DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and CG10543

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_001369100.1	Gene:	CG10543 / 37379	FlyBaseID:	FBgn0034570	Length:	1666	Species:	Drosophila melanogaster

Alignment Length:	1085	Identity:	222/1085 - (20%)
Similarity:	358/1085 - (32%)	Gaps:	313/1085 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SATLISSSNLDHSYDGFHF-------TEPEAPSSYLRK-----TAASHGGKTSKSLTEAYDLPYE 110
            |..|:.|.|.....|...|       ..||:....:|.     .||:..|::.....:     :|
  Fly    17 SLNLLDSLNTALRCDAIQFLLQTLKCKYPESCDQVVRNLFSHIAAANDNGESGGRAQQ-----HE 76

  Fly   111 LGADLFFSSLQLQSVATGGKIGSVPRQERSKDESWSAPAGDPLLKAVRENDETVFKPLHFDHEYP 175
            |.     .:.|||.:.|..|        ..|:......|     :..|||||
  Fly    77 LA-----RTKQLQLLLTAKK--------EKKELGIGCEA-----EIKRENDE------------- 110

  Fly   176 EASDEEDDEDEHEEFD----------AEEDEEEY--DARRHSPPIVPASHTGGKWKPEQRPQLRH 228
               :|....|.::.|:          .||:||::  ||...:...: ..|||.
  Fly   111 ---EEAGSTDLNQNFEKIPCKEEFLCLEEEEEDFLDDADTQNSSSL-QFHTGN------------ 159

  Fly   229 PHIERLSPSWDEPPE-----------ENYTHPPADHTKGKWVPGSKQLEYRENLDLTKLDQPGAS 282
             :::.|:....:|.|           ..|.....|...|   .|... |...|....|:
  Fly   160 -NVDALALGPGDPLELIQSGVSLLVKRKYAATFDDELIG---DGDGD-EANSNSSDGKM------ 213

  Fly   283 YWCNICCRRLKSRLYYNQHLRSGYHIKRAEAECELEQATLGRELTLSKD--FSIKDDADKNE--P 343
                     :|.:...|.||... .::|.|     |...||......:|  ::::......|  .
  Fly   214 ---------VKRKRTNNMHLTVS-SVRRKE-----EHGQLGDGYVFHEDSQYTMRYHHSTGEFSE 263

  Fly   344 KPPKRQRRANLLRCDLCRH------------TMARHLIG----KHLISHYHFRRLQQ--QSRIRR 390
            :..|.|.|| |||..|.:|            .:...|:|    ..::.....:||::  :.|.||
  Fly   264 RAFKAQFRA-LLRLALSQHHKPFLRQFYENFVVNGRLLGTTPSMRVLKELREQRLEEWRRQRERR 327

  Fly   391 QACLQEILKHMGSIVRQSPFQCMPCRFYANTEETFLYHWK--------SHEHLELTKRLGGTFWC 447
            |..   ||.......|...|| .......|.||......:        ..:|||..:|.......
  Fly   328 QLV---ILMEQSETQRDEEFQ-QQQELVENQEEVQQEQEQQQQQLEDIQQQHLEEIQRQQQLPAI 388

  Fly   448 SF--CQFNSNTNNSMLLHLLDSSHKEVLLALNRSVPICIAQRRRIQCSRCGMEFLYNIQLRQHSI 510
            ||  .:..|.|.:.:      ||..:.::.....:...:...|.|.    |:|.       :..|
  Fly   389 SFGDSELESETESQL------SSAAQEIMKFEEFIDEGVGAGRLID----GLEM-------EPEI 436

  Fly   511 TEHPGLALTGTAADEYQSRFRCNLCGSSQK----SRLALQRHKKHKHHLARYFCA---ICRLEFD 568
            .:....|.:..:|..:.|....:..||:..    |.:.|:.:..|.|||:....|   |..|...
  Fly   437 DDMLAGAGSMNSASGHSSNSSSSGSGSAGNGNGISGVILENNSHHTHHLSSSSSANLVINGLTSS 501

  Fly   569 NSLDARRHRS--LVIHKQKARPQTSIPQPENEIEHMLREVLEETVPSPPAKRSADV--------- 622
            ||:....:.|  :.:|    |||.: ||.:|::...::.  .:.:|......:.|:
  Fly   502 NSISNNNNNSNNVSLH----RPQLT-PQAQNQLAASMKP--SDHIPISMPMENMDLKAGQAAHGT 559

