DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and Zfp407

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	XP_008770443.2	Gene:	Zfp407 / 307213	RGDID:	1310645	Length:	2255	Species:	Rattus norvegicus

Alignment Length:	1350	Identity:	264/1350 - (19%)
Similarity:	414/1350 - (30%)	Gaps:	538/1350 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HLEDTH----LCIRCNATILGLSK--YIDHR---KRNCLITGKQNASPKTDGRTRISADTHVSAT 60
            |:::.|    .|..||   |.||:  ..:||   ..|.|:     ..|||  .:.:|.|:.:..:
  Rat   599 HMKEKHGMGFFCTSCN---LFLSERDVEEHRATEAHNSLV-----VQPKT--ASSLSRDSVLPLS 653

  Fly    61 LISSSNLDHSYDGFHFTEPEAPSSYLRKTAASHGG-----------------KTSKSLTEAYDLP 108
            .:.|.|:..|.:.......|.|:    ::.||||.                 ||..|......:.
  Rat   654 TLESDNMADSREDSGKASQEEPA----ESRASHGTEARHSSKPQFQCKKCFYKTRSSTVLTRHIK 714

  Fly   109 YELGADLFF--SSLQLQSVATGGKIGSVPRQERSKDESWSAPAGDPLLKAVRENDETVFKPLHFD 171
            ...|.|..|  .:..|.|::   |.|.....:|||.          |..|.:.|....|
  Rat   715 LRHGQDYHFLCKACNLYSLS---KEGMEKHIKRSKH----------LENAKKNNIGLSF------ 760

  Fly   172 HEYPEASDEEDDEDEHEEFDAEEDEEEYDARRHSPPIVPASHTGGKWKPEQRPQLR---HPHIER 233
                      ::..|.....|.:.:||             |:..|..:||....:|   |.|.|:
  Rat   761 ----------EECIERVCIGANDKKEE-------------SNVSGSGRPEGHIGVRLQEHSHCEQ 802

  Fly   234 --LSPSWDEPPEENYTHPPADHTKGKWVPGSKQLEYRENLDLTKLDQPGA--------------- 281
              |:|                    |.:|.|..:...:.|.|....:.|.
  Rat   803 SMLTP--------------------KELPQSGVITKEDELGLASTPKRGRPKGSISRTCSHCGLL 847

  Fly   282 -------------------SYWCNICCRRLKSRLYY-------NQHLRSGYHIKRAEAECELEQA 320
                               ||.|.:|       .||       .:|..:..|..|.|.|...:.:
  Rat   848 ASSITNLTVHIRRKHSHQYSYLCKVC-------KYYTVTKGDMERHCATKKHKGRVEIEANGKHS 905

  Fly   321 T---LGRE-------------LTLSKD---FSIKDDADKNEPKPPKRQRRANLLRCDLCRHTMAR 366
            :   :|.|             ||:|.:   .|.|.||.                       |:.:
  Rat   906 SDIIVGPEGGNLEACKKSTLALTVSDEQANKSAKSDAS-----------------------TLDK 947

  Fly   367 HLIGK-----------------HLISHYHFRR---------LQQQSRIRRQACLQEILKHMGSIV 405
            .::|.                 .:.|....::         |||..    .||.|.      .:.
  Rat   948 PVVGNGDTGDADAGSALQSVDGEVSSQLADKKGQIALETEDLQQHD----DACSQR------DVA 1002

  Fly   406 RQSPFQCMPCRFYANTEETFLYHWKSHEHLELTKRLGGTFWCSFCQFNSNTNNSMLLHLLDSSHK 470
            ..|..:|:.|.|.|::..:...|.| .:|   ||..  .|:|..|.:.:.|...|..|.....||
  Rat  1003 GSSDNKCLHCEFSAHSAASLELHVK-RKH---TKEF--EFYCMACDYYAVTRREMTRHAATEKHK 1061

  Fly   471 ----EVLLALN-------RSVPICIAQRRRIQCSRCGMEFLYNIQLRQHSI-----TEHP---GL 516
                ..|.:.|       .|..|.|.:....|.|.   ||    |:..|..     :.||   .:
  Rat  1062 MKRQSYLSSSNVEAGSSEISKSITIPEEEHSQNSE---EF----QISPHQSSGTLQSRHPADCSI 1119

  Fly   517 ALTGTAADEYQSRFRCNLCGSSQKSRLALQRHKKHKHHLARYFCAICR--LEFDNSLDARRHRSL 579
            ....|..|  .|:.   ||.....:.:|.|....::.|   .||....  |..|.|:..|...||
  Rat  1120 LYDNTNLD--MSKV---LCAPDSVAVVAEQESNFNEDH---SFCETLHQPLAKDRSIKPREIVSL 1176

