DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and Zfp407

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_001028513.2	Gene:	Zfp407 / 240476	MGIID:	2685179	Length:	2246	Species:	Mus musculus

Alignment Length:	1386	Identity:	242/1386 - (17%)
Similarity:	403/1386 - (29%)	Gaps:	597/1386 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNE----DHLEDTH----LCIRCNATILGLSKYIDHR---KRNCLITGKQNASPKTDGRTRISAD 54
            :||    ||:::.|    .|..|| ..|......:||   ..|.|:     ..|||  .:.:|.|
Mouse   592 LNETGLRDHMKEKHGMGFFCTSCN-LFLSEKDVEEHRATESHNSLV-----VQPKT--ASSLSGD 648

  Fly    55 THVSATLISSSNLDHSYDGFHFTEPEAPSSYLRKTAASHGG-----------------KTSKSLT 102
            :.:..:.:.|.|...|.:.......|.|:    ::.||||.                 ||..|..
Mouse   649 SVLPFSTVESENPADSREDSGKAAQEGPA----ESRASHGTEARHSSKPQFQCKKCFYKTRSSTV 709

  Fly   103 EAYDLPYELGADLFF--SSLQLQSVATGGKIGSVPRQERSKDESWSAPAGDPLLKAVRENDETVF 165
            ....:....|.|..|  .:..|.|::   |.|.....:|||.          |..|.:.|....|
Mouse   710 LTRHIKLRHGQDYHFLCKACNLYSLS---KEGMEKHIKRSKH----------LENAKKNNIGLSF 761

  Fly   166 KPLHFDHEYPEASDEEDDEDEHEEFDAEEDEEEYDARRHSPPIVPASHTGGKWKPEQRPQLR-HP 229
                            ::..|.....|.:.:||             |...|..:||....:: ..
Mouse   762 ----------------EECIERVCIGANDKKEE-------------SSVSGSGRPEGHVGVQSQE 797

  Fly   230 HIERLSPSWDEPPEENYTHPPADHTKGKWVPGSKQLEYRENLDLTKLDQPGA------------- 281
            |.:|         |::...|       |.:|.|..:...:.|.|....:.|.
Mouse   798 HSQR---------EQSMLTP-------KELPQSGVITKEDELGLATTPKRGRPKGSISRTCSHCG 846

  Fly   282 ---------------------SYWCNICCRRLKSRLYY-------NQHLRSGYHIKRAEAECELE 318
                                 ||.|.:|       .||       .:|..:..|..|.|.|...:
Mouse   847 LLASSITNLTVHIRRKHSHQYSYLCKVC-------KYYTVTKGDMERHCATKKHKGRVEIEANGK 904

  Fly   319 QAT------LGRELTLSKDFS--IKDDADKNEPKPPKRQRRA----------------------- 352
            |::      .|..|...||.:  ....:|....||.|...|.
Mouse   905 QSSDIVVGPEGGNLEACKDSTSLAVTVSDAQASKPAKSDTRTLETPGVGIGNAGDAEAGSVFPSG 969

  Fly   353 ----------------------------------------NLLRCDLCRHTMARHLIGKHLISHY 377
                                                    ..|:|:...|:.|.        ...
Mouse   970 DGELSSQLSDKKGQLSLETEDLLQLDDACSQREVAGSSDNKCLQCEFSAHSAAS--------LEL 1026

  Fly   378 HFRRLQQQSRIRRQACLQEILKHMGSIVRQSPFQCMPCRFYANTEETFLYHWKSHEH-------- 434
            |.:|                 ||    .::..|.||.|.:||.|......|..:.:|
Mouse  1027 HVKR-----------------KH----TKEFQFYCMACDYYAVTRREMTRHAATEKHRMKRQSYL 1070

  Fly   435 ---------LELTKRL---------------------GGTFWC---------------------- 447
                     .|::|.:                     .||..|
Mouse  1071 SASSVEAGSSEISKNITIPEEEHSHNSEEFQIHPHQSSGTLQCRNPADCSILDDNTNLGMSKVLC 1135

  Fly   448 -------------------SFCQ-----------------FNSNTNNSMLL-------HLLDSS- 468
                               |||:                 .:.||.:::.|       :|..|:
Mouse  1136 APDSVTVVTEQESNFSEGHSFCETLQQPLVKDKSMKPREIVSPNTPSNLSLPGCLQSENLASSAV 1200

  Fly   469 -------HKEVLLAL-NRSVP-------ICIAQRRRIQCSRC----------------------- 495
                   :::||.|: :||.|       :..::.:.:..|.|
Mouse  1201 DCETAKKNRDVLDAVGDRSTPCEDEGGSVDDSEEKILDKSPCPGDPDGGHSAESTSSVVMKIPRE 1265

  Fly   496 -------------------------------GMEFLYN--------------------------- 502
                                           ..|.|.|
Mouse  1266 QLDLDGGGQNKVGCEQTSEDLKDVQANPILENKEILINSQEEAEVILEEDAPTSNGTADSNDVYE 1330

  Fly   503 ------------------------IQLRQHSITEHP--GLALTGTAADEY--------------- 526
                                    |:.....:.|.|  ||..||....|.
Mouse  1331 TIISIDDKGQTMYSFGRFDSSIIRIKTEDGELVEQPEEGLTATGGRVSELPLKDCAQGLKKKKVE 1395

