DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1416 and AHSA1

DIOPT Version :9

Sequence 1:	NP_610121.2	Gene:	CG1416 / 35426	FlyBaseID:	FBgn0032961	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_036243.1	Gene:	AHSA1 / 10598	HGNCID:	1189	Length:	338	Species:	Homo sapiens

Alignment Length:	353	Identity:	149/353 - (42%)
Similarity:	211/353 - (59%)	Gaps:	19/353 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKWGEGDPRWIVEERPDATNVNNWHWTEKNATPWSKDRLHQLFQDFKIGQSDIECAVDSVDKCS 65
            ||||||||||||||||.||||||||||||::|:.||.|:|..||...::...:.:|.|..|.|..
Human     1 MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLD 65

  Fly    66 GEATVNNRKGKLIFFYEWELVLKWSGKLLKNSKLIHKGKLTIPNLSEENELADVEITVTIDESND 130
            |||::|||||||||||||.:.|.|:|  ...|.:.:||.:.|||||:||.:.:|||:|::  :.|
Human    66 GEASINNRKGKLIFFYEWSVKLNWTG--TSKSGVQYKGHVEIPNLSDENSVDEVEISVSL--AKD 126

  Fly   131 ESET-LKQFMYNVGRDRVRQQLASYIRELKEEYSKNLILPKKGDEA--GAGNTVANFKDANNTRN 192
            |.:| |...|...|...:|:.:..||..||.|:::.:|||....|:  ..|      :.|..|..
Human   127 EPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVG------QPALKTEE 185

  Fly   193 AAQNIALNSSVAAPRLKNSGIGCKLDVRTLSMTEEFHCSANDLYNALTKPEMVTAFTRAPAKVDA 257
            .....|.:.:.|.|      :|.|:....:::.|.|..|..:||...|..|:|.|||.|||.::|
Human   186 RKAKPAPSKTQARP------VGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEA 244

  Fly   258 VRGGEFILYGGNVLGKFEELVPEKKIQQSWRLKNWTSGHYSNVVIELEETSSSTMMSLKQTGIPA 322
            .|||:|.:..|||.|:|.:|||||.|...||.|:|..||::.:.:...:.:..|.:.::..||||
Human   245 DRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPA 309

  Fly   323 SEFDAMKTNWYRYYWHSIKQTFGFGTSI 350
            .|.:..:..|.|||:..||||||:|..:
Human   310 PEEERTRQGWQRYYFEGIKQTFGYGARL 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1416	NP_610121.2	COG5580	19..347	CDD:227867	131/330 (40%)
		Aha1_N	30..159	CDD:286332	53/129 (41%)
		SRPBCC_Aha1	221..346	CDD:176901	51/124 (41%)
AHSA1	NP_036243.1	Aha1_N	29..158	CDD:214964	56/132 (42%)
AHSA1	NP_036243.1	SRPBCC_Aha1	208..333	CDD:176901	51/124 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142945
Domainoid	1	1.000	109	1.000	Domainoid score	I6377
eggNOG	1	0.900	-	-		E1_COG5580
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8106
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2870
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54070
OrthoDB	1	1.010	-	-		D1548191at2759
OrthoFinder	1	1.000	-	-		FOG0002242
OrthoInspector	1	1.000	-	-		oto91488
orthoMCL	1	0.900	-	-		OOG6_102661
Panther	1	1.100	-	-	LDO	PTHR13009
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1975
SonicParanoid	1	1.000	-	-		X1482
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800