DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and CG4496

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_001285707.1	Gene:	CG4496 / 34000	FlyBaseID:	FBgn0031894	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	719	Identity:	135/719 - (18%)
Similarity:	226/719 - (31%)	Gaps:	244/719 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 EPPEENYTHPPADHTKGK---WVPGSKQLEYRENLDLTKLDQPGASYWCNICCRRLKSRLYYNQH 301
            :.||||:.  ..|..|.|   |..|.:|.|                       :.|:.:....|.
  Fly    51 QEPEENFI--SIDDVKIKSFLWQIGQQQRE-----------------------KELEIKRIMEQE 90

  Fly   302 LRSGYHIKRAEAECELEQATLGRELTLSKDFSIKDDADKNEPKPPKRQRRANLLRCDLCRHTMAR 366
            .|.....:|.|||...:|..:              :.|:.|.:.|    |..::       :.||
  Fly    91 KREKREKERREAEKRRDQEVI--------------ELDEEEAQSP----RGLII-------SAAR 130

  Fly   367 HLIGKHLISHYHFRRLQQQSRIRRQACLQEILKHMGSIVRQSP-FQCMPCRFYANTEETFLYHWK 430
            .|      :|::                       .||.|.:| .:.:|.|.:....|..|....
  Fly   131 SL------AHWN-----------------------SSIRRVTPDIELIPRRVHRVVAEIELSDSD 166

  Fly   431 SHEHLELTKRLGGTFWCSFCQFN----SNTNNSMLLHLLDSSHKEVLLALNRSVPICIAQRRRI- 490
            ..|..|:.:.:........|..|    ..:.|...|.::..|.:|.....:..:....:..||:
  Fly   167 HDEDSEVDEDVSLPSNAVSCVLNEQRQDGSQNPQELVIIVPSDQEDEQKTDNVIKRKSSGSRRLV 231

  Fly   491 --------------QCSRCGMEFLYNIQLRQHSITEHPGLALTGTAADEYQSRFRCNLCGSSQKS 541
                          :|..||.:...|..||:|.:. |.|           :..|.|:||....:.
  Fly   232 KRRPGANRRGRHMYECPDCGKKVQSNYNLRRHMMI-HTG-----------ERPFPCDLCERRFRE 284

  Fly   542 RLALQRHKKHKHHLARYFCAICRLEFDNSLDARR-----HRSLVIHKQKARPQTSIPQPENEIEH 601
            ...|::|::...|..::.|.||.|......|:.|     .::|::.          ||||
  Fly   285 FSDLKKHRRRHSHDPQFICMICHLGAPLEQDSTRCADCESKNLMVK----------PQPE----- 334

  Fly   602 MLREVLEETVPSPPAKRSADVNAKCSNSRKTIESSQRLAQHQAEVHSSDNHLCLSCGISFESAQA 666
               |:.|:|......:...|.:        .||.:....:.|.:|.:..:.:...........:.
  Fly   335 ---ELGEKTTEEHSDEMEGDDD--------EIEEAALENEKQPQVATQPSLMVTLIPPIQSPPEK 388

  Fly   667 LGRHTRSCQPLASTSTPADLSQAQKKSMYSCDQCRFQSQYESDLVYHRIFHTRSGTIGKNEVLQC 731
            :..||:..:|    ..|...|.|...|..|.|         .::....:..||..       ..|
  Fly   389 VPSHTQPSRP----PLPRSCSSANSSSSLSND---------GNIAGKSMSRTRRS-------YPC 433

  Fly   732 PLCPKNF-KKHSLRAHLRNHTNEKIFECTECLQKFARRHNLKNHVITKHAKVGDKEKKKYAAKDV 795
            |||.:.| .:|:|:.|...||.||.|.|::|
  Fly   434 PLCHRPFGTRHNLKRHYMIHTGEKPFSCSKC---------------------------------- 464

  Fly   796 EQSKPKYQCGTCGKLLAKKYSLKLHEISHSKAVERNYLCHFADCSYAGRTPESLKTHL-VSHSQE 859
              .||..:|.|          ||.|.::|.:  :|.|.|.        |.|...:.:| .|..:.
  Fly   465 --RKPFRECST----------LKKHMVTHVR--DRWYKCL--------RCPSKFRDYLEYSDHKN 507

  Fly   860 NHKCARINCSYVGKSELHLKRHLKSAHSTEKNG----EEWFSCDQCDFR----ARIKGHLRRHSL 916
            ||             :..|.....|.:.::.:|    |:...|.:|..|    .....||::|.|
  Fly   508 NH-------------QDQLSSRKSSIYESDDDGDSSVEDCLECCECQQRFTELDAYTAHLKKHDL 559

  Fly   917 RHSG 920
            ...|
  Fly   560 ELYG 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	1/19 (5%)
		C2H2 Zn finger	731..750	CDD:275368	8/19 (42%)
		C2H2 Zn finger	758..779	CDD:275368	2/20 (10%)
		C2H2 Zn finger	804..824	CDD:275368	5/19 (26%)
		C2H2 Zn finger	834..856	CDD:275368	4/22 (18%)
		C2H2 Zn finger	898..918	CDD:275368	7/23 (30%)
		zf-H2C2_2	910..935	CDD:290200	5/11 (45%)
		C2H2 Zn finger	926..945	CDD:275368
		C2H2 Zn finger	957..984	CDD:275368
CG4496	NP_001285707.1	zf-C2H2	245..267	CDD:278523	7/22 (32%)
		C2H2 Zn finger	247..267	CDD:275368	7/20 (35%)
		zf-H2C2_2	259..282	CDD:290200	9/34 (26%)
		C2H2 Zn finger	275..295	CDD:275368	5/19 (26%)
		zf-C2H2	431..453	CDD:278523	8/21 (38%)
		C2H2 Zn finger	433..453	CDD:275368	8/19 (42%)
		zf-H2C2_2	445..468	CDD:290200	10/58 (17%)
		C2H2 Zn finger	461..481	CDD:275368	9/65 (14%)
		C2H2 Zn finger	489..510	CDD:275368	7/41 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100