DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and ZNF280C

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_060136.1	Gene:	ZNF280C / 55609	HGNCID:	25955	Length:	737	Species:	Homo sapiens

Alignment Length:	939	Identity:	172/939 - (18%)
Similarity:	264/939 - (28%)	Gaps:	374/939 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 NDETVFKPLHFD---HEYPEASDEEDD--EDEHEEFDAEEDEE-----EYDA----------RRH 204
            :|:..|:|.:..   ..:.|..:||.:  :.:.||...|:|:|     |..:          |.|
Human     2 DDDKPFQPKNISKMAELFMECEEEELEPWQKKVEETQDEDDDELIFVGEISSSKPAISNILNRGH 66

  Fly   205 SPPIVPASHTGGKWKPEQRPQLRHPHIER-LSPSWDEPPEENYTHPPADHTKGKWVPGSKQLEYR 268
            |    .:|..|.|.:|.. |.:  |.|.| .|....:||.......|..|...|....|..:|..
Human    67 S----SSSSKGIKSEPHS-PGI--PEIFRTASQRCRDPPSNPVAASPRFHLVSKSSQSSVTVENA 124

  Fly   269 ENLDLTKLDQPGASYWCNICCRRLKSRL--------YYNQHLRSGYHIKRAEAECELEQATLGRE 325
            ...|.||..|.|:.....:.....:..|        .:.:.:::..::.:..:..::...|..:.
Human   125 SKPDFTKNSQVGSDNSSILLFDSTQESLPPSQDIPAIFREGMKNTSYVLKHPSTSKVNSVTPKKP 189

  Fly   326 LTLSKDFSIKDDADKNEP--------KPPKRQRR----------------ANLLR-CDLCRHTMA 365
            .|       .:|..:..|        .||....:                |:.|| |..|
Human   190 KT-------SEDVPQINPSTSLPLIGSPPVTSSQVMLSKGTNTSSPYDAGADYLRACPKC----- 242

  Fly   366 RHLIGKHLISHYHFRRLQQQSRIRRQACLQEILKHMGSIVRQSPFQCMPCRFYANTEETFLYHWK 430
                      :..|..|.......:..|...|.|.:|.||:..    .||    :.::|
Human   243 ----------NVQFNLLDPLKYHMKHCCPDMITKFLGVIVKSE----RPC----DEDKT------ 283

  Fly   431 SHEHLELTKRLGGTFWCSFCQFNSNTNNSMLLHLLDSSHKEVLLALNRSVPICIAQRRRIQCSRC 495
                                               ||...::::.:|
Human   284 -----------------------------------DSETGKLIMLVN------------------ 295

  Fly   496 GMEFLYNIQLRQHSITEHPGLALTGTAADEYQSRFRCNLCGSSQKSRLALQRHKKHKHHLARYFC 560
              ||.|.   |...:||......|         .|:|..|....|:.:....|.  ||||
Human   296 --EFYYG---RHEGVTEKEPKTYT---------TFKCFSCSKVLKNNIRFMNHM--KHHL----- 339

  Fly   561 AICRLEFDNSLDARRHRSLVIHKQKARPQTSIPQPENEIEHMLREVLEETVPSPPAKRSADVNAK 625
               .||..|:.....|.:                    .:|..|:     .|:|
Human   340 ---ELEKQNNESWENHTT--------------------CQHCYRQ-----YPTP----------- 365

  Fly   626 CSNSRKTIESSQRLAQHQAEVHSSDNH-------LCLSCGISFESAQALGRHTRSCQPLASTSTP 683
                            .|.:.|....|       :|..|.:|||:...|.:|      :..|..|
Human   366 ----------------FQLQCHIESTHTPHEFSTICKICELSFETEHILLQH------MKDTHKP 408

  Fly   684 ADLSQAQKKSMYSCDQCRFQSQYESDLVYH-RIFHTRSGTIGKNEVLQCPLCPKNFKKHS-LRAH 746
            .::.       |.|..|:|:|...||:..| |..|..:    ||  |.||.|.|..|..: ...|
Human   409 GEMP-------YVCQVCQFRSSTFSDVEAHFRAAHENT----KN--LLCPFCLKVSKMATPYMNH 460

  Fly   747 LRNHTNEKIFECTECLQKFARRHNLKNH--------------------VITKHAKVG-------- 783
            ...|..:.:..|.:|..:|........|                    .:|..|.:|
Human   461 YMKHQKKGVHRCPKCRLQFLTSKEKAEHKAQHRTFIKPKELEGLPPGAKVTIRASLGPLQSKLPT 525

  Fly   784 ----------------------------------DKEKKKYA----AKDVEQSKPKYQCGTCGKL 810
                                              .|..|.:|    |..|..|||:   |...|.
Human   526 APFGCAPGTSFLQVTPPTSQNTTARNPRKSNASRSKTSKLHATTSTASKVNTSKPR---GRIAKS 587

  Fly   811 LAK-------------KYSLKLHEISHSKAVERNYLCH-----FAD----------CSYAGRTPE 847
            .||             |.||.|..|...:.:.:...||     ||.          |.|.....:
Human   588 KAKPSYKQKRQRNRKNKMSLALKNIRCRRGIHKCIECHSKIKDFASHFSIYIHCSFCKYNTNCNK 652

  Fly   848 SLKTHLVSHSQENHKCARINCSYVGKSELHLKRHLKSAHSTEKNGEEWFSCDQCDFRARIKGHLR 912
            :...|::| |..||.         ||.....|:|..:.....      ..|.:|||.|...| |.
Human   653 AFVNHMMS-SHSNHP---------GKRFCIFKKHSGTLRGIT------LVCLKCDFLADSSG-LD 700

  Fly   913 RHSLRHSGQKPHQCPHCDFQCSTIDNLRK 941
            |.:...|.:|.|.|.      ..|:|:.|
Human   701 RMAKHLSQRKTHTCQ------VIIENVSK 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	8/20 (40%)
		C2H2 Zn finger	731..750	CDD:275368	6/19 (32%)
		C2H2 Zn finger	758..779	CDD:275368	5/40 (13%)
		C2H2 Zn finger	804..824	CDD:275368	9/32 (28%)
		C2H2 Zn finger	834..856	CDD:275368	7/36 (19%)
		C2H2 Zn finger	898..918	CDD:275368	8/19 (42%)
		zf-H2C2_2	910..935	CDD:290200	6/24 (25%)
		C2H2 Zn finger	926..945	CDD:275368	4/16 (25%)
		C2H2 Zn finger	957..984	CDD:275368
ZNF280C	NP_060136.1	DUF4195	46..227	CDD:316361	32/194 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..137		23/86 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..223		6/53 (11%)
		C2H2 Zn finger	355..376	CDD:275368	6/52 (12%)
		C2H2 Zn finger	385..406	CDD:275368	7/26 (27%)
		C2H2 Zn finger	415..433	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	535..602		12/69 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000