DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31612 and ZNF14

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_066358.2	Gene:	ZNF14 / 7561	HGNCID:	12924	Length:	642	Species:	Homo sapiens

Alignment Length:	730	Identity:	165/730 - (22%)
Similarity:	255/730 - (34%)	Gaps:	196/730 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 NLDLTKLDQPGAS-YWCNICCRRLKSRLYYNQHLRSGYHIKRAEAECELEQATLGRELTLSKDFS 333
            |:::.|....||. :.|:.|.|........|:|:||  |..:...|.:..:....:...:.|.||
Human    89 NVNINKETFTGAKPHECSFCGRDFIHHSSLNRHMRS--HTGQKPNEYQEYEKQPCKCKAVGKTFS 151

  Fly   334 IKDDADKNE-----PKPPKRQRRANLLRCDLCRHTMARHLIGKHLISHYHFRRLQQQSRIRRQAC 393
            ......|:|     .||         ..|..|         ||..|.:..|:|.::
Human   152 YHHCFRKHERTHTGVKP---------YECKQC---------GKAFIYYQPFQRHER--------- 189

  Fly   394 LQEILKHMGSIVRQSPFQCMPCRFYANTEETFLYHWKSHEHLELTKRLGGTFWCSFCQFNSNTNN 458
                 .|.|    |.|::|..|      .:||:|:....:|....|:   .:.|..|      ..
Human   190 -----THAG----QKPYECKQC------GKTFIYYQSFQKHAHTGKK---PYECKQC------GK 230

  Fly   459 SMLLHLLDSSHKEVLLALNRSVPICIAQRRRIQCSRCGMEFLYNIQLRQHSITEHPGLALTGTAA 523
            :.:.:.....||.....           .:..:|.:||..|......|.|..| |.|
Human   231 AFICYQSFQRHKRTHTG-----------EKPYECKQCGKAFSCPTYFRTHERT-HTG-------- 275

  Fly   524 DEYQSRFRCNLCGSSQKSRLALQRHKKHKHHLARYFCAICRLEFDNSLDARRHRSLVIHKQKARP 588
               :..::|..||.:.....:.:|||:.......|.|..|...|..|...|.|  ::|| ..|||
Human   276 ---EKPYKCKECGKAFSFLSSFRRHKRTHSGEKPYECKECGKAFFYSASFRAH--VIIH-TGARP 334

  Fly   589 QTSIPQPENEIEHMLREVLEETVPSPPAKRSADVNAKCSNSRKTIESSQRLAQHQAEVHSSDNHL 653
            .                                   ||....|...||.....|:........:.
Human   335 Y-----------------------------------KCKECGKAFNSSNSCRVHERTHIGEKPYE 364

  Fly   654 CLSCGISFESAQALGRHTRSCQPLASTSTPADLSQAQKKSMYSCDQCRFQSQYESDLVYHRIFHT 718
            |..||.||..:.:|..|.|       |.|        .:..|.|.||.....:.|.|..|...||
Human   365 CKRCGKSFSWSISLRLHER-------THT--------GEKPYECKQCHKTFSFSSSLREHETTHT 414

  Fly   719 RSGTIGKNEVLQCPLCPKNFK-KHSLRAHLRNHTNEKIFECTECLQKFARRHNLKNHVITKHAKV 782
                  ..:..:|..|.|.|. ..||:.|.|.|..||.:||.:|.:.|......:.|   :.:..
Human   415 ------GEKPYECKQCGKTFSFSSSLQRHERTHNAEKPYECKQCGKAFRCSSYFRIH---ERSHT 470

  Fly   783 GDKEKKKYAAKDVEQSKPKYQCGTCGKLLAKKYSLKLHEISHSKAVERNYLCHFADCSYAGRT-- 845
            |:|               .|:|..|||:..:..|.:|||.:|:.  |:.|     :|...|:|
Human   471 GEK---------------PYECKQCGKVFIRSSSFRLHERTHTG--EKPY-----ECKLCGKTFS 513

