DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11630 and F10C2.3

DIOPT Version :9

Sequence 1:	NP_610124.1	Gene:	CG11630 / 35429	FlyBaseID:	FBgn0032964	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_506015.2	Gene:	F10C2.3 / 179650	WormBaseID:	WBGene00008644	Length:	604	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	145/540 - (26%)
Similarity:	249/540 - (46%)	Gaps:	75/540 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 KCMYYAMERHTDFDNRYLYSREFELLTDGNNTIEPHADIIRAEC---FINATSIYNGVHFYVHPT 173
            :|.|...::....|.:..||.....    |.:::..::.:...|   :...|.:|:..|..:.|
Worm   111 ECQYRTYDKMDGDDEQLNYSEWISF----NMSVKIESEFVEVSCQRAWFPRTKVYSNNHNQIIP- 170

  Fly   174 DEWLRTAQGLPPLKLASDVGSLSVLIVGLDSISQMHFHRSMARTANFLLSL-PHVELKGFNRLGE 237
                 .::..|    .||  ..||:::.|||:|..:|.|:|.:|.:.:.|| ......|..::|:
Worm   171 -----ISRSQP----VSD--KSSVIVIVLDSVSHSNFRRTMNKTLDVMHSLYGSFIFDGMTKIGD 224

  Fly   238 DGFDSLMPLLSG-LSGQELKDVSSNLSSLDSCPFIWKVFQKAGYETGLGEDNIDKSLF---VKGF 298
            :.|.:.:...:| ....|..|........|   .|||.:::.||.|...||....:||   .|||
Worm   225 NSFSNAVGFFAGKWWNTEFGDAHGYFDDHD---LIWKHYRENGYRTLYAEDYPGFNLFNYLSKGF 286

  Fly   299 RKPPTDFYLRPALLEM---WLKTRTDGL-FGTH--CNEKDNYAMVLREFLFKMLPHHTSHRFFTF 357
            :|.|.|.|.||..|.:   ::..|:..| :|.|  .|.:.||   |.:|:.|    :.....|..
Worm   287 KKKPVDHYFRPYWLNVYWTYVHRRSRNLCYGNHRMHNLQLNY---LSQFVSK----YKDQPKFAI 344

  Fly   358 LWWTQ-GIDHL--FNYGRKLDQPFLKMFKAIGRSGLLKNTVLLVVSNHGLNKGRFYKTVQGKVEE 419
            .|.|: |.|.|  ..||.:....|||  |.:..   |:|:.|.::|:||.......||..|::||
Worm   345 SWLTELGHDWLNQVRYGDEDLANFLK--KHVED---LENSYLFIMSDHGHRFDNIRKTSIGRLEE 404

  Fly   420 SQPLAILCYPRWLEERYPQAIGNLKSNNRRLVTAFDLHATLQNLPNLTSLEDEQLQQRRVDLWAM 484
            ..|...:..|:.| .:..:.:..::.|:::|.:.||::||.:::.|    ..:|
Worm   405 RLPFFSVSLPKKL-RKDSKLVDTVRKNSKKLTSFFDVYATFRHILN----NSKQ----------- 453

  Fly   485 GKDIPRGISLFLPIPDHRDCFLAAIPTANCLC--QQPRNVSTSDGYVQRAARLIIRNLNKMIHTH 547
             .|:.||.||||||.| |:|..|.||...|:|  :.|.||| ::..::..|....:::|:.:..|
Worm   454 -PDVMRGESLFLPIKD-RNCETAHIPEEFCVCDTEVPLNVS-ANAQIRTMAEDFAKDINQRLDPH 515

  Fly   548 TPPCKTLYLDRVLTADKWRRIADEHQSEFRVRLIATPGEGQFEGIVRYTGY--KLAVDGHISRVN 610
             |.|..|||..|::..   ::.|..:..:|..:..:|....||.::.|..:  :..|.|.|:|:|
Worm   516 -PQCVQLYLKNVISVS---QVGDVKEQRYRFTIEVSPSNAIFEALLLYDPFESQTTVIGDINRIN 576

  Fly   611 DYRNGSQCIRNYLIEMYCFC 630
            .|.|.|.|:::..:...|||
Worm   577 KYGNQSLCVQDQFLRKLCFC 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11630	NP_610124.1	DUF229	66..560	CDD:281053	126/466 (27%)
CG11630	NP_610124.1	ALP_like	195..467	CDD:293745	82/285 (29%)
F10C2.3	NP_506015.2	DUF229	110..527	CDD:281053	126/466 (27%)
F10C2.3	NP_506015.2	ALP_like	182..451	CDD:293745	82/288 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970