DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and Plekha2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_112547.1	Gene:	Plekha2 / 83436	MGIID:	1928144	Length:	425	Species:	Mus musculus

Alignment Length:	191	Identity:	51/191 - (26%)
Similarity:	82/191 - (42%)	Gaps:	37/191 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   536 PSVKDKPTVDQFISMNRGI-------NNGGDLPRGLLESLYESIRTEPFKIP-----QDDGNDLM 588
            |:::.||.|.....:..|:       .||||...|.....:..:|.....||     ...|..|:
Mouse   136 PTLEKKPQVAYKTEIIGGVVVQTPISQNGGDGQEGCEPGTHAFLRRSQSYIPTSGCRPSTGPPLI 200

  Fly   589 HTFFNPDKEGWLWKQGGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKP 653
                   |.|:..|||...||||||:|.|:|..:.||:...|:||...|||:::        .|.
Mouse   201 -------KSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDREPLRTIPLKDV--------LKT 250

  Fly   654 HCFELFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRL---TQSISHNP 711
            |  |.....|..:::    |:..:::....|.| :.|.:.||...||:.:   .|::..:|
Mouse   251 H--ECLVKSGDLLMR----DNLFEIITTSRTFY-VQADSPEDMHSWIEGIGAAVQALKCHP 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	11/47 (23%)
		PH_GRP1-like	592..710	CDD:269954	35/120 (29%)
		PH	596..708	CDD:278594	35/114 (31%)
Plekha2	NP_112547.1	PH1_TAPP1_2	1..119	CDD:270089
		PH2_TAPP1_2	192..306	CDD:270090	38/135 (28%)
		PHA03247	<304..410	CDD:223021	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910