DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and SYT1

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_015420.1	Gene:	SYT1 / 856210	SGDID:	S000006299	Length:	1226	Species:	Saccharomyces cerevisiae

Alignment Length:	804	Identity:	171/804 - (21%)
Similarity:	280/804 - (34%)	Gaps:	251/804 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KKCSPGLGGSESVGRKQPLQRSCLDL---STTRVGCDG---CVSLEFFQSESPESRRSNSTFYVN 83
            |:|.|....|:....::.:.|  |||   |....|.:.   .|:......:.||...     :.:
Yeast    68 KECEPTKKHSKLSRIRRKMGR--LDLNFRSANEKGSEDDEILVAQHLRNGQDPEEMP-----FKS 125

  Fly    84 TQNVSS--AVFKDNRQPLLERGSGSDS-------------------SPSSVCVRCSCNSITKSGD 127
            ..|:.|  .|.|.:.:.:....||||:                   .|||       |.:::...
Yeast   126 ENNIDSIEKVPKPDGERVTLTSSGSDNVKRNSKHAPFIPVKPALEKFPSS-------NRLSRDYR 183

  Fly   128 RNETPTMATPKSDIKIALKPPPKPRSPSMAPYTSVAT---YNITKLAPDSPPPASPTLSTQTVNC 189
            :::.||:.  ..|..:...|.....|.|.:..:|.|.   :|.:|.|    ..||.:.|:.::
Yeast   184 KSQEPTLF--NGDRLVPTLPTVSRISTSSSVGSSTAASRYFNPSKRA----VVASSSSSSSSI-- 240

  Fly   190 SDVTTKVTEVQRLPCD-EPNTEL------ISKRTEYKHTTITTTTRTLIVSRPVELL--LNENGE 245
                 |...:..:|.| .|..||      ||||...:..           ||.|::.  :|:|.
Yeast   241 -----KFNSLHAIPLDATPQIELAKQQDEISKRRFGRRR-----------SRTVDVFDYINKNN- 288

  Fly   246 IIARRSPRKSRSNSLGRMLDVQNEIGTGGLFMEADPC-SKNSLPPPPYIDDMRFIDDSSN----- 304
             .|:..|..|.|:.: |.:|.:|   |..|..  ||. |:..|.|    ||...|.:.::
Yeast   289 -TAKNKPPLSPSSFI-RTIDEKN---TNSLMQ--DPMGSRGPLLP----DDANIISNDTDGAEAS 342

  Fly   305 -------SQSESERNSNIH-------------------------KTNKYTSKNNNND-----SKR 332
                   |:|.|:..|.:.                         .|:.|.:|:|.|.     |:|
Yeast   343 HPDHQVLSRSRSQSTSFVQGKGGKRKSIEDEGYHNKLGLPHGSGPTSVYNNKSNANSTITGMSRR 407

  Fly   333 ESQQSNLCESCRMLLDRNYINTEQSDNLVILR----RPSKQIKDELCEVVSEMEALDVPE---DC 390
            .|...|...|        ::|. :|.:|...|    :..:|::.:|...:.::..:..||   .|
Yeast   408 SSSIVNALSS--------FVNL-RSSSLSSSRQQHLQQQQQLQQKLDVSLEDLPPVPAPEFSDSC 463

  Fly   391 KHSNKDKQMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKND- 454
            |                                        .||.|.....| .||..|.||:|
Yeast   464 K----------------------------------------DFLIKLAPYGK-FIGIILTEKDDE 487

  Fly   455 FNEDVLKAFVA-LHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDI------ 512
            |.::.|...:. ..:|.|..|..|||:.|....||.|.|:|||::..|:..|.:.....
Yeast   488 FKKNCLNYLLTNCFEFKNDPLDIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSKKKGI 552

  Fly   513 ---FTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTVDQFISM--NRGINNGGDLPRGLLESLYESI 572
               ::|.|..|.::|:::||:|...||:.|.|.|...|:.:  |...:.|.::|..:|...||::
Yeast   553 ECPWSNADQVYFIAFSLLMLHTDYFNPNNKSKMTKHDFVDLVHNDKYSGGNEIPMAVLTYFYENV 617

  Fly   573 RTE-----------PFKIPQDDG---NDLMHTFFNPDKEGWLWKQGGRYKSWKRRWFILNDNCLY 623
            ..:           |..:  ||.   .|...|.|.                     ..|:.|.:|
Yeast   618 TAKESPKFNYFLMSPMAL--DDSILDKDAFDTNFA---------------------ITLSSNSMY 659

  Fly   624 YFEYTTDKEPRG-IIPLENISVREIHDRSKPHCFELFATGGADIIKACKTDSEGKVVEGKHTVYR 687
               ...|...|| |||.| .|:..|.   .|....:.|:|.|....|....|....:.|.:
Yeast   660 ---SPIDMIKRGSIIPKE-ASLSPIF---YPLTNSISASGIAPSTAASCPPSTSGTINGAN---- 713

  Fly   688 MSAATEEDQQEWIKRLTQSISHNP 711
            :..|.....:.....::...|:||
Yeast   714 LGTANSNSNRPASNSISSYFSYNP 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	47/203 (23%)
		PH_GRP1-like	592..710	CDD:269954	22/118 (19%)
		PH	596..708	CDD:278594	20/112 (18%)
SYT1	NP_015420.1	COG5307	141..1221	CDD:227623	154/724 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000