DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and GEA1

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_012565.1	Gene:	GEA1 / 853488	SGDID:	S000003792	Length:	1408	Species:	Saccharomyces cerevisiae

Alignment Length:	769	Identity:	163/769 - (21%)
Similarity:	271/769 - (35%)	Gaps:	237/769 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 SCNSITKSGDRNET------PTMA--TPKSDIKIALKPPPKPRSPSMAPYTSVATYNITKLAPDS 174
            :||:     .|:|.      .|:|  |.|...|:.|..||    .....|.:..:|....|..|.
Yeast   204 ACNT-----QRSEVLRKTAEVTIAGITVKLFTKLKLLDPP----TKTEKYINDESYTDNNLKDDI 259

  Fly   175 PPPASPTLSTQTVNCSDVTTKVTE-------VQRLPCDEPNTE---------------------- 210
               ...|.|...::.:|..:.|.:       ||::..::.|.|
Yeast   260 ---IGTTTSDNDLSSTDDDSAVADDNKNEKPVQQVIREQENDEETAEKAENVEPNYGITVIKDYL 321

  Fly   211 -----LISKRTEYKHTTITTTTRTLIVSRPVELLLNENGE---------------------IIAR 249
                 |:......||||........:::..:|:    :|:                     .|.:
Yeast   322 GLLLSLVMPENRMKHTTSAMKLSLQLINAAIEI----SGDKFPLYPRLFSLISDPIFKSVLFIIQ 382

  Fly   250 RSPRKSRSNS-----------LGRMLDVQNEIGTGGLF--MEADPCSKN-SLPPPPYIDDM---- 296
            .|.:.|...:           ||..|.:|.|:....:|  :|....|.: |...||.|.::
Yeast   383 SSTQYSLLQATLQLFTSLVVILGDYLPMQIELTLRRIFEILEDTTISGDVSKQKPPAIRELIIEQ 447

  Fly   297 --------------RFIDDSSNSQSESERNSNIHKTNKYT----SKNNNNDSKRESQQSNLC-ES 342
                          .|::...|..........|.:..|::    :.|.:|:.      ..:| |.
Yeast   448 LSILWIHSPAFFLQLFVNFDCNLDRSDLSIDFIKELTKFSLPAAAVNTSNNI------PPICLEG 506

  Fly   343 CRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQMSIGRKKFN 407
            ...|::..|.:.::.|.               .|.|...:.:|:   .|..::..:..:..:.||
Yeast   507 VLSLIENIYNDLQRFDR---------------AEFVKNQKEIDI---LKQRDRKTEFILCVETFN 553

  Fly   408 MDPKKGIEYLVENRLLRHDP-QDVAHFLYKGEG-LNKTAIGDYLGEKNDFNEDVLKAFVALHDFT 470
            ...||||:.|:|...:..|. :|:|.||:...| |||..||..|.:..  ...:||.|:.|.||.
Yeast   554 EKAKKGIQMLIEKGFIDSDSNRDIASFLFLNNGRLNKKTIGLLLCDPK--KTSLLKEFIDLFDFK 616

  Fly   471 NLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRY-----------------------------C 506
            .|.:.:|:|..|..||||||:|:|:|::|.|:.:|                             .
Yeast   617 GLRVDEAIRILLTKFRLPGESQQIERIVEAFSSKYSADQSNDKVELEDKKAGKNGSESMTEDDII 681

  Fly   507 QLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYES 571
            .:.||    .|:.:|||::||||||..|||.|||..|.|.:.:..||..||.|.||..|..:|.|
Yeast   682 HVQPD----ADSVFVLSYSIIMLNTDSHNPQVKDHMTFDDYSNNLRGCYNGKDFPRWYLHKIYTS 742

  Fly   572 IRTEPFKIPQD-DGNDLMHTFFNPDKEGWLWKQGGRYKSWKRRWFILND---NCLYYFEYTTDKE 632
            |:.:...:|:: .||:                          |||  .|   |.:......|:.:
Yeast   743 IKVKEIVMPEEHHGNE--------------------------RWF--EDAWNNLISSTSVMTEMQ 779

  Fly   633 PRGIIPLENI--------------SVREIHDRSKPHCFELFATGGADIIKACKTDSEGKVV---- 679
            .....|:..:              :||:|..::   .|::|....:|.|.....|:..|..
Yeast   780 RDFTNPISKLAQIDILQYEKAIFSNVRDIILKT---LFKIFTVASSDQISLRILDAISKCTFINY 841

  Fly   680 ------EGKHTVYRMSAATEEDQQEWIKRLTQSISHNPFYDILVQRKKKALSKS 727
                  ....||..:...|...|.. .|.:...:...|..:|.|:.....:|.|
Yeast   842 YFSFDQSYNDTVLHLGEMTTLAQSS-AKAVELDVDSIPLVEIFVEDTGSKISVS 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	73/210 (35%)
		PH_GRP1-like	592..710	CDD:269954	21/144 (15%)
		PH	596..708	CDD:278594	21/138 (15%)
GEA1	NP_012565.1	COG5307	283..1325	CDD:227623	143/678 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840