DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and GBF1

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_006718110.1	Gene:	GBF1 / 8729	HGNCID:	4181	Length:	1893	Species:	Homo sapiens

Alignment Length:	374	Identity:	106/374 - (28%)
Similarity:	176/374 - (47%)	Gaps:	83/374 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 SKNSLPPPPY--------IDDMRFIDDSSNSQSESE-RNSNIHKTNKYTSKNNNNDSKRESQQSN 338
            |||:.|....        :|.:..:.||:.:..::: .||...:..|.|::.:
Human   594 SKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPS------------ 646

  Fly   339 LCESCRMLLD--RNYINTEQ--SDNLVI--------------LRRPSKQIKDELCEVVSEMEALD 385
             ||    ::|  |...|||:  ||...:              .|.|.:..|....::   .||:|
Human   647 -CE----IVDGTREASNTERTASDGKAVGMASDIPGLHLPGGGRLPPEHGKSGCSDL---EEAVD 703

  Fly   386 VPEDCKHS--------------------NKDKQMSIGRKKFNMDPKKGIEYLVENRLLR--HDPQ 428
            ...|.|.:                    ||.|.:..|.::||..|||||::|.|..||.  .|..
Human   704 SGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNT 768

  Fly   429 DVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQK 493
            :||.:|.:...|:|..||:::.::.  |.|:|::||:...|..|.|.:|||.:|.:|||||||..
Human   769 EVAQWLRENPRLDKKMIGEFVSDRK--NIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPV 831

  Fly   494 IDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVKDK---PTVDQFISMNRGIN 555
            |.|::|.|.:|:...|...|.|:|.|:.|::|:|||||..||.:|:.:   .|:::|....:|:|
Human   832 IQRLLEAFTERWMNCNGSPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVN 896

  Fly   556 NGGDLPRGLLESLYESIRTEPFKIPQDD---------GNDLMHTFFNPD 595
            .|.|..:.:||.:|.:|:.|...:|::.         .|.|:|....|:
Human   897 GGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWNVLLHRGATPE 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	71/184 (39%)
		PH_GRP1-like	592..710	CDD:269954	1/4 (25%)
		PH	596..708	CDD:278594	106/374 (28%)
GBF1	XP_006718110.1	Sec7_N	434..579	CDD:289549
GBF1	XP_006718110.1	Sec7	733..918	CDD:279680	72/186 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D815698at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820