DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tsh and Tshz2

DIOPT Version :9

Sequence 1:	NP_523615.2	Gene:	tsh / 35430	FlyBaseID:	FBgn0003866	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_038962660.1	Gene:	Tshz2 / 100911757	RGDID:	6490867	Length:	1053	Species:	Rattus norvegicus

Alignment Length:	892	Identity:	186/892 - (20%)
Similarity:	308/892 - (34%)	Gaps:	258/892 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 LDFRTNLYGRAE--SAEPPASEGEEEEFDDGANNPLDLSVGTRKRGHESEPQLGHIQVKKMFKSD 218
            |:.|...|.:.|  ..|....|.|||:.|.|:   :....|:...|.:.|.:.|..| |..|...
  Rat    31 LELRRGGYAQEEVLKEEEEIKEEEEEDEDSGS---VAQHQGSNDTGTDEELETGPEQ-KGYFSCQ 91

  Fly   219 SPPANSVASPSA--SQLLPGVNPYLAAVAAANIFRAGQFPD--WNSKNDLVVDP---LEKMSDIV 276
            :.|.:.:::..|  ..||...:..::.:.:.   .:...||  .|....|..:|   ::||:.:.
  Rat    92 NSPGSHLSNQDAENESLLSDASDQVSDIKSV---CSRDAPDKKANPHAKLPSEPHNCMDKMTAVY 153

  Fly   277 KGGA-----SGMGTKEKMHSSK---ATTPQAASQP---------PKSPVQPTPNQNSESGGGSGG 324
            ....     ||:|...|:.:|:   ..|...:|:.         .||..|..|
  Rat   154 ANILSDSYWSGLGLGFKLSNSERRNCDTRNGSSKNDFDWHQDALSKSLQQNLP------------ 206

  Fly   325 GAAGSGAVTK-ARHNIWQSHWQNKGVASSV------FRCVWCKQSFPTLEALTTHMKDSKHCGVN 382
                |.:|:| :..:..|.:.||..:..||      |||..|..::.||..||.||.::.|.
  Rat   207 ----SRSVSKPSLFSSVQLYRQNSKMCGSVFTGASRFRCRQCSAAYDTLVELTVHMNETGHY--- 264

  Fly   383 VPPFGNLPSNNPQPQHHHPTPPPPPQNHNLRKHSSGSASNHSPSANVKNAFQYRGDPPTPLPRKL 447
                                     |:.|.:|......|...|.   |.|||
  Rat   265 -------------------------QDDNRKKDKLRPTSYSKPR---KRAFQ------------- 288

  Fly   448 VRGQNVWLGKGVEQAMQILKCMRCGESFRSLGEMTKHMQETQHYTNILSQEQSISIKSG------ 506
                    ....:.|.::||||.||:||.||.:::.||.:|:||..:..:|...:|.|.
  Rat   289 --------DMDKDDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVAPAK 345

  Fly   507 ------NANANSDAKESH--NSLSSEESRTL------------------------SAVLTCKVCD 539
                  |...:.|:....  :|.||::|..|                        |.:|.|..|.
  Rat   346 KRVFDVNRPCSPDSTTGSLADSFSSQKSANLQLPSNSRYGYQNGASYTWQFEACKSQILKCMECG 410

  Fly   540 KAFNSLGDLSNHMAKNNHYAEPLLQSAGARK------RPAPKKREKSL---PVRKLLEMKGGSGT 595
            .:.::|..|:.||....|:.:  :.|:.::|      .|...::.:||   |..:.|..|..|.:
  Rat   411 SSHDTLQQLTTHMMVTGHFLK--VTSSASKKGKQLVLDPLAVEKMQSLSESPNSESLAPKPSSNS 473

  Fly   596 TQEDHSN----EKTSVQGKPGLGPGGGDKNDAALFAERMRQYITGVKAPEEIAKVAAAQLLAKNK 656
            ..|..::    :|.|.:.|       |:.|:..          .|||..|      ....|.|..
  Rat   474 PSESTASATELKKESKKEK-------GEINEDE----------QGVKNEE------YEDALQKPL 515

  Fly   657 SPEL------VEQKNGGSAKAAGASSVLSAIEQMFTTSFDTPPRHA-------SLPASSPSNSST 708
            .|.:      .|....||   .|...:|.::|...||:.:.....|       |:.|:...:..|
  Rat   516 DPTIKYQYLREEDLEDGS---KGGGDILKSLENTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGT 577

  Fly   709 KNTSPVASSILKRLGIDETVDYNKPLIDTNDPYYQHYR-------------YTSSERSGSECSAE 760
            |....:.|.||:         ....|.:...|....::             ||..::. :|...|
  Rat   578 KPPMAMGSQILQ---------IRPNLANKLRPIAPKWKGMPLGPVPASLALYTQVKKE-AEDKEE 632

  Fly   761 ARPRLDAPTPEKQQQGGGHDEESSKPAIK---QEREAESKPVKMEIKSEFVDEPNEAEETSKMEA 822
            ...:....:|.::.......|..|...|:   :.|:|||.|:|.|.|. ..::|...|..|
  Rat   633 VMKQCRKESPHEEATSFSQPESESFSKIEPPSESRKAESCPLKEEEKL-LKEKPEPLEPVS---- 692

  Fly   823 AVVNGSATNN------------------NNNIVERSSPKTPSSAASPQTRLLP---------PRS 860
            ::.||.|..|                  ||::.:.:.|....|.:||.:..:|         ...
  Rat   693 SLTNGCAVANHSPALPSINPLSALQSVLNNHLGKATEPLRSPSCSSPNSSTIPMFHKSSLGVVDK 757

  Fly   861 PAESQRSVTPKSPASSHKSYDGSSEGTKKFPSDSLNALSSMFDSLGS 907
            |..|..|..|.:..|.|..::.:.:......|.|..|.||...|..|
  Rat   758 PVISPTSTRPAASVSRHYLFENTDQPIDLTKSKSKRAESSQAQSCTS 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tsh	NP_523615.2	zf-C2H2_2	<354..>382	CDD:289522	11/27 (41%)
		C2H2 Zn finger	356..378	CDD:275371	8/21 (38%)
		C2H2 Zn finger	468..490	CDD:275371	11/21 (52%)
		C2H2 Zn finger	535..557	CDD:275371	6/21 (29%)
Tshz2	XP_038962660.1	C2H2 Zn finger	241..263	CDD:275371	8/21 (38%)
		C2H2 Zn finger	301..323	CDD:275371	11/21 (52%)
		homeodomain	861..929	CDD:238039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5308
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8976
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12487
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.150