  Fly   623 -NAKCSNSRKTIESSQRLAQHQAEVHSSDNHLCLSCGISFESAQ---ALGRH------------- 670
             ||.......::.|  :|.|.|...:||:|.|.:..|:..:..|   |:..|
  Fly   560 ANAIMQGGSSSLAS--QLHQQQKPYNSSNNPLSMMGGMMQQQQQQHVAMPHHQRQMMMMPEDFPQ 622

  Fly   671 -------TRSCQPLASTS----TPADLSQAQKKSMYSCDQCRFQSQYESDLVYHRIFHTRS---- 720
                   :|....||:.|    |||  ...|..|....|.....:..:.|.:.|.:....:
  Fly   623 HGASMMNSRQMPALAALSNLGDTPA--MSGQLNSSLELDDNDLSADEDDDDLDHDLDELDAAKQQ 685

  Fly   721 ---GTIGKNEVLQCP----------------------------LCPKNFKKH-SLRAHLRNHTNE 753
               |....:..||.|                            ||||:::|. ||..|.:.|..
  Fly   686 LIDGGSSSSTSLQAPPSQHGSGSGGSGGQTPGSKKDKPSYNCLLCPKSYRKRKSLLDHYKMHPG- 749

  Fly   754 KIFECTECLQKFARRHNLKNHVI----TKHAKVGDKEKKKYAAKDVEQSKPKYQCGTCGKLLAKK 814
               .|.:|.|   |..|....:|    |.|.|                 :..:.|.|||:..::|
  Fly   750 ---YCHDCGQ---RNGNTLEEIIHHNRTMHVK-----------------EFPFVCETCGESYSRK 791

  Fly   815 YSLKLHEISHSKAVERNYLCHFADCSYAGRTPESLKTHLVSHSQE-NHKCARINCSYVG---KSE 875
            .....|..||:|...:.:.|  .:|..  :.|:.   .|..|.:| .||.....|...|   :|:
  Fly   792 QQFHAHVESHNKKEIKTFPC--GECGL--KFPQK---KLQQHFEETGHKADGAICEVCGEEFQSK 849

  Fly   876 LHLKRHLKSAHSTEKNGEEWFSCDQCDFRARIKGHLRRHSLRHSG-QKPHQCPHCDFQCSTIDNL 939
            ..|.:|:...|..    :.:|.|..|..|..:|.:|.||...|:. ::|:.|..|.....|...|
  Fly   850 NALYQHIIRVHKR----DNFFECHICHNRFTLKANLERHVQLHTEIKRPYVCDLCGSSYFTYPAL 910

  Fly   940 RKHIIKTGKHPGMFIYHCAKCSDEEAGEIFKSNSYKEYQHHLKTH 984
            ::|.  :..|..:....|..|     |:.|  .|.|..|.||.:|
  Fly   911 KEHY--SNAHVDVSECKCTLC-----GKRF--GSAKSLQRHLPSH 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	3/19 (16%)
		C2H2 Zn finger	731..750	CDD:275368	9/47 (19%)
		C2H2 Zn finger	758..779	CDD:275368	7/24 (29%)
		C2H2 Zn finger	804..824	CDD:275368	6/19 (32%)
		C2H2 Zn finger	834..856	CDD:275368	4/21 (19%)
		C2H2 Zn finger	898..918	CDD:275368	7/19 (37%)
		zf-H2C2_2	910..935	CDD:290200	7/25 (28%)
		C2H2 Zn finger	926..945	CDD:275368	5/18 (28%)
		C2H2 Zn finger	957..984	CDD:275368	9/26 (35%)
CG10543	NP_001369100.1	C2H2 Zn finger	727..747	CDD:275368	8/19 (42%)
		C2H2 Zn finger	751..773	CDD:275368	7/24 (29%)
		C2H2 Zn finger	781..801	CDD:275368	6/19 (32%)
		PHA00733	<804..860	CDD:177301	13/62 (21%)
		C2H2 Zn finger	811..827	CDD:275368	4/22 (18%)
		C2H2 Zn finger	839..860	CDD:275368	5/20 (25%)
		C2H2 Zn finger	868..888	CDD:275368	7/19 (37%)
		C2H2 Zn finger	897..913	CDD:275368	4/15 (27%)
		C2H2 Zn finger	926..946	CDD:275368	9/26 (35%)
		C2H2 Zn finger	954..975	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100