DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and Wiz

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	XP_036016381.1	Gene:	Wiz / 22404	MGIID:	1332638	Length:	1871	Species:	Mus musculus

Alignment Length:	964	Identity:	182/964 - (18%)
Similarity:	289/964 - (29%)	Gaps:	380/964 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 DGRTRISADTHVSATLISSSNLDHSYDGFHFTEPEAPSSYLRKTAASHGGKTSKSLTEAYDLPYE 110
            |||:.||                   ||  ...|....:..|.|:|:|  :.|....:...|.::
Mouse    56 DGRSGIS-------------------DG--QPHPGLSEALPRATSATH--RISSCYWDGDSLDFQ 97

  Fly   111 LGA------DLFFSSLQLQSVATGGKIGSVPRQERSKDESWSAPAGDPLLKAVRE--------ND 161
            .|:      ..|.:||.:|.                   ||.    .|:::..||        .|
Mouse    98 PGSPPPHLLGPFPASLDVQG-------------------SWE----HPMVQEAREGTPSEQRFKD 139

  Fly   162 ETVFKPL----------HFDHEYPEASDEEDDEDEHEEFDAEEDEEEYDARRHSPPIVPASHTGG 216
            ..:.:.:          .|.|...|....|.....|.:||..:|.:|..         |...||
Mouse   140 SVIVRTMKPYAKLKGSRKFLHHQGEVKFLEKYSPSHHKFDWLQDTDEQG---------PLKDTG- 194

  Fly   217 KWKPEQRPQLRHPHIERLSPSWDEPPEENYTH---PPADHTKGKWVPGSKQLEY---RENL-DLT 274
                        .|::  .|:  :||......   .|.|:|     |.:..:|.   ||:| |..
Mouse   195 ------------LHLD--LPA--QPPTVTSFRRVIVPVDNT-----PKTLDMEVMGTREDLEDFG 238

  Fly   275 KLDQPGASYW-----------------CNICCRRLKSRLYYNQHLRSGYHIKRAEAECELEQATL 322
            ::.||  |.|                 ......||:..|   ..:::|.::      |||.|...
Mouse   239 QVAQP--SEWGLHTSASEVATQTWTVNSEASVERLQPLL---SPVQTGPYL------CELLQEVA 292

  Fly   323 GRELTLSKDFSIKDDADKNEPKPPKRQRRANLLRCDLC----RHTMARHLIGKHLISHYHFRRLQ 383
            |             ..|.||    :.:....:..|..|    :|.       :||:.|     :.
Mouse   293 G-------------GVDSNE----EEEEEPAVFPCIECSIYFKHK-------EHLLEH-----MS 328

  Fly   384 QQSRIRRQACLQEILKHMGSIVRQSPFQCMPCRFYANTEETFL-YHWKSH--------EHLELTK 439
            |..|...|....::          :|..|..|. :|.||.|.| .||:.|        |.::..|
Mouse   329 QHRRAPGQEPPADL----------APLACSECG-WAFTEPTALEQHWQLHQASREKIIEEIQKLK 382

  Fly   440 RLGG------TFWCSFCQFNSNTNNSMLLHLLDSSHKEVLLALNRSVPICIAQRRRIQCSRCGME 498
            :..|      ...||.|.|.:|::.:.:.|        ..|.:..|:|    .|:..:..|.|..
Mouse   383 QFPGDEGREARLQCSKCVFGTNSSRAFMQH--------AKLHVRGSLP----SRQATEPFRGGSP 435

  Fly   499 FLYNIQLRQHSITEHPGLALTGTAADEYQSRFRCNLCGSSQKSRLALQRHKK--HKHH------- 554
            .|....|...|..:..||.             .|..||.:..|:..|:.|.:  |.||
Mouse   436 VLDVSTLVYPSYGDSSGLN-------------TCVHCGFTAPSKSLLREHTRLVHAHHAHWEEVG 487

  Fly   555 -----LARYFCAICRLEFDNSLDARRHRSLVIHKQKARPQTSIPQPENEIEHMLREVLEE----- 609
                 |....|        .|.||..|          .|.|:.....::.|.:|..|.:|
Mouse   488 EAFEDLTSQPC--------TSQDAYTH----------SPDTATVDYFSKSEPLLASVWQENPSGY 534

  Fly   610 -------------------------------TVPSPPAKRSADVNAKCSNSRKTI-----ESSQR 638
                                           ..|||.|  ||..:.:.:.::.|:     |....
Mouse   535 DPDLAFGPDYQQPGMRNFPLLNSGQQSLGKLAFPSPMA--SASYSIQRNRNKSTVHLQRMEDKSH 597

  Fly   639 LAQHQAEVHSSDNHLCLSCGISFESAQALGRHTRSCQPLASTS---TPA-DLSQAQKKSMYSCDQ 699
            |...:.|....|        :...|.:.......:..|||..|   .|| :|.|..:.::.:.|.
Mouse   598 LWSEEEEEEDED--------VVLTSERDFTPENGAFPPLAIPSLIPQPALELKQTFQDALQAVDA 654

  Fly   700 CRFQSQYESDLVYHRIF----------HTRS---------------------------GTIGKNE 727
            ...|.|....:|...:.          .||:                           |::|.|.
Mouse   655 SETQQQQLQGMVPIVLMAKLRPQVIAATTRASPQLPPEEPELRSTHPLDFLLLDAPLGGSLGLNT 719

  Fly   728 VLQ-------------CPLCPKNFKKHS---LRAHLRNHTNEKIFECTECLQKFARRHNLKNHVI 776
            :|:             ||.||..|  |:   |..|:|.|.|           :....:|:::.:.
Mouse   720 LLEGDPAMALKHEERKCPYCPDRF--HNGIGLANHVRGHLN-----------RVGVSYNVRHFIS 771

  Fly   777 TKHAKVGD------KEKKKYAAKDVEQSKPKYQCGTCGKLLAKKYSLKLHEISH 824
            .:..|..:      |:|||.|..| ..:....:|..||.....:..|..|..:|
Mouse   772 AEEVKAIERRFSFQKKKKKVANFD-PGTFSLMRCDFCGAGFDTRAGLSSHARAH 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	4/29 (14%)
		C2H2 Zn finger	731..750	CDD:275368	9/21 (43%)
		C2H2 Zn finger	758..779	CDD:275368	1/20 (5%)
		C2H2 Zn finger	804..824	CDD:275368	5/19 (26%)
		C2H2 Zn finger	834..856	CDD:275368
		C2H2 Zn finger	898..918	CDD:275368
		zf-H2C2_2	910..935	CDD:290200
		C2H2 Zn finger	926..945	CDD:275368
		C2H2 Zn finger	957..984	CDD:275368
Wiz	XP_036016381.1	C2H2 Zn finger	310..330	CDD:275368	6/31 (19%)
		C2H2 Zn finger	347..367	CDD:275368	9/20 (45%)
		C2H2 Zn finger	396..416	CDD:275368	6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000