DRSC/TRiP Functional Genomics Resources

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Protein Alignment tsh and tshz1

DIOPT Version :9

Sequence 1:NP_523615.2 Gene:tsh / 35430 FlyBaseID:FBgn0003866 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001036211.1 Gene:tshz1 / 369196 ZFINID:ZDB-GENE-030820-3 Length:1158 Species:Danio rerio


Alignment Length:894 Identity:181/894 - (20%)
Similarity:298/894 - (33%) Gaps:308/894 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 KLPPQASPTASSNNSEA-------------LDFRTNLYGRAESAEPPASEGEEEEFDDGANNPLD 190
            :|..|.||.::..|.:|             .||::.      |::....:.|.|:.|..|...|.
Zfish    75 QLSYQNSPLSNGTNPDAGYGSPLSDTSDHLADFKST------SSKEGQDKEEVEDMDTDAKLSLQ 133

  Fly   191 LSVGTRKRGHE---SEPQLGHIQVKKMFKSDSPPANSVASPSASQLLPGVNPYLAAVAAANIFRA 252
            .|:...|..:.   |:.....| .|.:.||....|:|:.|.|:|.  .|.|      :.||    
Zfish   134 DSLAQMKAVYANLISDASWSSI-TKDIMKSKQVSASSINSTSSSH--KGNN------SVAN---- 185

  Fly   253 GQFPDWNSKNDLVVDPLEKMSDIVKGGASGMGTKEKMHSSKATTPQAASQPPKSPVQPTPNQNSE 317
                             ...|.|...|||   :.....:|..|....:|...|:......|..:.
Zfish   186 -----------------SHASTIASSGAS---SSSNASASTKTNVTQSSNSTKATTLTNANNGTI 230

  Fly   318 SGGGSGGGAAG--SGAVTKA-RHNIW------------QSHWQNKGV------ASSVFRCVWCKQ 361
            :|..|||.|..  ..|:.|. :|..:            |.:.||..:      .:|.|||..|..
Zfish   231 NGANSGGVAYDWHQAALAKTLQHTPYHLMPEPSLFSTVQLYRQNNKLYGPVFTGASKFRCKDCSA 295

  Fly   362 SFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPS 426
            ::.||..||.||.::.|.                            ::.|               
Zfish   296 AYDTLVGLTVHMNETGHY----------------------------RDDN--------------- 317

  Fly   427 ANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHY 491
               |:..:.||...:. |||    :::...:|.|.|.::||||.||.||.||.:::.||.:|:||
Zfish   318 ---KDKEEDRGKKWSK-PRK----RSLMEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHY 374

  Fly   492 TNILSQE---------------------------QSISIKSGNANANS----DAKESHNSLSSE- 524
            ..:..:|                           .|||...|...|.:    |.|.|:..:::. 
Zfish   375 QKVPLKEPMPALASKLVPSTKKRVFQDLMSPCSPDSISSTPGIPLAETAPTKDPKISNPYVTANN 439

  Fly   525 --------------ESRTLSAVLTCKVCDKAFNSLGDLSNHMAKNNHY----------------- 558
                          |:|. :.:|.|..|..:.::|..|:.||....|:                 
Zfish   440 RYGYQNGASYTWQFEARK-AQILKCMECGSSHDTLQQLTAHMMVTGHFLKVTNSASKKGKQLVFD 503

  Fly   559 --AEPLLQS----AGARKRPAPK-KREKSLPV-------RKLLEMKGGSGTTQEDHSNEKTSVQG 609
              .|..:||    ....:.|||. |.:...|:       ||.||.:      :.:...||...| 
Zfish   504 PVVEEKIQSIPLPPTTTRLPAPAIKSQPDSPIHPSIMDDRKELEEE------KFEEPEEKKIKQ- 561

  Fly   610 KPGLGPGGGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAKNKSPELVEQKNGGSAKAAGA 674
                     :|.|.   :||:          |:..|::..:.|   :..:|.|...||.......
Zfish   562 ---------EKEDP---SERV----------EKSEKLSHYKYL---REEDLEESPKGGLDILKSL 601

  Fly   675 SSVLSAIEQMFTTSFDTPPRHASLPASSPSNSSTKNTSPVASSI----------LKRLGIDETVD 729
            .:.:|:......|...|...:.|:.|:.....|.|::.|...|:          ||.|..|.:..
Zfish   602 ENTVSSAISKAQTGTPTWGGYPSIHAAYQLQGSVKSSIPAIQSVQIQPTFNASSLKSLTSDSSTL 666

  Fly   730 YNKPLIDTNDPYYQH---------YRYTS------------SERSGSECSAE-----ARPRLDAP 768
            .:.|...:..|.::.         .:.|.            :||:....:||     .:.|.|.|
Zfish   667 IHSPSSPSPPPNHKSNVLAMEELVEKVTGKIPSKKDRDEKLTERNSKHLTAELPSPVLKERKDLP 731

  Fly   769 TPEKQQQGGGHDEESSKPAIK--QEREAESKPVKM-EIKSEFVDEPNEAEETSKMEAAVVNGSAT 830
            .|          ::.:||...  .:::.|..||:. |.|....|.|.: ..|..::..|.||.  
Zfish   732 KP----------DDLTKPTKNGTVDKDLEHTPVREGEYKESHADNPIK-NGTDALKTQVSNGC-- 783

  Fly   831 NNNNNIVERSSPKTPSSAASPQTRLLPPRSPAES---------QRSVTP 870
             .|..|:...||:.|         |:.|.|..:|         .::|:|
Zfish   784 -GNLGIITDHSPEQP---------LVNPLSALQSIMNTHLGKASKTVSP 822

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tshNP_523615.2 zf-C2H2_2 <354..>382 CDD:289522 11/27 (41%)
C2H2 Zn finger 356..378 CDD:275371 8/21 (38%)
C2H2 Zn finger 468..490 CDD:275371 11/21 (52%)
C2H2 Zn finger 535..557 CDD:275371 6/21 (29%)
tshz1NP_001036211.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 70..126 11/56 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 170..228 17/89 (19%)
C2H2 Zn finger 290..312 CDD:275371 8/21 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..341 8/81 (10%)
C2H2 Zn finger 351..373 CDD:275371 11/21 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 405..425 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 516..573 17/85 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..681 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 693..748 11/64 (17%)
homeodomain 964..1032 CDD:238039
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170580298
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 101 1.000 Inparanoid score I4973
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm6467
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12487
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4785
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
77.070

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