DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and CG7987

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster

Alignment Length:	831	Identity:	167/831 - (20%)
Similarity:	262/831 - (31%)	Gaps:	247/831 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 ERLSPSWDEPPEENYTHPPADHTKGKWVPGSKQLEYRENLDLTKLDQPGASYWCNICCRRLKSRL 296
            |.::..|.:..........|:...|  :..|::|...|..:.|.| :|   |.|:.|.||.:.:.
  Fly    95 EVITDDWVQHQGAERVEIAAEQIAG--ISSSQELLDMEQDEYTAL-RP---YPCDFCSRRFRKKA 153

  Fly   297 YYNQHLRSGYHIKRAEAECELEQATLGRELTLSKDF----SIKDDADKNEPKPPKRQRRANLLRC 357
            ..|.|:.:  |.......|:|..|...|...|...|    ..:|.||          ..|.....
  Fly   154 TLNNHMLA--HQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAAD----------AEAAAAAA 206

  Fly   358 DLCRHTMARHLIGKHLISHYH------FRRLQQQSRIRRQACLQEILKHMGSI---------VRQ 407
            |........|...:.|..||:      |:..|:|...::....|..:...|.|         |.|
  Fly   207 DSSSAIKFEHQTQRQLDDHYYEQEWPLFQHQQEQENAQQNVHQQHQIVEEGGIQLVASYPDTVAQ 271

  Fly   408 ----------------------------------------------------------------- 407

  Fly   272 PAAPSRGRISRLKPKEESSQFIVISDKSVEDSRPYMEPEPAQPVVTTSEFIAVEPPPQPNFPVLD 336

  Fly   408 --SPFQCMPCRFYANTEETFLYHWKSHEHLELTKRLGGTFWCSFCQ----FNSNTNNSMLLHLLD 466
              .||.|..|......|:..:.|.|:|       |:...|.|:.||    .||:.......|..:
  Fly   337 HSKPFVCQQCGLAFAREKALVSHTKNH-------RVDSPFECNQCQEMFWDNSSLQEHQKTHQFE 394

  Fly   467 SSHKEV-LLALNRSVPICIAQRR---RIQCSRCGMEFLYNIQLRQHS--ITEHPGLALTGTAAD- 524
            .|:.|. ..:...|.....|..:   ...|:.||:.|.....||:|:  ..:....|..|:.:|
  Fly   395 ESNSEYDPASAEESGSESEADEQLYGEFYCNECGISFHRQDLLRRHAKMHCKPSDQAAVGSNSDV 459

  Fly   525 ---------EYQSRFRCNLCGSSQKSRLALQRHKKHKHHLARYFCAICRLEFDNSLDARRHRSLV 580
                     :..|...||.||.|..|.|.:..|.:.......:.|.:|.:.|......:||
  Fly   460 TAGGDVELAKDSSGHCCNTCGKSFPSALEMLAHAEIHARFPPFKCVLCGISFYEEQAIKRH---- 520

  Fly   581 IHKQKARPQTSIPQPENEIEHMLREVLEETVPSPPAKRSADVNA-KCSNSRKTIESSQRLAQHQA 644
            :|                                 .:..:::|| .|....|.....:.|.:| |
  Fly   521 LH---------------------------------TRHPSELNANSCVLCGKECRDRKALIKH-A 551

  Fly   645 EVHSSDN-HLCLSCGISFESAQALGRHTRSCQPLASTSTPADLSQAQKKSMYSCDQCRFQSQYES 708
            ..||.:. |.|..||.:|.:...|.||               ::..:.||:. |:.|:.:.....
  Fly   552 WDHSREKCHSCSKCGKNFHNKARLKRH---------------MASHRDKSVV-CEVCQEEFPDGR 600

  Fly   709 DLVYHRIFHTRSGTIGKNEVLQCPLCPKNF-KKHSLRAHLRNHTNEKIFECTECLQKFARRHNLK 772
            .|..||..|:.: |.||  :..|..|.|.| .:.|.:.|:|.||.|:.:.|..|.:.||....|:
  Fly   601 TLSNHRHSHSTT-TPGK--LFPCLECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLR 662

  Fly   773 NHVITKHAKVGDKEKKKYAAKDVEQSKPKYQCGTCGKLLAKKYSLKLHEISHSKA--VERNYLCH 835
                 ||.::...||             .|.|..|.:...::..|:.|..||...  |.|| ..|
  Fly   663 -----KHERIHTGEK-------------PYACSVCPRAFNQRVVLREHIRSHHSGLDVARN-TYH 708

  Fly   836 FADCSYAGRTPESLKTHLVSHSQENHKCARINCSYVG--------KSELHLKRHLKSAHSTEKNG 892
            ...||....:...|..||:.||..|  .|:......|        |.:.|...|:::|:. ..||
  Fly   709 CTVCSEDLASSNDLIQHLIQHSDSN--TAKQRQPVTGPRKYKRRRKLQPHEIAHMRAANK-HVNG 770

  Fly   893 EEWFSCDQCDFRARIKGHLRRHSLRHSGQKPHQC----PHCDFQCSTIDNL 939
            :|..:..:.|                    ..:|    ..|||....:|::
  Fly   771 DEEEAIGEGD--------------------AEECASDIDFCDFDVENVDDI 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	5/19 (26%)
		C2H2 Zn finger	731..750	CDD:275368	7/19 (37%)
		C2H2 Zn finger	758..779	CDD:275368	5/20 (25%)
		C2H2 Zn finger	804..824	CDD:275368	4/19 (21%)
		C2H2 Zn finger	834..856	CDD:275368	6/21 (29%)
		C2H2 Zn finger	898..918	CDD:275368	1/19 (5%)
		zf-H2C2_2	910..935	CDD:290200	4/28 (14%)
		C2H2 Zn finger	926..945	CDD:275368	5/18 (28%)
		C2H2 Zn finger	957..984	CDD:275368
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368	6/21 (29%)
		C2H2 Zn finger	170..186	CDD:275368	5/15 (33%)
		COG5048	326..734	CDD:227381	111/492 (23%)
		C2H2 Zn finger	343..363	CDD:275368	5/19 (26%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	476..496	CDD:275368	8/19 (42%)
		C2H2 Zn finger	504..523	CDD:275368	6/55 (11%)
		C2H2 Zn finger	534..554	CDD:275370	5/20 (25%)
		C2H2 Zn finger	562..582	CDD:275370	7/34 (21%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		C2H2 Zn finger	620..640	CDD:275368	7/19 (37%)
		C2H2 Zn finger	648..668	CDD:275368	7/24 (29%)
		zf-H2C2_2	661..685	CDD:290200	8/41 (20%)
		C2H2 Zn finger	676..696	CDD:275368	4/19 (21%)
		C2H2 Zn finger	709..726	CDD:275371	3/16 (19%)
		Hph	921..>1017	CDD:290417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100