DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31612 and Zbtb17

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_001365755.1	Gene:	Zbtb17 / 22642	MGIID:	107410	Length:	819	Species:	Mus musculus

Alignment Length:	456	Identity:	113/456 - (24%)
Similarity:	174/456 - (38%)	Gaps:	129/456 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   612 PSPPAKRS--ADVNAKCSNSRK--TIE------SSQRLAQHQAEVHSSDNHLCLSCGISFESAQ- 665
            |:|.::.|  |:...|....|:  .:|      ||...|:.:|...||:..:.:......|..|
Mouse   195 PNPASRPSSGAEQTEKADAPREPPPVELKPDPTSSMAAAEAEALSESSEQEMEVEPASKGEDGQE 259

  Fly   666 ----------ALGRHTRSCQPLASTSTPADLSQAQKKSMYSCDQCRFQSQYESDLVYHRIFHTRS 720
                      ..|.|..:.:|.......|.....|:..|        :.|           :.||
Mouse   260 EEGAGPATVKEEGMHLDNGEPPEENEESAGTDSGQELGM--------EGQ-----------NLRS 305

  Fly   721 GTIGKNE--------VLQCPLCPKNFKKH--SLRAHLRNHTNEKIFECTECLQKFARRHNLKNHV 775
            ||.|...        :.:|..|.|.| .|  :.:.|:|.||.||.|.|.||.:.|:.....|.|.
Mouse   306 GTYGDRTESKAYGSIIHKCEDCGKEF-THTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHE 369

  Fly   776 ITKHAKVGDKEKKKYAAKDVEQS----------------KPKYQCGTCGKLLAKKYSLKLHEISH 824
            .| |:.:     |.|..::..:|                :.:|:||.||||.....:||.|::.|
Mouse   370 KT-HSPL-----KPYGCEECGKSYRLISLLNLHKKRHSGEARYRCGDCGKLFTTSGNLKRHQLVH 428

  Fly   825 SKAVERNYLCHFADCSYAGRT---PESLKTHLVSH-SQENHKCARINCSY--VGKSELHLKRHLK 883
            |.  ::.|     .|.|.||:   |.|...||.:| :.:.|||...:..:  ||..:.|||.|:.
Mouse   429 SG--QKPY-----QCDYCGRSFSDPTSKMRHLETHDTDKEHKCPHCDKKFNQVGNLKAHLKIHIA 486

  Fly   884 SAHSTEKNGEEWFSCDQCDFRARIKGHLRRHSLRHSGQKPHQCPHCDFQCSTIDNLRKHI-IKTG 947
            ...         ..|.:|..:....|:|:||...|||:||:.|.||..|.:....|::|: |.||
Mouse   487 DGP---------LKCRECGKQFTTSGNLKRHLRIHSGEKPYVCTHCQRQFADPGALQRHVRIHTG 542

  Fly   948 ------------------------KHPGMFIYHCAKCSDEEAGEIFKSNSY--KEYQHH--LKTH 984
                                    :|.|...|.|.:|     |:.|..:|.  ...:||  ::.|
Mouse   543 EKPCQCVICGKAFTQASSLIAHVRQHTGEKPYVCERC-----GKRFVQSSQLANHIRHHDNIRPH 602

  Fly   985 K 985
            |
Mouse   603 K 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	1/19 (5%)
		C2H2 Zn finger	731..750	CDD:275368	7/20 (35%)
		C2H2 Zn finger	758..779	CDD:275368	7/20 (35%)
		C2H2 Zn finger	804..824	CDD:275368	9/19 (47%)
		C2H2 Zn finger	834..856	CDD:275368	8/24 (33%)
		C2H2 Zn finger	898..918	CDD:275368	6/19 (32%)
		zf-H2C2_2	910..935	CDD:290200	12/24 (50%)
		C2H2 Zn finger	926..945	CDD:275368	6/19 (32%)
		C2H2 Zn finger	957..984	CDD:275368	7/30 (23%)
Zbtb17	NP_001365755.1	BTB_POZ_ZBTB17_MIZ1	2..113	CDD:349515
		PRK07003	<115..>266	CDD:235906	15/70 (21%)
		COG5048	322..653	CDD:227381	86/310 (28%)
		C2H2 Zn finger	324..344	CDD:275368	7/20 (35%)
		C2H2 Zn finger	352..372	CDD:275368	7/20 (35%)
		C2H2 Zn finger	380..400	CDD:275368	1/19 (5%)
		C2H2 Zn finger	408..428	CDD:275368	9/19 (47%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	464..484	CDD:275368	6/19 (32%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	548..568	CDD:275368	0/19 (0%)
		C2H2 Zn finger	576..596	CDD:275368	5/24 (21%)
		C2H2 Zn finger	604..624	CDD:275368	113/456 (25%)
		C2H2 Zn finger	632..651	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100