  Fly   846 -PESLKTHLVSHS-QENHKCARINCSYVGKSELHLKRHLKSAHSTEKNGEEWFSCDQCDFRARIK 908
             ..||:.|...|: .:..:|.:...:::..|::.|       |.....||:.:.|.||.......
Human   514 FSSSLREHEKIHTGNKPFECKQCGKAFLRSSQIRL-------HERTHTGEKPYQCKQCGKAFISS 571

  Fly   909 GHLRRHSLRHSGQKPHQCPHCD----FQCSTIDNLRKHIIKTGKHPGMFIYHCAKCSDEEAGEIF 969
            ...|.|...|:|:||::|..|.    |..|...:.|.|   ||:.|    |.|.:|     |:.|
Human   572 SKFRMHERTHTGEKPYRCKQCGKAFRFSSSVRIHERSH---TGEKP----YECKQC-----GKAF 624

  Fly   970 KSNSYKEYQHHLKTH 984
            .|:|:  ::.|.:||
Human   625 ISSSH--FRLHERTH 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	6/19 (32%)
		C2H2 Zn finger	731..750	CDD:275368	8/19 (42%)
		C2H2 Zn finger	758..779	CDD:275368	4/20 (20%)
		C2H2 Zn finger	804..824	CDD:275368	8/19 (42%)
		C2H2 Zn finger	834..856	CDD:275368	6/24 (25%)
		C2H2 Zn finger	898..918	CDD:275368	5/19 (26%)
		zf-H2C2_2	910..935	CDD:290200	9/28 (32%)
		C2H2 Zn finger	926..945	CDD:275368	6/22 (27%)
		C2H2 Zn finger	957..984	CDD:275368	7/26 (27%)
ZNF14	NP_066358.2	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	80..97	CDD:275368	2/7 (29%)
		C2H2 Zn finger	105..125	CDD:275368	7/21 (33%)
		C2H2 Zn finger	143..163	CDD:275368	5/19 (26%)
		C2H2 Zn finger	171..191	CDD:275368	7/42 (17%)
		C2H2 Zn finger	199..217	CDD:275368	6/23 (26%)
		C2H2 Zn finger	225..245	CDD:275368	4/25 (16%)
		zf-H2C2_2	237..262	CDD:290200	6/35 (17%)
		COG5048	249..633	CDD:227381	120/500 (24%)
		C2H2 Zn finger	253..273	CDD:275368	7/20 (35%)
		zf-H2C2_2	265..289	CDD:290200	8/35 (23%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	293..316	CDD:290200	6/22 (27%)
		C2H2 Zn finger	309..329	CDD:275368	6/21 (29%)
		C2H2 Zn finger	337..357	CDD:275368	5/19 (26%)
		C2H2 Zn finger	365..385	CDD:275368	8/26 (31%)
		zf-H2C2_2	377..401	CDD:290200	9/38 (24%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		zf-H2C2_2	405..429	CDD:290200	7/29 (24%)
		C2H2 Zn finger	421..441	CDD:275368	8/19 (42%)
		C2H2 Zn finger	449..469	CDD:275368	4/22 (18%)
		zf-H2C2_2	461..486	CDD:290200	8/42 (19%)
		C2H2 Zn finger	477..497	CDD:275368	8/19 (42%)
		C2H2 Zn finger	505..525	CDD:275368	6/19 (32%)
		zf-H2C2_2	517..542	CDD:290200	5/24 (21%)
		C2H2 Zn finger	533..553	CDD:275368	4/26 (15%)
		C2H2 Zn finger	561..581	CDD:275368	5/19 (26%)
		zf-H2C2_2	574..596	CDD:290200	8/21 (38%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		zf-H2C2_2	601..626	CDD:290200	11/36 (31%)
		C2H2 Zn finger	617..637	CDD:275368	7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000