DRSC/TRiP Functional Genomics Resources

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Protein Alignment tsh and TSHZ2

DIOPT Version :9

Sequence 1:NP_523615.2 Gene:tsh / 35430 FlyBaseID:FBgn0003866 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_775756.3 Gene:TSHZ2 / 128553 HGNCID:13010 Length:1034 Species:Homo sapiens


Alignment Length:885 Identity:179/885 - (20%)
Similarity:285/885 - (32%) Gaps:289/885 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 EEEEFDDGANNPLDLSVGTRKRGHESEPQLGHIQVKKMFKSDSPPANSVASPSASQLLPGVNPYL 241
            ||||.|.|:...|.   |....|.:.|.:.|..| |..|...:.|.:.:::..|           
Human    30 EEEEEDSGSVAQLQ---GGNDTGTDEELETGPEQ-KGCFSYQNSPGSHLSNQDA----------- 79

  Fly   242 AAVAAANIFRAGQFPDWNSKNDLVVDPLEKMSDIVKGGASGMGTKEKMHSSKATTPQAASQPPKS 306
                              ....|:.|..:::|||  ....|....:|...:....|..|......
Human    80 ------------------ENESLLSDASDQVSDI--KSVCGRDASDKKAHTHVRLPNEAHNCMDK 124

  Fly   307 PVQPTPNQNSE---SGGGSGGGAAGS---GAVTKARHNIWQSHWQNKGVASSV------------ 353
            ......|..|:   ||.|.|...:.|   ...|:...|.....|....::.|:            
Human   125 MTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGSNKSDFDWHQDALSKSLQQNLPSRSVSKP 189

  Fly   354 -------------------------FRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNN 393
                                     |||..|..::.||..||.||.::.|.              
Human   190 SLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHY-------------- 240

  Fly   394 PQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKG 458
                          |:.|.:|......|...|.   |.|||                     ...
Human   241 --------------QDDNRKKDKLRPTSYSKPR---KRAFQ---------------------DMD 267

  Fly   459 VEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNILSQEQSISIKS------------------ 505
            .|.|.::||||.||:||.||.:::.||.:|:||..:..:|...:|.|                  
Human   268 KEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCS 332

  Fly   506 -----GN-ANANSDAKESHNSLSSEE--------------SRTLSAVLTCKVCDKAFNSLGDLSN 550
                 |: |::.|..|.::..|||..              ....|.:|.|..|..:.::|..|:.
Human   333 PDSTTGSFADSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTT 397

  Fly   551 HMAKNNHYAEPLLQSAGARKRPAPKKREKSLPVRKLL--EMKGGSGTTQEDHSNEKTSVQGKPGL 613
            ||....|:.: :..||        .|:.|.|.:..|.  :|:..|.....|....|         
Human   398 HMMVTGHFLK-VTSSA--------SKKGKQLVLDPLAVEKMQSLSEAPNSDSLAPK--------- 444

  Fly   614 GPGGGDKNDAALFAERMRQYITGVKAPEEIA---KVAAAQ----LLAKNKSPEL------VEQKN 665
             |.....:|.......:::. :..:.|||.:   ||..::    .|.|...|.:      .|...
Human   445 -PSSNSASDCTASTTELKKE-SKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLE 507

  Fly   666 GGSAKAAGASSVLSAIEQMFTTSFDTPPRHA-------SLPASSPSNSSTKNTSPVASSILK-RL 722
            .||   .|...:|.::|...||:.:.....|       |:.|:...:..||...|:.|.:|: |.
Human   508 DGS---KGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRP 569

  Fly   723 GIDETVDYNK-----------PLIDTND---PYYQHYRYT-SSERSGSECSAEARPRLDAPTPEK 772
            .:.     ||           ||:....   ||.|..:.: ..:.:..||..|        :|.:
Human   570 NLT-----NKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECGKE--------SPHE 621

  Fly   773 QQQGGGHDE-----ESSKPAIKQEREAESKPVKMEIKSEFVDEPNEAEETSKME--AAVVNGSAT 830
            :.....|.|     :|..|  .:.::.|..|:|.|.|  .:.|.:|.|:...:|  :|:.||.|.
Human   622 EASSFSHSEGDSFRKSETP--PEAKKTELGPLKEEEK--LMKEGSEKEKPQPLEPTSALSNGCAL 682

  Fly   831 NN------------------NNNIVERSSPKTPSSAASPQTRLL-------------PPRSPAES 864
            .|                  ||::.:.:.|....|.:||.:..:             |..||| |
Human   683 ANHAPALPCINPLSALQSVLNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPA-S 746

  Fly   865 QRSVTPKSPASSHKSYDGSSEGTKKFPSDSLNALSSMFDS 904
            .||.:    .|....::.|.:......|.|..|.||...|
Human   747 TRSAS----VSRRYLFENSDQPIDLTKSKSKKAESSQAQS 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tshNP_523615.2 zf-C2H2_2 <354..>382 CDD:289522 11/27 (41%)
C2H2 Zn finger 356..378 CDD:275371 8/21 (38%)
C2H2 Zn finger 468..490 CDD:275371 11/21 (52%)
C2H2 Zn finger 535..557 CDD:275371 6/21 (29%)
TSHZ2NP_775756.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..90 18/92 (20%)
C2H2 Zn finger 217..239 CDD:275371 8/21 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 239..265 10/77 (13%)
C2H2 Zn finger 277..299 CDD:275371 11/21 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 432..496 13/74 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..676 18/89 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..789 6/20 (30%)
homeodomain 842..910 CDD:238039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1014..1034
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146849
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_2CNCF
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 98 1.000 Inparanoid score I5022
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8503
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12487
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4785
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.970

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