAPEE 642
               |...::||....|.....||
Zfish   436 SSPLAATRILESSSYSSIATGDH------------------------------------------ 458

  Fly   643 IAKVAAAQLLAKNKSPELVEQKNGGSAKAAGASSVLSAIEQMFTTSFDTPPRHASLPASSPSNSS 707
                       |||:.|:..||:..|.::|..:.|...:.....|.:.|             ...
Zfish   459 -----------KNKTQEITSQKSSESKESANVNDVRQKLGPSAKTDYLT-------------EDD 499

  Fly   708 TKNTSPVASSILKRLGIDETVDYNKPLIDTNDPYYQHYRYTSSERSGSECSAEARPRLDAP--TP 770
            .|.:..:...|||.|....|...||  .....|.:..|:   |..:..:.....:|.|..|  ..
Zfish   500 LKESPKMDFDILKSLENTVTSAINK--AQKGAPSWGGYQ---SIHAAYQLRNHLKPALHNPGYIS 559

  Fly   771 EKQQQGGGHDEES--SKPAIKQEREAESKPVKMEIKSEFVDE------PNEAEETSKMEAAVVNG 827
            ..:|.....:.:|  ....|....:..|....:::..  |||      ..:||...|::.....|
Zfish   560 SLKQSSSSQEVQSLDKSNLIPPSTQPSSSSTTVQVSE--VDELEMNVTEKDAEVDRKLKDLNGQG 622

  Fly   828 SATNNNNNIVERS----SPKTPSSAASPQTRLLPPRSPAESQRSVTPKSPASSHKSYDGSS---- 884
            |......|:..:|    || :|.|..:..:::...::..:..|. ..:.|.|:...||.||
Zfish   623 SPHPQLLNLKGKSLMLKSP-SPESTVTSMSKITEGKTEEKETRK-HKQDPTSTSNLYDDSSLLSA 685

  Fly   885 EGTKKFPSDS-LNALSSMFD-SLGSSGAG--------------ANSRAKLAAAAAAGG------- 926
            :...|.||.| |:||.|:.: .||.:...              :||.|:.||.|...|
Zfish   686 QPEPKQPSVSPLSALQSVMNLHLGKAAKPVRPVQDPMSMLLRMSNSMAERAALAGPSGHSTKLSQ 750

  Fly   927 ---------SESPENLTAGGN 938
                     .:.|.:|:.|.|
Zfish   751 LHSNCHEICRDQPIDLSKGKN 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tsh	NP_523615.2	zf-C2H2_2	<354..>382	CDD:289522	10/27 (37%)
		C2H2 Zn finger	356..378	CDD:275371	8/21 (38%)
		C2H2 Zn finger	468..490	CDD:275371	11/21 (52%)
		C2H2 Zn finger	535..557	CDD:275371	8/21 (38%)
tshz3a	XP_686844.3	C2H2 Zn finger	217..239	CDD:275371	8/21 (38%)
tshz3a	XP_686844.3	C2H2 Zn finger	278..300	CDD:275371	11/21 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4973
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D411087at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6467
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4785
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.120