DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment step and Pdzph1

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_081277.1	Gene:	Pdzph1 / 69239	MGIID:	1916489	Length:	1238	Species:	Mus musculus

Alignment Length:	815	Identity:	160/815 - (19%)
Similarity:	277/815 - (33%)	Gaps:	234/815 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QKRPSISNWFSSLRRQPKNKKCSPGLGG-----------SESVGRK-QPLQRSCLDLSTTRVGCD 58
            ::|.:.|:...::....:.:.|:.|..|           .::.|.: .||....|.|...:....
Mouse   401 EERKNSSDVRENITPDSQVQPCTAGTNGPLSAVNSIIPIQDASGSEFSPLSFLTLQLLGAKADNM 465

  Fly    59 GCVSLEFFQSESPESRRSNSTFYVNTQNVSSAVFKDNRQPLLERGSGSDSSPSSVCVRCSCNSIT 123
            ||...|....|..||  |||..:    .||....|.:  |||        |||....||| ..:.
Mouse   466 GCRGEETLPGEGHES--SNSLLF----PVSEQAAKPS--PLL--------SPSHRVSRCS-EPVE 513

  Fly   124 KSGDR---------------------NETPTMATPKSDIKIALKPPPKPRSPSMAPYTSVATYNI 167
            .:|:.                     |:........|:|:      |..|....:|..::|:.:|
Mouse   514 TTGNTFSFSQYIGVEREQEKVHYRLINKASLHNDSSSNIQ------PLERKDPQSPAVTIASCSI 572

  Fly   168 TKLAPDSPPPASPTLSTQTVNCSDVTTKVTEVQRLPCDEPNTELISKRTE-------YKHTTITT 225
              |.|.||...:...|.:.....|.............:.|....|:...|       ||.:|:
Mouse   573 --LVPKSPLHGNIHSSVEWNQTEDHANHAERAGLSRMEVPVMASITNELEQSLATQNYKESTV-- 633

  Fly   226 TTRTLIVSRPVELLLNENGEIIARRSPRKSRS------NSLGRMLDV----------------QN 268
                            ::...:|.|:||:|.|      :...:.|.|                ||
Mouse   634 ----------------DSNSPMAIRNPRESTSYLENVGDDASQALPVVKNMCHRNFEDLTRENQN 682

  Fly   269 EIGTGGLFMEADPCSKNSLPPPPYIDDMRFIDDSSNSQS---------------ESERNSNIHKT 318
            ||           ||:           |.|:.:||.|.|               .|:.:||.::.
Mouse   683 EI-----------CSQ-----------MDFLQNSSESTSVGHTTEKLFLIDKTLASDDDSNSNRD 725

  Fly   319 NKYTSKNNNNDSKRESQQSNLCESCRMLLDRNYINTEQSDNLV-ILRRPSKQ--IKDELCEV--- 377
            :|....||......|.|::.....|....::.| .||.|.:.| ||..|.||  :||:..|:
Mouse   726 HKTCGLNNFQQEPAECQRTTSRVYCEESGNQRY-PTEVSCHPVDILLSPQKQKALKDQNLEINNP 789

  Fly   378 ----------------VSEMEALDVPEDCKHSNKDKQMSIGRKKFNMDPKKGIEYLVENRLLRHD 426
                            .|:.||::     :.:.:.:|...|::..:......|....|..:...|
Mouse   790 RKLSQELALRGGRASDGSQEEAIE-----QWARRRQQFKDGKRCSSAGGSSVISNFTEGSITSDD 849

  Fly   427 PQ--------DVAHFLYKGEGLNKTAIGDYLGEKNDFN-EDVLKAF------VALHDFTNLILVQ 476
            ..        |:....:..|..:.||   ::...:|.| ||..:..      ||:.:.| :.|.:
Mouse   850 VHSVDFGFRVDIEEKGFYTENFHSTA---WVFRGDDGNPEDSPRCLSKKPRPVAVRERT-VRLFK 910

  Fly   477 ALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVKDK 541
            ....:.|.||:            .|::      |.:.|..||......|.:.:...:.:.:..:.
Mouse   911 GTGDYPWGFRI------------QFSK------PIVVTEVDTNSAAEEAGLQIGDVVLSVNGTEV 957

  Fly   542 PTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDKEGWLWKQ--G 604
            .:|:...:::        |.:..|:.|...:.::..:.|....         |...|:|.|:  .
Mouse   958 TSVEHAEAVH--------LAKKGLDILTMVVASDISRCPNTPW---------PTCRGYLHKRTHS 1005

  Fly   605 GRYKSWKRRWFIL-NDNCLYYFEYTTDK---EPRGIIPLENISVREIHDRSKPHCFELFATGGAD 665
            |..|.|::|||:| :|..|.|:::..|:   .|..:|.||...|...:...||..|......|:.
Mouse  1006 GFVKGWRKRWFVLKHDGFLLYYKHRKDEGKWPPLDMIKLEGAEVDIDNSLGKPFVFNCMPQSGSR 1070

  Fly   666 IIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWI 700
            |:..|.|.::    |.|..:..|..|.....|..:
Mouse  1071 ILCLCATSNQ----EMKRWLEAMQRAARPVHQNHV 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	30/194 (15%)
		PH_GRP1-like	592..710	CDD:269954	32/115 (28%)
		PH	596..708	CDD:278594	31/111 (28%)
Pdzph1	NP_081277.1	PDZ_signaling	903..981	CDD:238492	15/104 (14%)
		PH-like	986..1093	CDD:302622	31/119 (26%)
		PH	993..1094	CDD:278594	31/104 (30%)
		PH-like	1123..1215	CDD:302622
		PH	1125..1216	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910