  Fly   527 ------QSRFRCNLCG------SSQKSRLALQRHKKHKHHLARYFCAICRLEFDNSLDARRHRSL 579
                  .:|.||:.||      |.....:|::...|.||    :.|.:|...|....:..:|.:.
Mouse  1396 GGSFGESTRIRCDDCGFLADGLSGLNVHIAMKHPTKEKH----FHCLLCGKSFYTESNLHQHLAS 1456

  Fly   580 VIHKQKARPQTSIPQPENEIEHMLREVLEETVPSPPAKRSADVNAKCSNSRKTIESSQRL----- 639
            ..|.:  ..|.|:                |.:|...|      ..||....:..:|.|.|
Mouse  1457 AGHMR--NEQASV----------------EELPEGGA------TFKCVKCTEPFDSEQNLFLHIK 1497

  Fly   640 AQHQAEVHSSDNHLCLSCGISFESAQALGRHTRSCQPLASTSTPADLSQAQKKSMYSCDQCRFQS 704
            .||:..:...:.::       .|..:.:.|                  :.::.....|..|....
Mouse  1498 GQHEELLREVNKYI-------VEDTEQINR------------------EREENQGNVCKYCGKMC 1537

  Fly   705 QYESDLVYHRIFHTRSGTIGKNEVLQCPLCPKNFKKHSL---RAHLRNHTNEKIFECTECLQKFA 766
            :..:.:.:  :.|.|:.|..|  ..:|.:|  :|....|   |.|::.|...:.::|..|...|.
Mouse  1538 RSSNSMAF--LAHIRTHTGSK--PFKCKIC--HFATAQLGDARNHVKRHLGMREYKCHVCGVAFV 1596

  Fly   767 RRHNLKNHVITKHAKVGDKEKKKYAAKDVEQSKPKYQCGTCGKLLAKKYSLKLHEISHSKAVERN 831
            .:.:|..|::.||.....||:             |:.|..|.:...:|::|..|...|:.  |:.
Mouse  1597 MKKHLNTHLLGKHGVGTPKER-------------KFTCHLCDRSFTEKWALNNHMKLHTG--EKP 1646

  Fly   832 YLCHFADCSYAGRTPESLKTHLVSHSQENHKCARINCSYVGKSELHLKRHLKSAHSTEKNGEEWF 896
            :.|.:..|.|:..|..::|.|..:|:.|......: |.:.|.:     ||..:.|..:..||:.|
Mouse  1647 FKCTWPTCHYSFLTASAMKDHYRTHTGEKSFLCDL-CGFAGGT-----RHALTKHRRQHTGEKPF 1705

  Fly   897 SCDQCDFRARIKGHLRRHSLRHSGQKPHQCPHCDFQCSTIDNLRKHIIKTGKHPGMFIYHCAKCS 961
            .||:|:|.:..:.||.||...|:|:||::||.||::.:..:|:||||:.||||.|:.:|:|.||.
Mouse  1706 KCDECNFASTTQSHLTRHKRVHTGEKPYRCPWCDYRSNCAENIRKHILHTGKHEGVKMYNCPKCD 1770

  Fly   962 DEEAGEIFKSNSYKEYQHHLK 982
                   :.:|...|:::|||
Mouse  1771 -------YGTNVPVEFRNHLK 1784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	2/19 (11%)
		C2H2 Zn finger	731..750	CDD:275368	6/21 (29%)
		C2H2 Zn finger	758..779	CDD:275368	5/20 (25%)
		C2H2 Zn finger	804..824	CDD:275368	5/19 (26%)
		C2H2 Zn finger	834..856	CDD:275368	6/21 (29%)
		C2H2 Zn finger	898..918	CDD:275368	8/19 (42%)
		zf-H2C2_2	910..935	CDD:290200	12/24 (50%)
		C2H2 Zn finger	926..945	CDD:275368	9/18 (50%)
		C2H2 Zn finger	957..984	CDD:275368	8/26 (31%)
Zfp407	NP_001028513.2	C2H2 Zn finger	180..200	CDD:275368
		C2H2 Zn finger	209..230	CDD:275368
		C2H2 Zn finger	524..552	CDD:275371
		C2H2 Zn finger	553..575	CDD:275371
		C2H2 Zn finger	1407..1436	CDD:275371	8/32 (25%)
		C2H2 Zn finger	1437..1459	CDD:275371	4/21 (19%)
		C2H2 Zn finger	1479..1500	CDD:275371	4/20 (20%)
		C2H2 Zn finger	1530..1552	CDD:275368	4/23 (17%)
		zf-H2C2_2	1548..1569	CDD:290200	7/24 (29%)
		C2H2 Zn finger	1560..1580	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1588..1608	CDD:275368	5/19 (26%)
		COG5048	<1618..1737	CDD:227381	37/126 (29%)
		C2H2 Zn finger	1621..1641	CDD:275368	5/19 (26%)
		zf-H2C2_2	1633..1660	CDD:290200	7/28 (25%)
		C2H2 Zn finger	1649..1671	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1679..1699	CDD:275368	5/25 (20%)
		zf-H2C2_2	1691..1716	CDD:290200	8/24 (33%)
		COG5048	1703..>1758	CDD:227381	24/54 (44%)
		C2H2 Zn finger	1707..1727	CDD:275368	8/19 (42%)
		zf-H2C2_2	1719..1744	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1735..1752	CDD:275368	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBQU
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5693
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.850