DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and CG12299

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	128/532 - (24%)
Similarity:	192/532 - (36%)	Gaps:	117/532 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 CSRCGMEFLYNIQLRQHSITEHP--------GLALTGTAADEYQSRFR--CNLC----------- 535
            |..|...|::.:.|.||..|.||        .....|..:::|...|.  |.|.
  Fly    50 CMCCAEFFVHPLALYQHMNTLHPHEPGNGQQEQESPGDESEDYSWIFEPVCELAEDGSDSSDGSA 114

  Fly   536 --GSSQKSRLALQRHKKHKHHLARYFCAICRLEFDNSLDARRHRSLVIHKQKARPQTSIPQPENE 598
              ||...|...                     :.|:..|.....|.......:...:|:|...|.
  Fly   115 SSGSDSSSSSD---------------------DDDDDDDDDSSSSSSSSSNSSSSSSSVPTTSNS 158

  Fly   599 IEHMLRE---VLEETVPSPPAKRSADVNAKCSNSRKTIESSQRLAQHQAEVHSSDNHL----CLS 656
            .....:|   .|...|..|...   :...:.::.|::  :|..:.|....|......|    .:|
  Fly   159 NTQQSQESVQPLHGLVAGPGYN---EFQLQMTDPRES--TSIFMVQPTVSVTPLQQLLPPAPTVS 218

  Fly   657 CGISFESAQALGRHTRSCQPLASTSTPADLSQAQKKSMYSCDQCRFQSQYESDLVYHRIFHTRSG 721
            .|:..:|.....|..|.....|....|| |:..||  .:.|..|........||..|...|.
  Fly   219 PGLGLQSTPIKRRRGRRSNIGAPVMDPA-LNGNQK--CFQCTHCEASFPNAGDLSKHVRSHI--- 277

  Fly   722 TIGKNEVLQCPLCPKNFKKH--SLRAHLRNHTNEKIFECTECLQKFARRHNLKNHVITKHAKVGD 784
               .|:..||.:|.|.| .|  ||..|:|.|:.||.::|..|.:.|.:..:|..|:.:...:
  Fly   278 ---TNKPFQCSICQKTF-THIGSLNTHIRIHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVR--- 335

  Fly   785 KEKKKYAAKDVEQSKPKYQCGTCGKLLAKKYSLKLHEISHSKAVERNYLCHFADCSYAGRTPESL 849
                          || :||..|.|......||.||:.:|....| .::|  .:|....:....|
  Fly   336 --------------KP-HQCVQCDKGFINYSSLLLHQKTHIAPTE-TFIC--PECEREFKAEALL 382

  Fly   850 KTHLVSHSQE-NHKCARINCSYVGKSEL--HLKRHLKSAHSTEKNGEEWFSCDQCDFRARIKGHL 911
            ..|:..|:|| .::||....::...|||  |:|.|:         ||:.|:|..||......|.|
  Fly   383 DEHMRMHTQELVYQCAICREAFRASSELVQHMKNHM---------GEKPFTCSLCDRSFTQSGSL 438

  Fly   912 RRHSLRHSGQKPHQCPHCDFQCST-IDNLRKHI-IKTGKHPGMFIYHCAKCSDEEAGEIFKSNSY 974
            ..|...|:|:||.||..|| :|.| ..:|..|: |..|:.|    |.|..|.        ||.|.
  Fly   439 NIHMRIHTGEKPFQCKLCD-KCFTQASSLSVHMKIHAGEKP----YPCPICG--------KSYSQ 490

  Fly   975 KEY-QHHLKTHK 985
            :.| ..|::.|:
  Fly   491 QAYLNKHIQAHQ 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	5/19 (26%)
		C2H2 Zn finger	731..750	CDD:275368	9/20 (45%)
		C2H2 Zn finger	758..779	CDD:275368	5/20 (25%)
		C2H2 Zn finger	804..824	CDD:275368	7/19 (37%)
		C2H2 Zn finger	834..856	CDD:275368	4/21 (19%)
		C2H2 Zn finger	898..918	CDD:275368	6/19 (32%)
		zf-H2C2_2	910..935	CDD:290200	11/24 (46%)
		C2H2 Zn finger	926..945	CDD:275368	7/20 (35%)
		C2H2 Zn finger	957..984	CDD:275368	7/27 (26%)
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	49/186 (26%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		zf-H2C2_2	268..293	CDD:290200	10/31 (32%)
		C2H2 Zn finger	284..304	CDD:275368	9/20 (45%)
		zf-H2C2_2	296..321	CDD:290200	10/24 (42%)
		zf-C2H2_2	312..>387	CDD:289522	21/95 (22%)
		C2H2 Zn finger	312..332	CDD:275368	5/19 (26%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	4/21 (19%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..434	CDD:290200	11/33 (33%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		zf-H2C2_2	437..462	CDD:290200	11/25 (44%)
		C2H2 Zn finger	453..473	CDD:275368	7/20 (35%)
		zf-H2C2_2	465..490	CDD:290200	10/36 (28%)
		C2H2 Zn finger	481..501	CDD:275368	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100