DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and az2

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster

Alignment Length:	737	Identity:	141/737 - (19%)
Similarity:	236/737 - (32%)	Gaps:	255/737 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 SLQLQSVATGGKIGSVPRQERSKDESWSAPAGDPLLKAVREN--DETVFKPLHFDHEYPEASDEE 181
            |:| |.:.|...|.|      :|.|...:||...:::...||  .|.:|.      :.|.:|:.:
  Fly    51 SMQ-QELTTSEVISS------AKCEEEVSPAKVFIVEEPPENCLAEDMFV------DVPPSSEND 102

  Fly   182 DDEDEHEEFDAEEDEEEYDA--------RRHSPPIVPASHTGGKWKP---EQRPQLRHPHIERLS 235
            :.....||.:.|:||.:..:        .|:|....|.:    |:.|   .:.|::.. .||...
  Fly   103 ESTSPVEEEEEEDDEVDSSSMTVDCELGTRNSTHFAPLT----KFNPTFYRRSPRITQ-FIELYK 162

  Fly   236 PS---WDEPPEENYTHPPADHTKGKWVPGSKQLEYRENLDLTKLDQPGASYWCNICCRRLKSRLY 297
            ..   || |.:|:|                :..|.|.|.....|:|             ||:.:
  Fly   163 QQTCLWD-PADESY----------------RDKEKRANAYEELLEQ-------------LKATV- 196

  Fly   298 YNQHLRSGYHIKRAEAECELEQATLGRELTLSKDFSIKDDADKNEPKPPKRQRRANLLRCDLCRH 362
             |.|| :.|.:|:.......:.|::.|:                       ::...|.:..|..|
  Fly   197 -NLHL-TAYKLKKCITSLHAQYASISRQ-----------------------KKTQKLTKVPLYYH 236

  Fly   363 TMARHLIGKHLISHYHFRRLQQQSRIRRQACLQEI----------LKHMGSIVRQSPFQCMPCRF 417
                   ||:             |.:..:..|::.          :|.:.:...|...|.:.  .
  Fly   237 -------GKY-------------SFLAERGSLEDADSDDVDGDGKIKLVFTEENQLTTQFID--L 279

  Fly   418 YANTEETFLYHWKSHEHLELTKRLGGTFWCSFCQFNSNTNNSMLLHLLDSSHKEVLLAL--NRSV 480
            |:...:  ||. .:|:|              ||  |.|...|.|:.:.|....|..|.|  :..|
  Fly   280 YSKFPQ--LYD-PAHKH--------------FC--NLNVRKSSLIEITDLLTSEFSLGLVTHYDV 325

  Fly   481 PICIAQRRRIQCSRCGMEFLYNIQLRQHSITEHPGLALTGT--AADEYQSRFRCNLCGSSQKSRL 543
            ...|...|:....|  ::.|.::|....|:.|...:....:  ....::.:.:|.:|..|..:..
  Fly   326 YDSIQSMRQWYSRR--IKTLTDVQCVGLSLAEKQYIERCNSFMPTKSFRQKLKCEVCEHSFSTDH 388

  Fly   544 ALQRHKKHKHHLAR---YFCAICRLEFDNSLDARRHRSLVIHKQKARPQTSIPQPENEIEHMLRE 605
            |||.|:...|.:..   :.|.:|.|.||.
  Fly   389 ALQAHQFRDHKMGDGGWFRCTLCELNFDR------------------------------------ 417

  Fly   606 VLEETVPSPPAKRSADVNAKCSNSRKTIESSQRLAQHQAEVHSSDNHLCLSCGISFESAQALGRH 670
                               ||           .|.||...||...:.:|..|..||.....|..|
  Fly   418 -------------------KC-----------HLQQHSQRVHMDKSFVCEICSRSFAFGNQLAIH 452

  Fly   671 TRSCQPLASTSTPADLSQAQKKSMYSCDQCRFQSQYESDLVYH-RIFHTRSGTIGKNEVLQCPLC 734
            .|:          .|.....|.  :.|:.|....:.:..:..| ...||      |....:|.:|
  Fly   453 KRT----------HDEKHVAKP--FVCEFCGKCFKQKIQMTTHVTAVHT------KIRAFKCDMC 499

  Fly   735 PKNF-KKHSLRAHLRNHTNEKIFECTECLQKFARRHNLKNHVITKHAKVGDKEKKKYAAKDVEQS 798
            ||:| .|..|:.|::.|.|.:...|..|.:.|...:.|..|   :|.   .|||
  Fly   500 PKDFLTKRDLKDHVKAHLNIRDKVCEVCQKAFTNANALVKH---RHI---HKEK----------- 547

  Fly   799 KPKYQCGTCGKLLAKKYSLKLH 820
              ..||..|....:::.||.:|
  Fly   548 --TLQCSLCTTRFSERVSLGVH 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	3/20 (15%)
		C2H2 Zn finger	731..750	CDD:275368	8/19 (42%)
		C2H2 Zn finger	758..779	CDD:275368	5/20 (25%)
		C2H2 Zn finger	804..824	CDD:275368	5/17 (29%)
		C2H2 Zn finger	834..856	CDD:275368
		C2H2 Zn finger	898..918	CDD:275368
		zf-H2C2_2	910..935	CDD:290200
		C2H2 Zn finger	926..945	CDD:275368
		C2H2 Zn finger	957..984	CDD:275368
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	27/160 (17%)
		GT1	276..>341	CDD:304916	19/87 (22%)
		C2H2 Zn finger	377..398	CDD:275368	7/20 (35%)
		C2H2 Zn finger	408..429	CDD:275368	10/86 (12%)
		C2H2 Zn finger	436..456	CDD:275368	7/29 (24%)
		C2H2 Zn finger	467..488	CDD:275368	3/20 (15%)
		C2H2 Zn finger	496..516	CDD:275368	8/19 (42%)
		C2H2 Zn finger	524..544	CDD:275368	6/25 (24%)
		C2H2 Zn finger	551..572	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100