Protein Alignment step and Arfgef2

DIOPT Version :10

• Sequence 1: NP_001036375.2
• Gene: step / 35425
• FlyBaseID: FBgn0086779
• Length: 727
• Species: Drosophila melanogaster
• Sequence 2: NP_001078964.1
• Gene: Arfgef2 / 99371
• MGIID: 2139354
• Length: 1792
• Species: Mus musculus
• Alignment Length: 259
• Identity: 103/259 - (39%)
• Similarity: 145/259 - (55%)
• Gaps: 23/259 - (8%)

  Fly   351 YINTEQSDNLVILRRPSKQIKD-------ELCEVVS---------EMEALDVPEDCKHSNKDKQ- 398
            |:|......|...|.|.:::.|       ..|.|.|         :....|.||..:...:.|:
Mouse   589 YVNPNHQATLGQERLPDQEMGDGKGLDMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEI 653

  Fly   399 MSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAF 463
            :..|.:.||..||:||::|.|..:|....:|:|.||::.|.|:.|.:|::||:...||::|:.|:
Mouse   654 IEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAY 718

  Fly   464 VALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRY--CQLNPDIFTNTDTCYVLSFAI 526
            |...||.....|.|||.||..||||||||||||:||.||.||  |.....:|.:.||.|||:::|
Mouse   719 VDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSI 783

  Fly   527 IMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHT 590
            |||.|.||:|.||:|.|.:|:|.||||||:..|||...|.|:|:.|  |..||...:..:  ||
Mouse   784 IMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEI--EGKKIAMKETKE--HT 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	395..577	CDD:460178	87/184 (47%)
		PH_GRP1-like	592..710	CDD:269954
Arfgef2	NP_001078964.1	DCB, DCB:DCB domain and DCB:HUS domain interaction. /evidence=ECO:0000250	2..224
		PLN03076	11..1718	CDD:215560	103/259 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..294
		HUS, DCB:HUS domain interaction. /evidence=ECO:0000250	515..535