DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and Zfp788

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_001347603.1	Gene:	Zfp788 / 67607	MGIID:	1914857	Length:	884	Species:	Mus musculus

Alignment Length:	905	Identity:	208/905 - (22%)
Similarity:	324/905 - (35%)	Gaps:	255/905 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 GGKWKPEQ--------RPQLRHPHIERLSPSWD-EPPEENYTHPPADHTKGKWVPGSKQLEYREN 270
            |.||:.:.        |...|....|||..|.: :...|.:|..|   |.....||.|
Mouse    64 GNKWEDQSMEDEHTNPRRSQRICKFERLYESTEGDQSGEIFTKTP---TLTNIFPGLK------- 118

  Fly   271 LDLTKLDQPGA-SYWCN--------------ICCRRLKSRLYYNQHLRS-------GYHIKRAEA 313
               ::||:.|. .|.|.              |..:.|.....||....|       |.:.:....
Mouse   119 ---SELDESGGMQYKCEQTWKTDLNSVTSIPIYTQNLSMSRSYNVCATSFGFPSSFGRYQETPVG 180

  Fly   314 ECELEQATLGRELTLSKDFSI---KDDAD-KNEPKPPKR--------------QRRANLLRCDLC 360
            |...||..  :....:|.|.|   .|:|| .||.||..|              ..|.....|.||
Mouse   181 EQHCEQKV--KNCPSAKSFYIHEMNDNADIDNEHKPFGRAPSSFGSCESRGRINTRKKPYECRLC 243

  Fly   361 -RHTMARHLIGKHLISHYH------------FRRLQ--QQSRIRR-----------------QAC 393
             :..|...|:.||.|:|.:            ||...  |:.:|..                 |..
Mouse   244 SKSFMYPSLLQKHEITHSNEKPYGCLQCGKAFRNFSSLQKHKIAHTEEKPYKCHYCNKVFICQGS 308

  Fly   394 LQEILK-HMGSIVRQSPFQCMPCRFYANTEETFLYHWKSH--EHLELTKRLGGTF---------- 445
            ||..:: |.|    :.|::|..|........:|..|.|.|  |.....|:.|.:|
Mouse   309 LQSHIRVHTG----EKPYECKQCGKAFRVNSSFWRHKKVHTGEKPYECKQCGKSFIYPSLLQTHE 369

  Fly   446 ---------WCSFCQFNSNTNNSMLLHLLDSSHKEVLLALNRSVPICIAQRRRIQCSRCGMEFLY 501
                     .|..|.....:::|:.:|  :.:|               ..::..:|.:||..|:|
Mouse   370 RTHSAEKPYSCKQCGKAFKSHSSLRVH--ERNH---------------TGKKPYECKQCGRSFIY 417

  Fly   502 NIQLRQHSITEHPGL---------------------ALTGTAADEYQSRFRCNLCGSSQKSRLAL 545
            ...|:.|..| |.|:                     ..|.|....|:    |..|..|..:|..|
Mouse   418 PCLLQIHERT-HSGVKPYGCKQCGKAFRRLSDLRVHERTHTGEKPYE----CKQCAKSFINRYLL 477

  Fly   546 QRHKKHKHHLARYFCAICRLEFDNSLDARRHRSLV-IHKQKARPQTSIPQPENEIEHMLREVLE- 608
            :.|:|.......|.|.||...|       .:.||: :|::....:...|..:.:...:...:|:
Mouse   478 KMHQKSHTGEKPYKCKICSKAF-------VYPSLLKLHERSHTGEKPYPCKQCDKAFIFPSLLKL 535

  Fly   609 ----ETVPSPPAKRSADVNAKCSNSRKTIESSQRLAQHQAEVHSSDNHLCLSCGISFESAQALGR 669
                .|...|.|.:      :|..:.|:..|.||..:...:|.:   ::|..|..:|...::|..
Mouse   536 HERTHTGEKPYACK------QCGEAFKSYNSLQRHKRIHTDVKA---YVCKHCSKAFICQRSLQL 591

  Fly   670 HTRSCQPLASTSTPADLSQAQKKSMYSCDQCRFQSQYESDLVYHRIFHTRSGTIGKNEVLQCPLC 734
            |.|       |.|        .:..|.|:||....:|.:.|..|:|.||     ||| :.:|..|
Mouse   592 HNR-------THT--------GEKPYKCEQCGNSFRYHNSLQRHKIIHT-----GKN-LYECKQC 635

