DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and WIZ

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_001358518.1	Gene:	WIZ / 58525	HGNCID:	30917	Length:	1889	Species:	Homo sapiens

Alignment Length:	837	Identity:	162/837 - (19%)
Similarity:	258/837 - (30%)	Gaps:	279/837 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 WSAP----AGDPLLKAVRENDETVFKPL----------HFDHEYPEASDEEDDEDEHEEFDAEED 195
            |..|    ||:.:|...|..|..:.:.:          .|.|...|....|........||..:|
Human   125 WEHPLVQEAGEGILSERRFEDSVIVRTMKPHAELEGSRRFLHHRGEPRLLEKHAQGRPRFDWLQD 189

  Fly   196 EEE----YDARRH------SPPIVPASHTGGKWKPEQRPQLRHPHIERLSPSWDEPPEENYTHPP 250
            |:|    .||..|      .||:.|                    ..|:....::.|:
Human   190 EDEQGSPQDAGLHLDLPAQPPPLAP--------------------FRRVFVPVEDTPK------- 227

  Fly   251 ADHTKGKWVPGSKQLEYRENL-DLTKLDQPGASYW-----------------CNICCRRLKSRLY 297
               |....|.|.     ||:| ||..|.||  |.|                 ......||:..|
Human   228 ---TLDMAVVGG-----REDLEDLEGLAQP--SEWGLPTSASEVATQTWTVNSEASVERLQPLL- 281

  Fly   298 YNQHLRSGYHIKRAEAECELEQATLGRELTLSKDFSIKDDADKNEP------------------- 343
              ..:|:|.::      |||.:       .:::..:..|:.:..||
Human   282 --PPIRTGPYL------CELLE-------EVAEGVASPDEDEDEEPAVFPCIECSIYFKQKEHLL 331

  Fly   344 -------KPPKRQRRANL--LRCDLCRHTMARHLIGKHLISHYHFRRLQQQSRIRRQACLQEILK 399
                   :.|.::..|:|  |.|..|....|....   |..|   |:|.|.||.:....:|::.:
Human   332 EHMSQHRRAPGQEPPADLAPLACGECGWAFADPTA---LEQH---RQLHQASREKIIEEIQKLKQ 390

  Fly   400 HMGSIVRQSPFQCMPCRFYANTEETFLYHWKSHEHL---ELTKR-LGGTFWCSFCQFNSNTNNSM 460
            ..|...|::..||..|.|..|:...::.|.|.|...   :.||. .||:....    :.:...|.
Human   391 VPGDEGREARLQCPKCVFGTNSSRAYVQHAKLHMREPPGQTTKEPFGGSSGAG----SPSPEASA 451

  Fly   461 LLHLLDSSHKEVLLALNRSVPICIAQRRRIQCSRCGMEFLYNIQLRQH--SITEHPGLALTGTAA 523
            ||      ::....|:..|.           |..||........||:|  .:..||.....|.|.
Human   452 LL------YQPYGAAVGLSA-----------CVFCGFPAPSESLLREHVRLVHAHPHWEEDGEAY 499

  Fly   524 DE--------YQSRFRC------NLCGSSQKSRLALQRHKKHKHHLARYFCAIC----------- 563
            :|        .|....|      :..|.::.|...:.|.....:..:..|...|
Human   500 EEDPASQPGTSQDAHACFPDTAVDYFGKAEPSLAPMWRENPAGYDPSLAFGPGCQQLSIRDFPLS 564

  Fly   564 -------------RLEFDN-------SLDARRHRSLVIHKQ----KARPQTSIPQPENEIEHMLR 604
                         ||.|.:       ||...|::| .:|.|    :.||.:...:.|.|.|.:
Human   565 KPLLHGTGQRPLGRLAFPSTLASTPYSLQLGRNKS-TVHPQGLGERRRPWSEEEEEEEEEEDV-- 626

  Fly   605 EVL--------EETVPSPPAKRSADVNAKCSNSRKTIESSQRLAQHQAEVHSSDNHLCLSCGISF 661
             ||        |..|.||.|..|....|.....:...|:.|                      :.
Human   627 -VLTSEMDFSPENGVFSPLATPSLIPQAALELKQAFREALQ----------------------AV 668

  Fly   662 ESAQALGRHTRSCQP--LASTSTPADLSQAQKKSMYSCDQCRFQSQYESDLVYHRIFHTRSGTIG 724
            |:.|...:..|...|  |.:...|..::.|:.......::......:..|.:.  :.....|.:|
Human   669 EATQGQQQQLRGMVPIVLVAKLGPQVMAAARVPPRLQPEELGLAGAHPLDFLL--LDAPLGGPLG 731

  Fly   725 -------------KNEVLQCPLCPKNFKKHS---LRAHLRNHTNEKIFECTECLQKFARRHNLKN 773
                         |:|..:||.||..|  |:   |..|:|.|.|           :....:|:::
Human   732 LDTLLDGDPAMALKHEERKCPYCPDRF--HNGIGLANHVRGHLN-----------RVGVSYNVRH 783

  Fly   774 HVITKHAKVGD------KEKKKYAAKDVEQSKPKYQCGTCGKLLAKKYSLKLHEISH 824
            .:..:..|..:      |:|||.|..| ..:....:|..||.....:..|..|..:|
Human   784 FISAEEVKAIERRFSFQKKKKKVANFD-PGTFSLMRCDFCGAGFDTRAGLSSHARAH 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	1/19 (5%)
		C2H2 Zn finger	731..750	CDD:275368	9/21 (43%)
		C2H2 Zn finger	758..779	CDD:275368	1/20 (5%)
		C2H2 Zn finger	804..824	CDD:275368	5/19 (26%)
		C2H2 Zn finger	834..856	CDD:275368
		C2H2 Zn finger	898..918	CDD:275368
		zf-H2C2_2	910..935	CDD:290200
		C2H2 Zn finger	926..945	CDD:275368
		C2H2 Zn finger	957..984	CDD:275368
WIZ	NP_001358518.1	C2H2 Zn finger	317..337	CDD:275368	0/19 (0%)
		C2H2 Zn finger	354..374	CDD:275368	6/25 (24%)
		C2H2 Zn finger	403..423	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000