DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and iqsec2b

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_005167294.1	Gene:	iqsec2b / 797187	ZFINID:	ZDB-GENE-081105-73	Length:	1581	Species:	Danio rerio

Alignment Length:	945	Identity:	201/945 - (21%)
Similarity:	328/945 - (34%)	Gaps:	350/945 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PSISNWFSSLRRQP-----------KNKKCSPGLGGSESVGRKQPLQRSCLDLSTTRVGCDGCVS 62
            |:...|....|.||           :||:|.   ..|:|......||...:::...:.|
Zfish   196 PASLAWAQRTRNQPASLALRKQEEEENKRCK---ALSDSYELSTDLQDKKVEMLEKKYG------ 251

  Fly    63 LEFFQSESPESRRSNSTFYVNTQNVSSAVFKDNRQPLLERGSGSDSSPSSVCVRCSCNSITKSGD 127
             .:|     .|||:     ..|...:...::.|:.....|.|.|:|..:...:..:........|
Zfish   252 -GYF-----VSRRA-----ARTIQTAFRQYRMNKNFERLRSSASESRMTRRIILSNMRLQYSFDD 305

  Fly   128 RNETPTMATPKSDIKIALKPPPKPRSPSMAPYTSVATYNITKLAPDSPPPASPTLSTQTVNCSDV 192
            |:                   |:|.:|:...:           :|...||.|||.:|
Zfish   306 RH-------------------PQPPNPTHYSH-----------SPGMGPPHSPTSTT-------- 332

  Fly   193 TTKVTEVQRLPCDEPNTELISKRTEYK--HTTITTTTRTL-------IVSRP-----------VE 237
                         ||:    |.|.||.  ..|.:...::|       :..||           |.
Zfish   333 -------------EPS----SPRPEYTQLEDTFSKQVKSLADSIDDALTCRPRRDDSQEGIGDVS 380

  Fly   238 LLLNENGEIIARRSPRKSRSN-SLGRMLDVQNEIGTGGLFMEAD-----------------PCSK 284
            .::::.||.|     ..|.|: ||.|.|..::..|||||.|..|                 |.|.
Zfish   381 GVVDDFGECI-----WSSNSHASLRRGLADRDRGGTGGLSMHEDSTATSYSDVTLYMDDGLPSSP 440

  Fly   285 NSLPPPPYIDDMRF----------IDDSSNSQ----SESERNSNIHKTNKY-------------- 321
            .||...|...|..|          .:||.:::    |.|.|::...:...|
Zfish   441 LSLDRAPSSTDTEFWGGVGSGVGGREDSRDTEGGGSSNSRRSTPCTECRDYRLRGGHLPLLTIEP 505

  Fly   322 ----------------------------------TSKNNNN------------------------ 328
                                              |.|:|.|
Zfish   506 PSDSSVDMSDRSDRGSLSRQLVYEQDSAGGSPQGTLKHNPNARSQSSTTAQGQTRPASRSIPSHI 570

  Fly   329 -----------------------DSKRESQQ----------------SNLCESCRMLLDRNYINT 354
                                   .|....||                ..|.:.|....|.:.:|:
Zfish   571 PHHMAHHHHHHHHHHHHQYPDTPSSSSSPQQPPTTPLSSSSSAPLPPGGLEQQCCSDGDNDSLNS 635

  Fly   355 EQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHS------NKD----KQMSIGRKKFNMD 409
            ..:.|..|........:|.|.|.:..:.......:.:|:      |.|    :|..||...||..
Zfish   636 TTNSNETINCSSGSSSRDSLREPLPPLGKQTYQRESRHNWDSPAFNNDVVQRRQYRIGLNLFNKK 700

  Fly   410 PKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEK-NDFNEDVLKAFVALHDFTNLI 473
            |:|||:||:|...:...|..:|.|:.:.:||::..||::||.: ..||:|||...|...||:.:.
Zfish   701 PEKGIQYLIEKGFVSDTPVGIARFILERKGLSRQMIGEFLGNRQKQFNKDVLDCVVDEMDFSGMD 765

  Fly   474 LVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDI---FTNTDTCYVLSFAIIMLNTSLHN 535
            |..|||:|....::.|||||::|::|.|:||||..||.:   |.|.||.::|:||||:|||.:::
Zfish   766 LDDALRKFQAQIKVQGEAQKVERLIEAFSQRYCVCNPALVRQFQNPDTIFILAFAIILLNTDMYS 830

  Fly   536 PSVK--DKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDL----------- 587
            |::|  .|..:|.||...||::||.::||.||..:|:.|:....:...|..:.:
Zfish   831 PNIKAERKMKLDDFIKNLRGVDNGQEIPRDLLVGIYQRIQKWELRTNDDHVSQVQAVERVIVGKK 895

  Fly   588 ---------------MHTFFNPDKEGWLWKQGGRYKSWKRRWFILND-------------NCLYY 624
                           :|...:|::.    ::.|.:   :|..|:.||             :..|.
Zfish   896 PVLSLPHRRLVCCCQLHEVPDPNRP----QRSGVH---QREVFLFNDLLVVTKIFQKKKTSVTYS 953

  Fly   625 FEYTTDKEPRGIIPLENISVREIHDRSKPHCFELFAT--GGADIIKACKTDSEGKVVEGKHTVYR 687
            |        |...||..:.|....:...||...|.:.  ||           |.||:    .|:
Zfish   954 F--------RQSFPLVEMQVHMFQNSYYPHGVRLTSAIPGG-----------ERKVL----IVF- 994

  Fly   688 MSAATEEDQQEWIKRLTQSISHNPFYDILVQRKKK 722
             :|.:::|:..::..|.:||:.       ||..:|
Zfish   995 -TAPSQQDRTRFVSDLRESIAE-------VQEMEK 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	76/185 (41%)
		PH_GRP1-like	592..710	CDD:269954	26/132 (20%)
		PH	596..708	CDD:278594	24/126 (19%)
iqsec2b	XP_005167294.1	Sec7	686..871	CDD:279680	76/184 (41%)
		IQ_SEC7_PH	899..1026	CDD:293062	30/162 (19%)
		PH	926..1014	CDD:278594	23/115 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910