  Fly   735 PKNF-KKHSLRAHLRNHTNEKIFECTECLQKFARRHNLKNHVITKHAKVGDKEKKKYAAKDVEQS 798
            .::| ..:.|:.|.|.|:..|.:|||:|.:.:.....|:.|..|..|:
Mouse   636 DRSFIYPYLLQIHDRTHSGGKPYECTQCGKSYIYPSLLRIHERTHSAE----------------- 683

  Fly   799 KPKYQCGTCGKLLAKKYSLKLHEISHSKAVERNYLCHFADCSYAGRT---PESLKTHLVSHS-QE 859
            || |.|..|||......||::||.:|:.  |:.|     :|...||:   |..|:||...|| .:
Mouse   684 KP-YSCKQCGKAFKSHSSLRVHERNHTG--EKPY-----ECKQCGRSFIYPCLLQTHERIHSGVK 740

  Fly   860 NHKCARINCSYVGKSELHLKRHLKSAHSTEKNGEEWFSCDQCDFRARIKGHLRRHSLRHSGQKPH 924
            .::|.:...::.|.|...:.:.|.|       ||:.:.|.||.........||.|...||.:||:
Mouse   741 PYECKQCGKAFRGHSSFRVHKKLHS-------GEKPYECKQCGKCFIYPSLLRMHERTHSSEKPY 798

  Fly   925 QCPHCDFQCSTIDNLRKHIIKTGKHPGMFIYHCAKCSDEEAGEIFKSNSYKEYQHHLKTH 984
            .|..|.....:..:||:|   ...|.....|.|.:|     |:||:  .|..:|:|.:.|
Mouse   799 DCKQCGKAFKSRSSLREH---ERNHIEEKSYQCQQC-----GKIFR--RYSSFQNHKQIH 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	7/19 (37%)
		C2H2 Zn finger	731..750	CDD:275368	6/19 (32%)
		C2H2 Zn finger	758..779	CDD:275368	6/20 (30%)
		C2H2 Zn finger	804..824	CDD:275368	8/19 (42%)
		C2H2 Zn finger	834..856	CDD:275368	7/24 (29%)
		C2H2 Zn finger	898..918	CDD:275368	6/19 (32%)
		zf-H2C2_2	910..935	CDD:290200	9/24 (38%)
		C2H2 Zn finger	926..945	CDD:275368	5/18 (28%)
		C2H2 Zn finger	957..984	CDD:275368	8/26 (31%)
Zfp788	NP_001347603.1	KRAB	23..64	CDD:307490	208/905 (23%)
		C2H2 Zn finger	240..260	CDD:275368	8/19 (42%)
		C2H2 Zn finger	268..288	CDD:275368	4/19 (21%)
		C2H2 Zn finger	296..316	CDD:275368	3/19 (16%)
		zf-H2C2_2	308..332	CDD:316026	7/27 (26%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	336..361	CDD:316026	8/24 (33%)
		C2H2 Zn finger	352..372	CDD:275368	3/19 (16%)
		C2H2 Zn finger	380..400	CDD:275368	4/21 (19%)
		C2H2 Zn finger	408..428	CDD:275368	8/20 (40%)
		C2H2 Zn finger	436..456	CDD:275368	0/19 (0%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		COG5048	488..883	CDD:227381	112/440 (25%)
		C2H2 Zn finger	492..512	CDD:275368	7/26 (27%)
		C2H2 Zn finger	520..540	CDD:275368	1/19 (5%)
		C2H2 Zn finger	548..568	CDD:275368	5/25 (20%)
		C2H2 Zn finger	576..596	CDD:275368	6/26 (23%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	5/19 (26%)
		C2H2 Zn finger	688..708	CDD:275368	8/19 (42%)
		C2H2 Zn finger	716..736	CDD:275368	7/19 (37%)
		C2H2 Zn finger	744..764	CDD:275368	3/19 (16%)
		C2H2 Zn finger	772..792	CDD:275368	6/19 (32%)
		C2H2 Zn finger	800..820	CDD:275368	5/22 (23%)
		C2H2 Zn finger	828..848	CDD:275368	8/26 (31%)
		C2H2 Zn finger	856..876	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000