DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tsh and TSHZ1

DIOPT Version :9

Sequence 1:	NP_523615.2	Gene:	tsh / 35430	FlyBaseID:	FBgn0003866	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001295139.1	Gene:	TSHZ1 / 10194	HGNCID:	10669	Length:	1077	Species:	Homo sapiens

Alignment Length:	927	Identity:	192/927 - (20%)
Similarity:	324/927 - (34%)	Gaps:	295/927 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 EGEEEEFDDGANNPLDLSVGTRKRGH-----ESEPQLGHIQ--VKKMFKSDSPPANSVASPSASQ 232
            |.|.:|.....|:|:. |...:..|:     ||..||.|.:  ..:..|.|....:||:.|..|
Human    50 ETEIKEAQSYQNSPVS-SATNQDAGYGSPFSESSDQLAHFKGSSSREEKEDPQCPDSVSYPQDS- 112

  Fly   233 LLPGVNPYLAAVAA--ANIFRAGQFPDWNSKNDLVVDPLEKMSDIVKGGASGMGTKEKMHSSKAT 295
                    ||.:.|  ||:|...   .|:|   |.:       |:.|.|::..........|.|.
Human   113 --------LAQIKAVYANLFSES---CWSS---LAL-------DLKKSGSTTSTNDASQKESSAP 156

  Fly   296 TPQAASQPPKSPVQ---PTPNQNSESGGGSGGGAAGSGAVTKARHNIW----------------- 340
            ||    .||..||.   ||.:..|.|...|...::.:...:.:.:: |
Human   157 TP----TPPTCPVSTTGPTTSTPSTSCSSSTSHSSTTSTSSSSGYD-WHQAALAKTLQQTSSYGL 216

  Fly   341 ----------QSHWQNKGVASSV------FRCVWCKQSFPTLEALTTHMKDSKHCGVNVPPFGNL 389
                      |.:.||..:..||      |||..|..::.||..||.||.::.|.
Human   217 LPEPSLFSTVQLYRQNNKLYGSVFTGASKFRCKDCSAAYDTLVELTVHMNETGHY---------- 271

  Fly   390 PSNNPQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVKNAFQYRGDPPTPLPRKLVRGQNVW 454
                              ::.|..|.|..:.....|                       |.:::.
Human   272 ------------------RDDNRDKDSEKTKRWSKP-----------------------RKRSLM 295

  Fly   455 LGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNILSQEQSISI---------------- 503
            ..:|.|.|.::||||.||.||.||.:::.||.:|:||..:..:|...:|
Human   296 EMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVPAITKLVPSTKKRALQDLA 360

  Fly   504 -----------------------KSGNANANSDAKESHNSLSSE----ESRTLSAVLTCKVCDKA 541
                                   |:.|.....:.:..:.:.:|.    |:|. :.:|.|..|..:
Human   361 PPCSPEPAGMAAEVALSESAKDQKAANPYVTPNNRYGYQNGASYTWQFEARK-AQILKCMECGSS 424

  Fly   542 FNSLGDLSNHMAKNNHYAEPLLQSAGARKR----PAPKKREKSLP-------------VRKLLEM 589
            .::|..|:.||....|:.:....::...|:    |..:::.:|:|             ::|..:.
Human   425 HDTLQQLTAHMMVTGHFLKVTTSASKKGKQLVLDPVVEEKIQSIPLPPTTHTRLPASSIKKQPDS 489

  Fly   590 KGGSGTTQEDHSNEKTSVQGKPGLGPGGGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAK 654
            ..||.|::|....||.    ||   |..||       ||::::     ::.:.:.|...:.|.
Human   490 PAGSTTSEEKKEPEKE----KP---PVAGD-------AEKIKE-----ESEDSLEKFEPSTLY-- 533

  Fly   655 NKSPELVEQKNGGSAKAAGASSVLSAIEQMFTTSFDT-----------PPRHAS--LPAS---SP 703
               |.|.|:....|.|  |...:|.::|...:|:...           |..||:  ||.:   .|
Human   534 ---PYLREEDLDDSPK--GGLDILKSLENTVSTAISKAQNGAPSWGGYPSIHAAYQLPGTVKPLP 593

  Fly   704 SNSSTKNTSPVASSILKRLGIDETVDYN----KPLIDTNDPYYQHYRYTSSERSGSECSAEARPR 764
            :...:....|..:..:|.|   .:.::|    .|...|..|:..:  .::.|....:.:.:...:
Human   594 AAVQSVQVQPSYAGGVKSL---SSAEHNALLHSPGSLTPPPHKSN--VSAMEELVEKVTGKVNIK 653

  Fly   765 LDAPTPEKQQQGGGH---------------DEESSKPAIKQEREAESKPVKMEIKSEFVDEPNEA 814
            .:...|||::.....               :|.|.||. |:..|||:...|.|...: |..||
Human   654 KEERPPEKEKSSLAKAASPIAKENKDFPKTEEVSGKPQ-KKGPEAETGKAKKEGPLD-VHTPN-- 714

  Fly   815 EETSKMEAAVVNGSATNNNNNIVERSSPK----TPSSA------------ASPQTRLLPPR---- 859
             .|..::|.|.||.   ||..|:...||:    .|.||            :.|.:..|.|.
Human   715 -GTEPLKAKVTNGC---NNLGIIMDHSPEPSFINPLSALQSIMNTHLGKVSKPVSPSLDPLAMLY 775

  Fly   860 --SPAESQRSVTPKSP-----ASSHKSYDGSSEGTKKFPSDSLNALSSMFDSLGSSGAGANSRAK 917
              |.:...:.|.|.:|     |.....|:.|.:......|.:...:||:.||:.|         .
Human   776 KISNSMLDKPVYPATPVKQADAIDRYYYENSDQPIDLTKSKNKPLVSSVADSVAS---------P 831

  Fly   918 LAAAAAAGGSESPENLT 934
            |..:|....|:..:|||
Human   832 LRESALMDISDMVKNLT 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tsh	NP_523615.2	zf-C2H2_2	<354..>382	CDD:289522	11/27 (41%)
		C2H2 Zn finger	356..378	CDD:275371	8/21 (38%)
		C2H2 Zn finger	468..490	CDD:275371	11/21 (52%)
		C2H2 Zn finger	535..557	CDD:275371	6/21 (29%)
TSHZ1	NP_001295139.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..109		16/59 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..195		14/59 (24%)
		C2H2 Zn finger	248..270	CDD:275371	8/21 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..298		6/79 (8%)
		C2H2 Zn finger	309..331	CDD:275371	11/21 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..549		24/107 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..720		17/77 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	848..873		1/1 (100%)
		homeodomain	886..954	CDD:238039
		zf-C2H2_2	970..>1060	CDD:289522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146848
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I5022
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8503
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4785
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	7.070