DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tsh and Tshz1

DIOPT Version :9

Sequence 1:	NP_523615.2	Gene:	tsh / 35430	FlyBaseID:	FBgn0003866	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_038953268.1	Gene:	Tshz1 / 307217	RGDID:	1311684	Length:	1083	Species:	Rattus norvegicus

Alignment Length:	965	Identity:	185/965 - (19%)
Similarity:	315/965 - (32%)	Gaps:	330/965 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 EPPASEGEEEEFDDGA-------------------------NNPLDLSVGTRKRGH-----ESEP 204
            |..|:|.:||..:||.                         |:|:..:. .:..|:     |...
  Rat    20 ELKAAEIDEEHVEDGGLSLDIQESEFVCNEETEIKEAQSYQNSPVSTAT-NQDAGYGSPFSEGSD 83

  Fly   205 QLGHIQ--VKKMFKSDSPPANSVASPSASQLLPGVNPYLAAVAA--ANIFRAGQFPDWNSKNDLV 265
            ||.|.:  ..:..|.:....:||:.|..|         ||.:.|  ||:|...   .|:|   |.
  Rat    84 QLAHFKSSTSREEKEEPQCPDSVSYPQDS---------LAQIKAVYANLFSES---CWSS---LA 133

  Fly   266 VDPLEKMSDIVKGGASGMGTKEKMHSSKATTPQAASQPPKSPVQPTPNQNSESGGGSGGGAAGSG 330
            :| |:|                   ||..|:...|||...|...|||..::.|...:....|.:.
  Rat   134 LD-LKK-------------------SSSTTSNNDASQKESSTPTPTPPTSTASTACTTATTAITS 178

  Fly   331 AVTKARHNIWQSH-------WQNKGVA-------------------------------------S 351
            ..|...|:...|:       |....:|                                     :
  Rat   179 CSTSTSHSSTTSNNSSSGYDWHQAALAKTLQQTSSYGLLPEPSLFSTVQLYRQNNKLYGSVFTGA 243

  Fly   352 SVFRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHS 416
            |.|||..|..::.||..||.||.::.|.                            ::.|..|.|
  Rat   244 SKFRCKDCSAAYDTLVELTVHMNETGHY----------------------------RDDNRDKDS 280

  Fly   417 SGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEM 481
            ..:.....|                       |.:::...:|.|.|.::||||.||.||.||.::
  Rat   281 EKTKRWSKP-----------------------RKRSLMEMEGKEDAQKVLKCMYCGHSFESLQDL 322

  Fly   482 TKHMQETQHY---------------------------------------TNILSQEQSISIKSGN 507
            :.||.:|:||                                       |::...|.:...|:.|
  Rat   323 SVHMIKTKHYQKVPLKEPVPAITKLVPSTKKRALQDLASPCSPEPTGMATDVALSESAKDQKTAN 387

  Fly   508 ANANSDAKESHNSLSSE----ESRTLSAVLTCKVCDKAFNSLGDLSNHMAKNNHYAEPLLQSAGA 568
            .....:.:..:.:.:|.    |:|. :.:|.|..|..:.::|..|:.||....|:.:....::..
  Rat   388 PYVTPNNRYGYQNGASYTWQFEARK-AQILKCMECGSSHDTLQQLTAHMMVTGHFLKVTTSASKK 451

  Fly   569 RKR----PAPKKREKSLP-------------VRKLLEMKGGSGTTQEDHSNEKTSVQGKPGLGPG 616
            .|:    |..:::.:|:|             ::|..:...||..::|....||...:.|  ..|.
  Rat   452 GKQLVLDPVVEEKIQSIPLPPTTHTRLPASSIKKQPDSPAGSVASEEKKEPEKEKEKEK--APPT 514

  Fly   617 GGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAKNKSPELVEQKNGGSAKAAGASSVLSAI 681
            .||       .||..:..| ..|.|:....|..|.|   :..:|.:...||       ..:|.::
  Rat   515 AGD-------TERKIKEET-EDATEKFEPTALYQYL---REEDLDDSPKGG-------VDILKSL 561

  Fly   682 EQMFTTSFDT-----------PPRHAS--LPAS-SPSNSSTKNTS---PVASSILKRLGIDETVD 729
            |...:|:...           |..||:  ||.: .|..|:.::..   ..|||:......:....
  Rat   562 ENTVSTAISKAQNGAPSWGGYPSIHAAYQLPGTVKPLQSAVQSVQIQPSYASSVKSLSSTEHNAL 626

  Fly   730 YNKPLIDTNDPYYQHYRYTSSERSGSECSAEARPRLDAPTPEKQQQGGGHDEESS-----KPAIK 789
            .:.|...|..|:          :|......|...::......|:::.....|::|     .|..|
  Rat   627 LHSPGSLTPPPH----------KSNVSAMEELVEKVTGKVSVKKEERPTEKEKASPVKAISPVAK 681

  Fly   790 QER------EAESKPVKM-------EIKSEFVDEPNEAEETSKMEAAVVNGSATNNNNNIVERSS 841
            :.:      |..|||.|.       :.|.|...:.:....|..::|.|.||.   :|..|:...|
  Rat   682 ENKDLPKSEETGSKPQKKGSDLETGKAKKESTVDAHTPNGTEPLKAKVTNGC---SNLGIITDHS 743

  Fly   842 PK----TPSSA------------ASPQTRLLPPR------SPAESQRSVTPKSPASSHKS----- 879
            |:    .|.||            :.|.:..|.|.      |.:...:.|.|.:||....:
  Rat   744 PEPSFINPLSALQSIMNTHLGKVSKPVSPSLDPLAMLYKISNSMLDKPVYPTTPAKQADAIDRYY 808

  Fly   880 YDGSSEGTKKFPSDSLNALSSMFDSLGSSGAGANSRAKLAAAAAAGGSESPENLT 934
            |:.|.:......|.:...:|.:.|::.|         .|..:|....|:..:|||
  Rat   809 YENSDQPIDLTKSKNKPLVSGVADAVSS---------PLRESALMDISDMVKNLT 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tsh	NP_523615.2	zf-C2H2_2	<354..>382	CDD:289522	11/27 (41%)
		C2H2 Zn finger	356..378	CDD:275371	8/21 (38%)
		C2H2 Zn finger	468..490	CDD:275371	11/21 (52%)
		C2H2 Zn finger	535..557	CDD:275371	6/21 (29%)
Tshz1	XP_038953268.1	C2H2 Zn finger	248..270	CDD:275371	8/21 (38%)
		C2H2 Zn finger	309..331	CDD:275371	11/21 (52%)
		homeodomain	892..960	CDD:238039
		zf-C2H2_2	976..>1066	CDD:403839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5308
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8976
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.150