DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and GEA2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_010892.1	Gene:	GEA2 / 856691	SGDID:	S000000748	Length:	1459	Species:	Saccharomyces cerevisiae

Alignment Length:	378	Identity:	102/378 - (26%)
Similarity:	172/378 - (45%)	Gaps:	81/378 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 LGRMLDVQNEIGTGGLFMEADPCSKNSLPPPPYIDDMRFIDD--SSNSQSESERNSNIHK----- 317
            ||..|.:|.|:....:|         |:          .:||  ::||.||::...:|.|
Yeast   419 LGNNLQLQIELTLTRIF---------SI----------LLDDGTANNSSSENKNKPSIIKELLIE 464

  Fly   318 -------------TNKYTSKNNNNDSKRESQQSNLCES-CRMLLDRNYINTEQSDNLVILRRPSK 368
                         |:.:.:.:.|.|  |.....|..:: .::.|..:.:.|.:|...:.|.....
Yeast   465 QISILWTRSPSFFTSTFINFDCNLD--RADVSINFLKALTKLALPESALTTTESVPPICLEGLVS 527

  Fly   369 QIKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKK------------FNMDPKKGIEYLVENR 421
            .:.|    :...|:.:|..|..:..|   :|.|.:|:            ||..|||||..|:|..
Yeast   528 LVDD----MFDHMKDIDREEFGRQKN---EMEILKKRDRKTEFIECTNAFNEKPKKGIPMLIEKG 585

  Fly   422 LLRHD-PQDVAHFLYKGEG-LNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALRQFLWS 484
            .:..| .:|:|.||:.... :||..||..|...:..:  :|..::.|.||:.|.:.:|:|..|..
Yeast   586 FIASDSDKDIAEFLFNNNNRMNKKTIGLLLCHPDKVS--LLNEYIRLFDFSGLRVDEAIRILLTK 648

  Fly   485 FRLPGEAQKIDRMMETFAQRYCQ------------LNPDIFT---NTDTCYVLSFAIIMLNTSLH 534
            ||||||:|:|:|::|.|:..||:            ...||.|   :.|:.::||::||||||.||
Yeast   649 FRLPGESQQIERIIEAFSSAYCENQDYDPSKISDNAEDDISTVQPDADSVFILSYSIIMLNTDLH 713

  Fly   535 NPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQD-DGND 586
            ||.||:..:.:.:....:|..|..|.|...|:.:|.|||.:...:|:: .||:
Yeast   714 NPQVKEHMSFEDYSGNLKGCCNHKDFPFWYLDRIYCSIRDKEIVMPEEHHGNE 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	70/208 (34%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
GEA2	NP_010892.1	COG5307	298..1331	CDD:227623	102/378 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840