DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tsh and Tshz2

DIOPT Version :9

Sequence 1:	NP_523615.2	Gene:	tsh / 35430	FlyBaseID:	FBgn0003866	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_006499486.2	Gene:	Tshz2 / 228911	MGIID:	2153084	Length:	1050	Species:	Mus musculus

Alignment Length:	941	Identity:	188/941 - (19%)
Similarity:	311/941 - (33%)	Gaps:	328/941 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 NSEALDFRTNLYGRAESAEPPAS---------------------------EGEEEEFDDGANNPL 189
            |||.|...|..:|     .||.|                           |.||||.|.|:....
Mouse     4 NSEGLGRETTRHG-----VPPVSRHLEAYARITKHGYAQEEVLKEEEEIKEEEEEEEDSGSVAQH 63

  Fly   190 DLSVGTRKRGHESEPQLGHIQVKKMFKSDSPPANSVASPSASQLLPGVNPYLAAVAAANIFRAGQ 254
            ..|..|   |.:.|.:.|..| |..|...:.|.:.:::..|
Mouse    64 QSSNDT---GTDEELETGPEQ-KGYFSCQNSPGSHLSNQDA------------------------ 100

  Fly   255 FPDWNSKNDLVVDPLEKMSDIVKGGASGMGTKEKMHSSKATTPQAASQPPKSPVQP--------- 310
                 ....|:.|..:::||:            |....:..:.:.|:..||.|.:|
Mouse   101 -----ENESLLSDASDQVSDV------------KSVCGRDVSDKKANTHPKLPSEPHNCMDKMTA 148

  Fly   311 ----------------------TPNQNSESGGGSGGGAAG--SGAVTKA-RHNI----------- 339
                                  :..:|.::...||.....  ..|::|: :.|:
Mouse   149 VYANILSDSYWSGLGLGFKLSNSERRNCDTRNSSGKNDFDWHQDALSKSLQQNLPSRSVSKPSLF 213

  Fly   340 --WQSHWQNKGVASSV------FRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPQP 396
              .|.:.|:..:..||      |||..|..::.||..||.||.::.|.
Mouse   214 SSVQLYRQSSKLCGSVFTGASRFRCRQCSAAYDTLVELTVHMNETGHY----------------- 261

  Fly   397 QHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQ 461
                       |:.|.:|......|...|.   |.|||                     ....|.
Mouse   262 -----------QDDNRKKDKLRPTSYSKPR---KRAFQ---------------------DMDKED 291

  Fly   462 AMQILKCMRCGESFRSLGEMTKHMQETQHYTNILSQEQSISIKSG------------NANANSDA 514
            |.::||||.||:||.||.:::.||.:|:||..:..:|...:|.|.            |...:.|:
Mouse   292 AQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDS 356

  Fly   515 KESH--NSLSSEESRTL------------------------SAVLTCKVCDKAFNSLGDLSNHMA 553
            ....  :|.||::|..|                        |.:|.|..|..:.::|..|:.||.
Mouse   357 TTGSLADSFSSQKSANLQLPSNSRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMM 421

  Fly   554 KNNHYAEPLLQSAGARK------RPAPKKREKSL---PVRKLLEMKGGSGTTQE-DHSNEKTSVQ 608
            ...|:.:  :.|:.::|      .|...::.:||   |..:.|..|..|.:..| ..|..:...:
Mouse   422 VTGHFLK--VTSSASKKGKQLVLDPLAVEKMQSLSETPNSESLAPKPSSNSPSECTASTTELKKE 484

  Fly   609 GKPGLGPGGGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAKNKSPEL------VEQKNGG 667
            .|...|.|..|:.              |||:.:      ....|.|...|.:      .|....|
Mouse   485 SKKEKGEGIEDEQ--------------GVKSED------YEDSLQKPLDPTIKYQYLREEDLEDG 529

  Fly   668 SAKAAGASSVLSAIEQMFTTSFDTPPRHA-------SLPASSPSNSSTKNTSPVASSILK-RLGI 724
            |   .|...:|.::|...||:.:.....|       |:.|:...:..||....:.|.||: |..:
Mouse   530 S---KGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPMAMGSQILQIRPNL 591

  Fly   725 DETVDYNKPL-----------IDTNDPYYQHYRYTSSERSG--SECSAEARPRLDAPTPEKQQQG 776
            ...:   :|:           :.|:...|...:..:.::..  .:|..|: |..:| |...|.:|
Mouse   592 ANKL---RPIAPKWKGMPLGPVPTSLALYTQVKKETEDKDEVVKQCGKES-PHEEA-TSFSQPEG 651

  Fly   777 GGHDEESSK---PAIKQEREAESKPVKMEIKSEFVDEPNEAEETSKMEAAVVNGSATNN------ 832
                |..||   |:  :.|:||..|:|.|.|.: .::|...|..|    ::.||.|..|
Mouse   652 ----ESFSKIEPPS--ESRKAEPCPLKEEEKPQ-KEKPEPLEPVS----SLTNGCAPANHTPALP 705

  Fly   833 ------------NNNIVERSSP------KTPSSAASP---QTRLLPPRSPAESQRSVTPKSPASS 876
                        ||::.:.:.|      .:|:|:.||   ::.|.....|..|..|..|.:..:.
Mouse   706 SINPLSALQSVLNNHLGKATEPLRSPSCSSPNSSTSPVFHKSSLHVVDKPVISPTSTRPAASVAR 770

  Fly   877 HKSYDGSSEGTKKFPSDSLNALSSMFDSLGS 907
            |..::.:.:......|.|..|.||...|..|
Mouse   771 HYLFENTDQPIDLTKSKSKRAESSQAQSCTS 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tsh	NP_523615.2	zf-C2H2_2	<354..>382	CDD:289522	11/27 (41%)
		C2H2 Zn finger	356..378	CDD:275371	8/21 (38%)
		C2H2 Zn finger	468..490	CDD:275371	11/21 (52%)
		C2H2 Zn finger	535..557	CDD:275371	6/21 (29%)
Tshz2	XP_006499486.2	C2H2 Zn finger	238..260	CDD:275371	8/21 (38%)
		C2H2 Zn finger	298..320	CDD:275371	11/21 (52%)
		homeodomain	858..926	CDD:238039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836798
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CNCF
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I4987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8737
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4785
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.970