DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11630 and Y38A10A.2

DIOPT Version :9

Sequence 1:	NP_610124.1	Gene:	CG11630 / 35429	FlyBaseID:	FBgn0032964	Length:	631	Species:	Drosophila melanogaster
Sequence 2:	NP_504570.2	Gene:	Y38A10A.2 / 178994	WormBaseID:	WBGene00021389	Length:	599	Species:	Caenorhabditis elegans

Alignment Length:	584	Identity:	125/584 - (21%)
Similarity:	219/584 - (37%)	Gaps:	128/584 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IRCCFLYSLIIFSFVYYY-----------------NDVVVDN-----IIFEEHHLVEKYSVDTKG 48
            |:...|.:.::.:.|||:                 .||::.|     |::.|
Worm     2 IQAVLLLASVLGASVYYWQHNKEWSYVQTLDDIDRGDVILPNYNAHPILYNE------------- 53

  Fly    49 CRMLTMVPNEYDVM-FLWRGLRRDFCASNLNLTSFSNCTYNYLRTEVNMELAKARFGVETLESFK 112
            |....:.|.|.|:: ::.:..||..|.|:               .:|.:|...::..: ||:|..
Worm    54 CTWPILDPYEPDILKYIKKRNRRLACRSS---------------PDVEVEWLDSKIQI-TLKSAN 102

  Fly   113 CMYYAMERHTDFD-NRYLY-SREFELLTDGNNTIEPHADIIRAECFINATSIYNGVHFYVHPTDE 175
            .|.......:.|. |..:: |...:|..|....| |:.: ...||..|...||. ..||.:..|
Worm   103 VMSCVASDLSGFSANEDVFVSPAIKLEADFPLEI-PYTN-FAVECEQNGKRIYR-KSFYNYKKD- 163

  Fly   176 WLRTAQGLPPLK-LASDVGSLSVLIVGLDSISQMHFHRSMARTANFLLSLPHVELKGFNRLGEDG 239
                 |...|:: :.|...|.|:.::.|.|:|.....|...:|..........:...||::.
Worm   164 -----QAEKPVEAMESTPTSPSIAVLYLRSMSHSQLQREFPKTVKASRKFGFYDFAMFNKIS--- 220

  Fly   240 FDSLMPLLSGLSGQELKDVSSNLSSLDSCPFIWKVFQKAGYETGLGEDNIDKSLFVKGFRKPPTD 304
             |::..:::|....  |||...:..........|||..... :|:                 |:|
Worm   221 -DNITDIVNGTFWH--KDVRHTVGEYMKNERFCKVFSNTNL-SGV-----------------PSD 264

  Fly   305 FYLRPALLEMWLKTRTDGLFGTHCNEKDNYAMVLREFLFKMLPHHTSHRFFTFLWWTQGIDHLFN 369
            :.     :..|    ...|....|::.|:.:..|.|...:...|:|.|.:.:.::....|
Worm   265 YD-----ISNW----AHSLKSDSCSDDDSVSERLIEQWAQFSIHNTDHCYLSHIFVNNTI----- 315

  Fly   370 YGRKLDQPFLKMFKAIGRSGLLKNTVLLVVSNHGLNKGRFYKTVQGKVEESQPLAILCYPRWLEE 434
            :.:.||.....:......:.:.|||:::|||..|:..|.|..:..|||||..|:.:...|..:::
Worm   316 WSKSLDDTLSSVMNQFQLNEVFKNTLVVVVSAEGIPVGTFGNSYTGKVEERNPILLAHIPDKVKK 380

  Fly   435 RYPQAIGNLKSNNRRLVT---AFDLHATLQNLPN---LTSLEDEQLQQRRVDLWAMGKDIPRGIS 493
            .|...:.:|:||..||:|   .|||..:...|..   :..:.|:.:..:|..:        ||||
Worm   381 LYSDHVFHLESNQNRLITHLEVFDLLTSFSRLSKNQVIVPVLDDFMDWKRKHV--------RGIS 437

  Fly   494 LFLP-IPDHRDCFLAAIPTANCLCQQPRNVSTSDGYVQR---AARL-------IIRNLNKMIHT 546
            .:.. ||.:|.|:...|....|||.. |.:.....|.|.   |.||       |:.|.:.|..|
Worm   438 PWQTLIPRNRTCYHVPIADEFCLCMD-RKMDIEREYNQTFAIAQRLYDKMESDILSNYSCMHET 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11630	NP_610124.1	DUF229	66..560	CDD:281053	111/501 (22%)
CG11630	NP_610124.1	ALP_like	195..467	CDD:293745	58/277 (21%)
Y38A10A.2	NP_504570.2	DUF229	72..465	CDD:281053	101/464 (22%)
Y38A10A.2	NP_504570.2	ALP_like	179..405	CDD:304875	55/263 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.970