Protein Alignment tsh and Tshz2

DIOPT Version :10

• Sequence 1: NP_523615.2
• Gene: tsh / 35430
• FlyBaseID: FBgn0003866
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: XP_038962660.1
• Gene: Tshz2 / 100911757
• RGDID: 6490867
• Length: 1053
• Species: Rattus norvegicus
• Alignment Length: 892
• Identity: 186/892 - (20%)
• Similarity: 308/892 - (34%)
• Gaps: 258/892 - (28%)

  Fly   156 LDFRTNLYGRAE--SAEPPASEGEEEEFDDGANNPLDLSVGTRKRGHESEPQLGHIQVKKMFKSD 218
            |:.|...|.:.|  ..|....|.|||:.|.|:   :....|:...|.:.|.:.|..| |..|...
  Rat    31 LELRRGGYAQEEVLKEEEEIKEEEEEDEDSGS---VAQHQGSNDTGTDEELETGPEQ-KGYFSCQ 91

  Fly   219 SPPANSVASPSA--SQLLPGVNPYLAAVAAANIFRAGQFPD--WNSKNDLVVDP---LEKMSDIV 276
            :.|.:.:::..|  ..||...:..::.:.:.   .:...||  .|....|..:|   ::||:.:.
  Rat    92 NSPGSHLSNQDAENESLLSDASDQVSDIKSV---CSRDAPDKKANPHAKLPSEPHNCMDKMTAVY 153

  Fly   277 KGGA-----SGMGTKEKMHSSK---ATTPQAASQP---------PKSPVQPTPNQNSESGGGSGG 324
            ....     ||:|...|:.:|:   ..|...:|:.         .||..|..|
  Rat   154 ANILSDSYWSGLGLGFKLSNSERRNCDTRNGSSKNDFDWHQDALSKSLQQNLP------------ 206

  Fly   325 GAAGSGAVTK-ARHNIWQSHWQNKGVASSV------FRCVWCKQSFPTLEALTTHMKDSKHCGVN 382
                |.:|:| :..:..|.:.||..:..||      |||..|..::.||..||.||.::.|.
  Rat   207 ----SRSVSKPSLFSSVQLYRQNSKMCGSVFTGASRFRCRQCSAAYDTLVELTVHMNETGHY--- 264

  Fly   383 VPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVKNAFQYRGDPPTPLPRKL 447
                                     |:.|.:|......|...|.   |.|||
  Rat   265 -------------------------QDDNRKKDKLRPTSYSKPR---KRAFQ------------- 288

  Fly   448 VRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNILSQEQSISIKSG------ 506
                    ....:.|.::||||.||:||.||.:::.||.:|:||..:..:|...:|.|.
  Rat   289 --------DMDKDDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVAPAK 345

  Fly   507 ------NANANSDAKESH--NSLSSEESRTL------------------------SAVLTCKVCD 539
                  |...:.|:....  :|.||::|..|                        |.:|.|..|.
  Rat   346 KRVFDVNRPCSPDSTTGSLADSFSSQKSANLQLPSNSRYGYQNGASYTWQFEACKSQILKCMECG 410

  Fly   540 KAFNSLGDLSNHMAKNNHYAEPLLQSAGARK------RPAPKKREKSL---PVRKLLEMKGGSGT 595
            .:.::|..|:.||....|:.:  :.|:.::|      .|...::.:||   |..:.|..|..|.:
  Rat   411 SSHDTLQQLTTHMMVTGHFLK--VTSSASKKGKQLVLDPLAVEKMQSLSESPNSESLAPKPSSNS 473

  Fly   596 TQEDHSN----EKTSVQGKPGLGPGGGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAKNK 656
            ..|..::    :|.|.:.|       |:.|:..          .|||..|      ....|.|..
  Rat   474 PSESTASATELKKESKKEK-------GEINEDE----------QGVKNEE------YEDALQKPL 515

  Fly   657 SPEL------VEQKNGGSAKAAGASSVLSAIEQMFTTSFDTPPRHA-------SLPASSPSNSST 708
            .|.:      .|....||   .|...:|.::|...||:.:.....|       |:.|:...:..|
  Rat   516 DPTIKYQYLREEDLEDGS---KGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGT 577

  Fly   709 KNTSPVASSILKRLGIDETVDYNKPLIDTNDPYYQHYR-------------YTSSERSGSECSAE 760
            |....:.|.||:         ....|.:...|....::             ||..::. :|...|
  Rat   578 KPPMAMGSQILQ---------IRPNLANKLRPIAPKWKGMPLGPVPASLALYTQVKKE-AEDKEE 632

  Fly   761 ARPRLDAPTPEKQQQGGGHDEESSKPAIK---QEREAESKPVKMEIKSEFVDEPNEAEETSKMEA 822
            ...:....:|.::.......|..|...|:   :.|:|||.|:|.|.|. ..::|...|..|
  Rat   633 VMKQCRKESPHEEATSFSQPESESFSKIEPPSESRKAESCPLKEEEKL-LKEKPEPLEPVS---- 692

  Fly   823 AVVNGSATNN------------------NNNIVERSSPKTPSSAASPQTRLLP---------PRS 860
            ::.||.|..|                  ||::.:.:.|....|.:||.:..:|         ...
  Rat   693 SLTNGCAVANHSPALPSINPLSALQSVLNNHLGKATEPLRSPSCSSPNSSTIPMFHKSSLGVVDK 757

  Fly   861 PAESQRSVTPKSPASSHKSYDGSSEGTKKFPSDSLNALSSMFDSLGS 907
            |..|..|..|.:..|.|..::.:.:......|.|..|.||...|..|
  Rat   758 PVISPTSTRPAASVSRHYLFENTDQPIDLTKSKSKRAESSQAQSCTS 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tsh	NP_523615.2	zf-C2H2_2	<354..>382	CDD:463690	11/27 (41%)
		C2H2 Zn finger	356..378	CDD:275371	8/21 (38%)
		C2H2 Zn finger	468..490	CDD:275371	11/21 (52%)
		C2H2 Zn finger	535..557	CDD:275371	6/21 (29%)
		PTZ00449	<751..>893	CDD:185628	34/171 (20%)
Tshz2	XP_038962660.1	C2H2 Zn finger	241..263	CDD:275371	8/21 (38%)
		C2H2 Zn finger	301..323	CDD:275371	11/21 (52%)
		homeodomain	861..929	CDD:238039