DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and Plekha4

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_006541221.1	Gene:	Plekha4 / 69217	MGIID:	1916467	Length:	831	Species:	Mus musculus

Alignment Length:	188	Identity:	43/188 - (22%)
Similarity:	66/188 - (35%)	Gaps:	74/188 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 TSLHNPSVKDKPT-----VDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHT 590
            :||.:.|.| |||     |..|...|..:....:||                          :|.
Mouse    72 SSLSSLSTK-KPTRAVHKVHAFGKRNNALRRDPNLP--------------------------VHI 109

  Fly   591 FFNPDKEGWLWKQ-GGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKPH 654
                  .|||.|| ....:.||||||:|:.:||:|::.:.::...|.:.|.:.|||
Mouse   110 ------RGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYSVR--------- 159

  Fly   655 CFELFATGGADIIKACKTDSEGKVVEGKHT---------VYRMSAATEEDQQEWIKRL 703
                             .|..|.....:.|         .|.::|.|.||.:.|::.|
Mouse   160 -----------------PDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRAL 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	12/50 (24%)
		PH_GRP1-like	592..710	CDD:269954	30/122 (25%)
		PH	596..708	CDD:278594	30/118 (25%)
Plekha4	XP_006541221.1	PH_PEPP1_2_3	101..204	CDD:270068	33/158 (21%)
		PHA03247	<276..812	CDD:223021
		Smc	<411..>523	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910