DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and ztf-15

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_492052.2	Gene:	ztf-15 / 172470	WormBaseID:	WBGene00011066	Length:	729	Species:	Caenorhabditis elegans

Alignment Length:	893	Identity:	172/893 - (19%)
Similarity:	275/893 - (30%)	Gaps:	344/893 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 VRENDETVFKPL------HFDHEYP-------------EAS----------------DEEDDEDE 186
            :.|:|:||..|.      .|.|:.|             |||                .||.::.|
Worm     1 MEESDQTVLLPNVENEIGSFYHDMPDEKLLRHIKAIFDEASLRPSLTKNVPSTSSQVTEELNKVE 65

  Fly   187 HEEFDAEEDEEEYDARRHSPPIVPASHTGG--KWKPEQRPQLRHPHIERL--------------- 234
            ..:...|..:|:|.:...:|..|..:...|  .|...........:|..|
Worm    66 IRDPKHEMQDEQYLSIFENPSGVQYNQADGSFSWNNRFHSDNSVQYINVLNNYGCEGADTLLNQS 130

  Fly   235 --SPSWDEPPEENYTHPPADHTKGKWVPGSKQLEYRENLDLTKLDQPGASYW------------C 285
              |...||..||..|  |.         |::|  .|.||    ..:|.|.||            |
Worm   131 DSSDETDESIEERRT--PR---------GNRQ--SRSNL----TSKPSAKYWTKRGGDPIVNCSC 178

  Fly   286 NICCRRLKSRLYYNQHLRSGYHIKRAEAECELEQATLGRELTLSKDFSIKDDADKNEPKPPKRQR 350
            :||..:..:                  ..|.|:..        .::.|:||
Worm   179 SICGSKFST------------------IRCLLDHR--------HQEHSLKD-------------- 203

  Fly   351 RANLLRCDLCRHTMARHLIGKHLISHYH-FRRLQQQSRIRRQACLQEILKHMGSIVRQSPFQCMP 414
               ::.|.||         ||......| :..|.|:.::                     :.|..
Worm   204 ---MMMCGLC---------GKEFSKRTHIYLHLSQEYKV---------------------YHCDG 235

  Fly   415 CRFYANTEETFLYHWKSHEHLE-------LTKRLGGTFWCSFCQFNSNTNNSMLLHLLDSSHKEV 472
            |    ||.....:|.:.|...|       ..:|.|        :.|:.....:...:.|.....|
Worm   236 C----NTSFASKWHLEKHRCKENETIDDKKRRRTG--------RVNAEEIKVIKEEIQDEEFGGV 288

  Fly   473 LLALNRSVPICIAQRRRIQCSRCGMEFLYNIQLRQHSITEHPGLALTGTAADEYQSRFRCNLCGS 537
            :|: |.:.......|.:..|..||.::.:     .|.:.:|....|..|  ||.| .|:||:|..
Worm   289 VLS-NENHEKSKEDRFQFACVLCGKKYQH-----YHWLLKHRTKCLETT--DEIQ-EFKCNVCYR 344

  Fly   538 SQKSRLALQR-------------------------HKK---------HKHHLARYFCAICRLEFD 568
            ...|....:|                         |||         ||.|......|:..:..|
Worm   345 RYNSSFWFERHMEKCNSSTALPPALLDQTISCPNCHKKYQNEYWFDYHKKHCPDITPALSDVHLD 409

  Fly   569 -NSLDARRHR----SLVIHKQKARPQTSI--PQPENEIEHMLREVLEETVPSPPAKRSADVNAKC 626
             |||..||.|    |:|       |..::  .:||.|.::...|..:.|:.|..:.....||..|
Worm   410 VNSLRDRRPREGEISVV-------PDVNLFGIEPEREDDNDDDEDADATISSSSSSTGNLVNIPC 467

  Fly   627 SNSRKTIESSQRLAQHQAEVHSSDNHLCLSCGI---SFESAQALGRHTRSCQPLASTSTPADLSQ 688
            |...|.......|..|:.::|...  ..|:||:   .|.:..::.||                 .
Worm   468 SICGKFCVGVASLLHHRKQIHGLT--AMLTCGVCTKKFNTLSSIRRH-----------------M 513

  Fly   689 AQKKSMYSCDQCRFQSQYESDLVYHRIFHTRSGTIGKNEVLQCPL----CPKNFKKHSLR-AHLR 748
            :.:.|::.|.||                       |:|.:.:..|    |   ||.:.:| ..|.
Worm   514 SMEYSIFRCQQC-----------------------GRNCIDRTTLDRHEC---FKPYKIRDKRLF 552

  Fly   749 NHTNEKIFECTECLQKFARRHNLKNHVIT-KHAKVGDKEKKKYAAKDVEQSKPKYQCGTCGKLLA 812
            |..|..:.:|.:|...||..:.|..|..| ::..|.|         :::|....
Worm   553 NIQNISVLKCPDCRATFANLNVLSEHRKTCQYGNVFD---------NIQQPGSS----------- 597

  Fly   813 KKYSLKLHEIS--HSKAVERNYLCHFADCSYAGRTPESLKTHLVSHSQENHKCARINCSYVGKSE 875
               ||:.|..|  :..|::|..               :.:..|.|::.|...|...:.|:.....
Worm   598 ---SLRQHHRSDTNGAALQRKI---------------TSRVRLDSNTPEKWTCRDCHASFHNLQA 644

  Fly   876 LHLKRHLKSAHSTEKNGEEWFSCDQC-----DFRARIKGHLRRHSLRH 918
            |...||       |.:|:|.|.|:.|     ::||     |..|::.|
Worm   645 LCSHRH-------ESHGKEMFQCNNCSETLPNYRA-----LHDHNMMH 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	3/19 (16%)
		C2H2 Zn finger	731..750	CDD:275368	6/23 (26%)
		C2H2 Zn finger	758..779	CDD:275368	7/21 (33%)
		C2H2 Zn finger	804..824	CDD:275368	4/21 (19%)
		C2H2 Zn finger	834..856	CDD:275368	1/21 (5%)
		C2H2 Zn finger	898..918	CDD:275368	6/24 (25%)
		zf-H2C2_2	910..935	CDD:290200	3/9 (33%)
		C2H2 Zn finger	926..945	CDD:275368
		C2H2 Zn finger	957..984	CDD:275368
ztf-15	NP_492052.2	C2H2 Zn finger	178..199	CDD:275368	5/46 (11%)
		C2H2 Zn finger	207..223	CDD:275368	6/24 (25%)
		C2H2 Zn finger	233..250	CDD:275368	5/20 (25%)
		SFP1	<337..395	CDD:227516	11/57 (19%)
		C2H2 Zn finger	467..488	CDD:275368	5/20 (25%)
		C2H2 Zn finger	496..514	CDD:275368	5/34 (15%)
		C2H2 Zn finger	522..538	CDD:275368	6/38 (16%)
		C2H2 Zn finger	562..581	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100