DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31612 and ZFP28

DIOPT Version :9

Sequence 1:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster
Sequence 2:	NP_065879.1	Gene:	ZFP28 / 140612	HGNCID:	17801	Length:	868	Species:	Homo sapiens

Alignment Length:	979	Identity:	209/979 - (21%)
Similarity:	314/979 - (32%)	Gaps:	296/979 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RKRNCLIT-GKQNASPKTDG-RTRISADT--------------------HVSATLISSSN--LDH 69
            |.||.|.: |::.|:|...| |...|.||                    .:|..|::..:  :|.
Human    48 RSRNGLASKGQRGAAPTGPGHRALPSRDTALPQERNKKLEAVGTGIEPKAMSQGLVTFGDVAVDF 112

  Fly    70 SYDGFHFTEPEAPSSYLRKTAASHGGKTSKSLTEAYDLPYELGADLFFSSLQLQSVATGGKIGSV 134
            |.:.:.:..|...:.|            .|.:.|.|.....||  |..|...:.|....||
Human   113 SQEEWEWLNPIQRNLY------------RKVMLENYRNLASLG--LCVSKPDVISSLEQGK---- 159

  Fly   135 PRQERSKDESWSAP-----AGDPLLKAVRENDETVFKPLHFDHEYPEASDEEDDEDEHEEFDAEE 194
                    |.|:..     |..|.||||.:..|...|....:.:..:|...|.....:.|:....
Human   160 --------EPWTVKRKMTRAWCPDLKAVWKIKELPLKKDFCEGKLSQAVITERLTSYNLEYSLLG 216

  Fly   195 DEEEYDARRHSPP-IVPASHTGGKWKPEQRPQLRHPHIERLSPS--WDEPPEENYTHPPADHTKG 256
            :..:|||...:.| :|...:..    .:.|.|| ||..:....:  |    |.|.....|.|...
Human   217 EHWDYDALFETQPGLVTIKNLA----VDFRQQL-HPAQKNFCKNGIW----ENNSDLGSAGHCVA 272

  Fly   257 K-------------W-----VPGS----------------KQLEYRENL----DLTKLDQPGASY 283
            |             |     :.||                ||..|.|.:    ..||||
Human   273 KPDLVSLLEQEKEPWMVKRELTGSLFSGQRSVHETQELFPKQDSYAEGVTDRTSNTKLD------ 331

  Fly   284 WCNICCRRLKSRLYYNQHLRSGYHIKRAEAECELEQATLGRELTLSKD-----------FSIKDD 337
             |:.......|...:.:.|..|       .|.:..|..:....||||:           |.:
Human   332 -CSSFRENWDSDYVFGRKLAVG-------QETQFRQEPITHNKTLSKERERTYNKSGRWFYL--- 385

  Fly   338 ADKNEPKPPKRQRRANLLRCDLCRHTMARHLIGKHLISHYHFRRLQQQSRIRRQACLQEILKHMG 402
             |.:|.|...|....|.                             |:|.:        ::|..|
Human   386 -DDSEEKVHNRDSIKNF-----------------------------QKSSV--------VIKQTG 412

  Fly   403 SIVRQSPFQCMPCRFYANTEETFLYHWKSHEHLELTKRLGGTFWCSFCQFNSNTNNSMLLHLLDS 467
            ....:..|:|..|:.......:...|.:.|...:..|       |:.|....:..:|...|
Human   413 IYAGKKLFKCNECKKTFTQSSSLTVHQRIHTGEKPYK-------CNECGKAFSDGSSFARH---- 466

  Fly   468 SHKEVLLALNRSVPICIAQRRRIQCSRCGMEFLYNIQLRQHSITEHPGLALTGTAADEYQSRFRC 532
                         ..|...::..:|..||..|:.|..|.:|....|.|           :..|.|
Human   467 -------------QRCHTGKKPYECIECGKAFIQNTSLIRHWRYYHTG-----------EKPFDC 507

  Fly   533 NLCGSSQKSRLALQRHKKHKHHLARYFCAICRLEFDNSLDARRHRSLVIHKQKARPQTSIPQPEN 597
            ..||.:....:.|.:|::.......|.|.:|...|      |...||.:|::       |...|.
Human   508 IDCGKAFSDHIGLNQHRRIHTGEKPYKCDVCHKSF------RYGSSLTVHQR-------IHTGEK 559

  Fly   598 EIEHMLREVLEETVPSPPAKRSADVNAKCSNSRKTIESSQRLAQHQAEVHSSDNHL-CLSCGISF 661
            ..|                         |...||.......|.||| .|||.:... |..||.:|
Human   560 PYE-------------------------CDVCRKAFSHHASLTQHQ-RVHSGEKPFKCKECGKAF 598

