DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tsh and Tshz1

DIOPT Version :9

Sequence 1:NP_523615.2 Gene:tsh / 35430 FlyBaseID:FBgn0003866 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001074769.1 Gene:Tshz1 / 110796 MGIID:1346031 Length:1084 Species:Mus musculus


Alignment Length:989 Identity:193/989 - (19%)
Similarity:311/989 - (31%) Gaps:367/989 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 EPPASEGEEEEFDDGA-------------------------NNPLDLSVGTRKRGH-----ESEP 204
            |..|:|.:||..:||.                         |:|:..:. .:..|:     |...
Mouse    20 ELKAAEIDEEHAEDGGLSLDIQESEFACNEETEIKEAQSYQNSPVSTAT-NQDAGYGSPFSEGSD 83

  Fly   205 QLGHIQ--VKKMFKSDSPPANSVASPSASQLLPGVNPYLAAVAA--ANIFRAGQFPDWNSKNDLV 265
            ||.|.:  ..:..|.:|...:||:.|..|         ||.:.|  ||:|...   .|:|   |.
Mouse    84 QLAHFKSSSSREEKEESQCPDSVSYPQDS---------LAQIKAVYANLFSES---CWSS---LA 133

  Fly   266 VDPLEKMSDIVKGGASGMGTKEKMHSSKATTPQAASQPPKSPVQPTPNQNSESGGGSGGGAAGSG 330
            :| |:|                   |:.||:...|||...|...|||..::.|...:....|.:.
Mouse   134 LD-LKK-------------------SNSATSNNDASQKESSTPTPTPPTSTASTACTTATTAITS 178

  Fly   331 AVTKARHNIWQSH-------WQNKGVA-------------------------------------S 351
            ..|...|:...|:       |....:|                                     :
Mouse   179 CSTSTSHSSTTSNSSSSGYDWHQAALAKTLQQTSSYGLLPEPSLFSTVQLYRQNNKLYGSVFTGA 243

  Fly   352 SVFRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHS 416
            |.|||..|..::.||..||.||.::.|.                            ::.|..|.|
Mouse   244 SKFRCKDCSAAYDTLVELTVHMNETGHY----------------------------RDDNRDKDS 280

  Fly   417 SGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEM 481
            ..:.....|                       |.:::...:|.|.|.::||||.||.||.||.::
Mouse   281 EKTKRWSKP-----------------------RKRSLMEMEGKEDAQKVLKCMYCGHSFESLQDL 322

  Fly   482 TKHMQETQHYTNILSQEQSISI----KSGNANANSD------------AKESHNSLSSEESRTL- 529
            :.||.:|:||..:..:|...:|    .|....|..|            |.|...|.|:::.:|. 
Mouse   323 SVHMIKTKHYQKVPLKEPVPAITKLVPSTKKRALQDLASPCSPEPTGVATEVALSESAKDQKTAN 387

  Fly   530 -------------------------SAVLTCKVCDKAFNSLGDLSNHMAKNNHYAEPLLQSAGAR 569
                                     :.:|.|..|..:.::|..|:.||....|:.:....::...
Mouse   388 PYVTPNNRYGYQNGASYTWQFEARKAQILKCMECGSSHDTLQQLTAHMMVTGHFLKVTTSASKKG 452

  Fly   570 KR----PAPKKREKSLP-------------VRKLLEMKGGSGTTQEDHSNEKTSVQGKPGLGPGG 617
            |:    |..:::.:|:|             ::|..:...||..::|....||...:.|  ..|..
Mouse   453 KQLVLDPVVEEKIQSIPLPPTTHTRLPASSIKKQPDSPAGSVASEEKKEPEKEKEKEK--APPAA 515

  Fly   618 GDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAK---NKSPE----------------LVEQ 663
            ||       |||..:..| ..|.|:....|..|.|.:   :.||:                :.:.
Mouse   516 GD-------AERKIKEET-EDATEKFEPTALYQYLREEDLDDSPKGGVDILKSLENTVSTAISKA 572

  Fly   664 KNG-----------------GSAKAAGAS--------SVLSAIEQMFTTSFD---------TPPR 694
            :||                 |:.|...::        |..|:::.:.:|..:         |||.
Mouse   573 QNGAPSWGGYPSIHAAYQLPGTVKPLQSAVQSVQIQPSYASSVKSLSSTEHNALLHSPGSLTPPP 637

  Fly   695 HAS----------------------LPASSPSNSSTKNTSPVASSILKRLGIDETVDYNKPLIDT 737
            |.|                      .|.....:|..|..||||..             ||.|..|
Mouse   638 HKSNVSAMEELVEKVTGKVSIKKEERPTEKEKSSPVKAISPVAKE-------------NKDLPKT 689

  Fly   738 NDPYYQHYRYTSSERSGSECSAEARPRLDAPTPE-------KQQQGGGH----DEESSKPAIKQE 791
            .:...:..:..|...:|   .|:....|||.||.       |...|.||    .:.|.:|:....
Mouse   690 EETGSKPQKKGSDSETG---KAKKESTLDAHTPNGTEPLKAKVTNGCGHLGIITDHSPEPSFINP 751

  Fly   792 REA-----------ESKPVK---------MEIKSEFVDEPNEAEETSKMEAAVVNGSATNNNNNI 836
            ..|           .||||.         .:|.:..:|:|......:|...|:......|::..|
Mouse   752 LSALQSIMNTHLGKVSKPVSPSLDPLAMLYKISNSMLDKPVYPTTPAKQADAIDRYYYENSDQPI 816

  Fly   837 VERSSPKTPSSAASPQTRLLPPRSPAESQRS---------VTPKSPASSHKSYDGSSEGTKKFPS 892
            ....|...|..:........|.|..|....|         :||||...|..|....::|:..  .
Mouse   817 DLTKSKNKPLVSGVADAVSSPLRESALMDISDMVKNLTGRLTPKSSTPSTVSEKSDADGSSF--E 879

  Fly   893 DSLNALSSMFDSLG 906
            ::|:.||.:....|
Mouse   880 EALDELSPVHKRKG 893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tshNP_523615.2 zf-C2H2_2 <354..>382 CDD:289522 11/27 (41%)
C2H2 Zn finger 356..378 CDD:275371 8/21 (38%)
C2H2 Zn finger 468..490 CDD:275371 11/21 (52%)
C2H2 Zn finger 535..557 CDD:275371 6/21 (29%)
Tshz1NP_001074769.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..108 11/59 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..167 9/26 (35%)
C2H2 Zn finger 248..270 CDD:275371 8/21 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..298 6/79 (8%)
C2H2 Zn finger 309..331 CDD:275371 11/21 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..534 18/76 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 653..728 19/90 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 855..879 7/25 (28%)
homeodomain 892..960 CDD:238039 1/2 (50%)
zf-C2H2_2 976..>1067 CDD:372293
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836796
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 99 1.000 Inparanoid score I4987
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8737
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12487
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
66.040

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