DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tsh and Tshz3

DIOPT Version :9

Sequence 1:	NP_523615.2	Gene:	tsh / 35430	FlyBaseID:	FBgn0003866	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_006540028.2	Gene:	Tshz3 / 243931	MGIID:	2442819	Length:	1203	Species:	Mus musculus

Alignment Length:	963	Identity:	189/963 - (19%)
Similarity:	306/963 - (31%)	Gaps:	313/963 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 ESAEPPASEGEEEEFDDGANNPLDLSVGTRKRGHESEPQLG---------HIQVKKMFKSDSPPA 222
            |..|....|.||||.::......:......:...|.:|::.         .::...:.:.|..|.
Mouse    91 EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEQKPKVAGFILAYVSDELKAAALVEDDVEPE 155

  Fly   223 NSVA--SPSASQLLP------GVNPYLAAVAA----------ANIF----RAGQFPDWNSKND-- 263
            ...|  .|||..:.|      ....|..:.||          ::|.    |...|...:.||:
Mouse   156 EQAADGEPSAKYMCPEKELSKACPSYQNSPAAEFSSHEMDSESHISETSDRMADFESSSIKNEEE 220

  Fly   264 -----------LVVDPLEKMSDIVKGGASG---MGTKEKMHSSKATTPQAASQPPKSPVQPTPNQ 314
                       :|.|.||:|..:.....|.   ......:|                  ||:...
Mouse   221 TKEVQVPLEDTIVSDSLEQMKAVYNNFLSNSYWSNLNLNLH------------------QPSSEN 267

  Fly   315 N--SESGGGSGGGAAGSG-------AVTKARHNIWQS--------------HWQNKGVASSV--- 353
            |  |.|...|...:.|||       |:.|....:.|:              :.|:..:..|:
Mouse   268 NGGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVSQNRMLPEPSLFSTVQLYRQSSKLYGSIFTG 332

  Fly   354 ---FRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKH 415
               |||..|..::.||..||.||.::.|                ....:|.|     .|:|.::.
Mouse   333 ASKFRCKDCSAAYDTLVELTVHMNETGH----------------YRDDNHET-----DNNNPKRW 376

  Fly   416 SSGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGE 480
            |.                          |||    :::...:|.|.|.::||||.||.||.||.:
Mouse   377 SK--------------------------PRK----RSLLEMEGKEDAQKVLKCMYCGHSFESLQD 411

  Fly   481 MTKHMQETQHYTNI-----------------------------------------LSQEQSISIK 504
            ::.||.:|:||..:                                         ||.......|
Mouse   412 LSVHMIKTKHYQKVPLKEPVTPVAAKIIPAARKKPSLELELPSSPDSTGGTPKATLSDASDALQK 476

  Fly   505 SGNANANSDAKESHNSLSSE----ESRTLSAVLTCKVCDKAFNSLGDLSNHMAKNNHYAEPLLQS 565
            :.|.....:.:..|.:.:|.    |:|. |.:|.|..|..:.::|.:|:.||....|:   :..:
Mouse   477 NSNPYITPNNRYGHQNGASYAWHFEARK-SQILKCMECGSSHDTLQELTAHMMVTGHF---IKVT 537

  Fly   566 AGARKRPAPKKREKSLP-VRKLLEMKGGS----GTTQEDHSNEKTSVQGKPGLGPGGGDKNDAAL 625
            ..|.|:..|.......| :..||:.|..|    .||....||...||..|
Mouse   538 NSAMKKGKPIMETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASVSPK--------------- 587

  Fly   626 FAERMRQYITGVKA-PEEIAKVAAAQLLAKNKSPELVEQKNGGSAK------------AAGASSV 677
            .|..:::.:...|| |:|..|        :.:.|...|:|...|:|            ..|...:
Mouse   588 LAVEIKKEVDKEKAVPDEKPK--------EREKPSEEEEKYDISSKYHYLTENDLEESPKGGLDI 644

  Fly   678 LSAIEQMFTTSFDT-----------PPRHAS--LP-------ASSPSNSSTK---NTSPVASSIL 719
            |.::|...|::.:.           |..||:  ||       .||..::..|   ..|.:.|...
Mouse   645 LKSLENTVTSAINKAQNGTPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNSEIVSPTK 709

  Fly   720 KRLGIDETVDYNKPLIDTNDPYYQHYRYTSSERSGSECSAEARPRLDAPTPEKQQQGGGHDEESS 784
            .:..:........|:..||        :.:.|....:.:.:.     |...||.::..|......
Mouse   710 TQTLVSPPSSQTSPMPKTN--------FHAMEELVKKVTEKV-----AKVEEKMKEPEGKLSPPK 761

  Fly   785 KPAIKQEREAESKPVKMEIKSE--FVDEPNE-------AEETSKMEAAVVNGSATNNNNNIVERS 840
            :.........:|:|:|||..|:  |..:.|.       .:|.|.....|.||           :.
Mouse   762 RATPSPCSSEQSEPIKMEASSDGSFKSQENSPSPPRDACKEASPSAEPVENG-----------KE 815

  Fly   841 SPKTPSSAASPQTRLL---PPRSPAESQRSVTPKSPASSHKSYDGSSEGTKKFPS-DSLNALSSM 901
            ..|..|...|..|.::   ||..|     .|.|.|...|..:...........|: |.::.|..|
Mouse   816 LVKPLSGGLSGSTAIITDHPPEQP-----FVNPLSALQSVMNIHLGKAAKPSLPALDPMSMLFKM 875

  Fly   902 FDSLGSSGAGANSRAKLAAAAAAG--------GSESPENLTAG----GNSLAA 942
            .:||....|.| :...|.|..|..        .::.|.:||.|    |.||.:
Mouse   876 SNSLAEKAAVA-TPPPLQAKKAEHLDRYFYHVNNDQPIDLTKGKSDKGCSLGS 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tsh	NP_523615.2	zf-C2H2_2	<354..>382	CDD:289522	11/27 (41%)
		C2H2 Zn finger	356..378	CDD:275371	8/21 (38%)
		C2H2 Zn finger	468..490	CDD:275371	11/21 (52%)
		C2H2 Zn finger	535..557	CDD:275371	6/21 (29%)
Tshz3	XP_006540028.2	C2H2 Zn finger	338..360	CDD:275371	8/21 (38%)
		C2H2 Zn finger	399..421	CDD:275371	11/21 (52%)
		homeodomain	1014..1082	CDD:238039
		zf-met	1163..1186	CDD:403930
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I4987
Isobase	1	0.950	-	0	Normalized mean entropy	S8361
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8737
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4785
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	8.020