  Fly   662 ESAQALGRHTRSCQPLASTSTPADLSQAQKKSMYSCDQCRFQSQYESDLVYHRIFHTRSGTIGKN 726
            .....|..|.|             :...:|.  :.|.:|.......|.|..|:..||      ..
Human   599 RQNIHLASHLR-------------IHTGEKP--FECAECGKSFSISSQLATHQRIHT------GE 642

  Fly   727 EVLQCPLCPKNF-KKHSLRAHLRNHTNEKIFECTECLQKFARRHNLKNHVITKHAKVGDKEKKKY 790
            :..:|.:|.|.| :|..|..|.:.||.||.:||.||.:.|::    ..|:| :|.:|...||
Human   643 KPYECKVCSKAFTQKAHLAQHQKTHTGEKPYECKECGKAFSQ----TTHLI-QHQRVHTGEK--- 699

  Fly   791 AAKDVEQSKPKYQCGTCGKLLAKKYSLKLHEISHSKAVERNYLCHFADCSYAGRTPESLKTHLVS 855
                      .|:|..|||......|...|:..|:.  :|.|.|  .:|..|.:|..||..|..|
Human   700 ----------PYKCMECGKAFGDNSSCTQHQRLHTG--QRPYEC--IECGKAFKTKSSLICHRRS 750

  Fly   856 HSQENHKCARINCSYVGKSELHLKRHLKSAHSTEKNGEEWFSCDQCDFRARIKGHLRRHSLRHSG 920
            |:.|.    ...||..||:..|  |...|.|....:|::.:.|.:|.......|||.:|...|:|
Human   751 HTGEK----PYECSVCGKAFSH--RQSLSVHQRIHSGKKPYECKECRKTFIQIGHLNQHKRVHTG 809

  Fly   921 QKPH 924
            ::.:
Human   810 ERSY 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	5/19 (26%)
		C2H2 Zn finger	731..750	CDD:275368	7/19 (37%)
		C2H2 Zn finger	758..779	CDD:275368	6/20 (30%)
		C2H2 Zn finger	804..824	CDD:275368	6/19 (32%)
		C2H2 Zn finger	834..856	CDD:275368	7/21 (33%)
		C2H2 Zn finger	898..918	CDD:275368	6/19 (32%)
		zf-H2C2_2	910..935	CDD:290200	5/15 (33%)
		C2H2 Zn finger	926..945	CDD:275368
		C2H2 Zn finger	957..984	CDD:275368
ZFP28	NP_065879.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82		12/33 (36%)
		KRAB	103..163	CDD:214630	15/85 (18%)
		KRAB	103..142	CDD:279668	7/50 (14%)
		KRAB	232..288	CDD:214630	12/64 (19%)
		KRAB	232..266	CDD:279668	9/42 (21%)
		COG5048	417..806	CDD:227381	119/511 (23%)
		zf-C2H2	420..442	CDD:278523	4/21 (19%)
		C2H2 Zn finger	422..442	CDD:275368	3/19 (16%)
		zf-H2C2_2	434..458	CDD:290200	5/30 (17%)
		C2H2 Zn finger	450..470	CDD:275368	4/36 (11%)
		zf-H2C2_2	462..487	CDD:290200	7/41 (17%)
		C2H2 Zn finger	478..496	CDD:275368	7/17 (41%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
		zf-H2C2_2	520..544	CDD:290200	6/29 (21%)
		C2H2 Zn finger	535..555	CDD:275368	7/32 (22%)
		zf-H2C2_2	547..572	CDD:290200	9/56 (16%)
		C2H2 Zn finger	563..583	CDD:275368	7/20 (35%)
		zf-H2C2_2	575..600	CDD:290200	11/25 (44%)
		C2H2 Zn finger	591..611	CDD:275368	7/32 (22%)
		zf-H2C2_2	603..627	CDD:290200	6/38 (16%)
		C2H2 Zn finger	619..639	CDD:275368	5/19 (26%)
		zf-H2C2_2	632..656	CDD:290200	8/29 (28%)
		C2H2 Zn finger	647..667	CDD:275368	7/19 (37%)
		zf-H2C2_2	659..684	CDD:290200	11/24 (46%)
		C2H2 Zn finger	675..695	CDD:275368	7/24 (29%)
		zf-H2C2_2	687..710	CDD:290200	11/36 (31%)
		C2H2 Zn finger	703..723	CDD:275368	6/19 (32%)
		zf-H2C2_2	718..740	CDD:290200	7/25 (28%)
		C2H2 Zn finger	731..751	CDD:275368	7/21 (33%)
		zf-H2C2_2	743..768	CDD:290200	10/28 (36%)
		C2H2 Zn finger	759..779	CDD:275368	8/21 (38%)
		zf-H2C2_2	771..796	CDD:290200	5/24 (21%)
		C2H2 Zn finger	787..807	CDD:275368	6/19 (32%)
		C2H2 Zn finger	815..835	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000