  Fly   580 VIHKQKARPQTSIPQPENEIEHMLREVLEETVPSPPAKRS-------ADVNAKCSNSRKTIESSQ 637
            .....::.|  ...|..|        :....|.|..|||:       .|.:|.|.:...:::.|:
  Rat  1177 NTPSNRSSP--GCLQSGN--------LASSAVDSETAKRNHNLLDDVGDTSAHCEDEGGSLDGSE 1231

  Fly   638 RL------------AQHQAE--------------------------VHSSDNHLCLSCGISFESA 664
            ..            ..|.||                          ..:|::...:....:.||.
  Rat  1232 EKVLDKSPCPGDLDGGHSAESISPVVVKIPREQLDLDGGGQSKVGCEQTSEDLKDVQANSNLESK 1296

  Fly   665 QALGRHTRSCQPLASTSTPADLSQAQK--------------KSMYS------------------- 696
            :.|.......:.:.....||.:..|:.              ::|||
  Rat  1297 EILMNSQHEPEVILEEDAPASIGTAENNDAYETIISIDDKGQTMYSFGRFDSSIIRIKTEDGELV 1361

  Fly   697 -------------------------------------------CDQCRFQSQYESDLVYH-RIFH 717
                                                       ||.|.|.:...|.|..| .:.|
  Rat  1362 EQPEEGLMVTGGKVSELPLKDCAQGLKKKKVEGSSFGESTRIRCDDCGFLADGLSGLNVHIAMKH 1426

  Fly   718 TRSGTIGKNEVLQCPLCPKNF------KKHSLRA-HLRNH--TNEKI------FECTECLQKFAR 767
            ..     |.:...|.||.|:|      .:|...| |:||.  :.|::      |:|.:|.:.|..
  Rat  1427 PT-----KEKHFHCLLCGKSFYTESNLHQHLASAGHMRNEQASVEELPEGGATFKCVKCTEPFDS 1486

  Fly   768 RHNLKNHVITKHAKVGDKEKKKYAAKDVEQ----------------------------------- 797
            ..||..|:..:|.:: .:|..||..:|.||
  Rat  1487 EQNLFLHIKGQHEEL-LREVNKYIVEDTEQINREREENQGNVCKYCGKMCRSSNSMAFLAHIRTH 1550

  Fly   798 --SKP---------------------------KYQCGTCGKLLAKKYSLKLHEI-SHSKAV--ER 830
              |||                           :|:|..||.....|..|..|.: .|....  ||
  Rat  1551 TGSKPFKCKICHFATAQLGDARNHVKRHLGMREYKCHVCGVAFVMKKHLNTHLLGKHGVGTPKER 1615

  Fly   831 NYLCHFAD----------------------------CSYAGRTPESLKTHLVSHSQENHKCARIN 867
            .:.||..|                            |.|:..|..::|.|..:|:.|......:
  Rat  1616 KFTCHLCDRSFTEKWALNNHVKLHTGEKPFKCTWPTCHYSFLTASAMKDHYRTHTGEKSFLCDL- 1679

  Fly   868 CSYVGKSELHLKRHLKSAHSTEKNGEEWFSCDQCDFRARIKGHLRRHSLRHSGQKPHQCPHCDFQ 932
            |.:.|.:     ||..:.|..:..||:.|.||:|:|.:..:.||.||...|:|:||::||.||::
  Rat  1680 CGFAGGT-----RHALTKHRRQHTGEKPFKCDECNFASTTQSHLTRHKRVHTGEKPYRCPWCDYR 1739

  Fly   933 CSTIDNLRKHIIKTGKHPGMFIYHCAKCSDEEAGEIFKSNSYKEYQHHLK 982
            .:..:|:||||:.||||.|:.:|:|.||.       :.:|...|:::|||
  Rat  1740 SNCAENIRKHILHTGKHEGVKMYNCPKCD-------YGTNVPVEFRNHLK 1782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	7/20 (35%)
		C2H2 Zn finger	731..750	CDD:275368	9/25 (36%)
		C2H2 Zn finger	758..779	CDD:275368	6/20 (30%)
		C2H2 Zn finger	804..824	CDD:275368	6/20 (30%)
		C2H2 Zn finger	834..856	CDD:275368	8/49 (16%)
		C2H2 Zn finger	898..918	CDD:275368	8/19 (42%)
		zf-H2C2_2	910..935	CDD:290200	12/24 (50%)
		C2H2 Zn finger	926..945	CDD:275368	9/18 (50%)
		C2H2 Zn finger	957..984	CDD:275368	7/25 (28%)
Zfp407	XP_008770443.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6973
eggNOG	1	0.900	-	-		E33208_3BBQU
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900