DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and PLEKHA2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_067636.1	Gene:	PLEKHA2 / 59339	HGNCID:	14336	Length:	425	Species:	Homo sapiens

Alignment Length:	235	Identity:	59/235 - (25%)
Similarity:	92/235 - (39%)	Gaps:	66/235 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   536 PSVKDKPTVDQFISMNRGI-------NNGGDLPRGLLESLYESIRTEPFKIP-----QDDGNDLM 588
            |:::.||.|.....:..|:       .||||...|.....:..:|.....||     ...|..|:
Human   136 PALEKKPQVAYKTEIIGGVVVHTPISQNGGDGQEGSEPGSHTILRRSQSYIPTSGCRASTGPPLI 200

  Fly   589 HTFFNPDKEGWLWKQGGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKP 653
                   |.|:..|||...||||||:|.|:|..:.||:...|:|     ||..|.::::   .|.
Human   201 -------KSGYCVKQGNVRKSWKRRFFALDDFTICYFKCEQDRE-----PLRTIFLKDV---LKT 250

  Fly   654 HCFELFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRL--------------- 703
            |  |.....|..:::    |:..:::....|.| :.|.:.||...|||.:
Human   251 H--ECLVKSGDLLMR----DNLFEIITSSRTFY-VQADSPEDMHSWIKEIGAAVQALKCHPRETS 308

  Fly   704 -----------TQSISHNPFYDILVQ-----RKKKALSKS 727
                       :.|:|..| ..||.:     .:||||.|:
Human   309 FSRSISLTRPGSSSLSSGP-NSILCRGRPPLEEKKALCKA 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	11/47 (23%)
		PH_GRP1-like	592..710	CDD:269954	36/143 (25%)
		PH	596..708	CDD:278594	35/137 (26%)
PLEKHA2	NP_067636.1	PH1_TAPP1_2	1..119	CDD:270089
		PH	10..113	CDD:278594
		PH2_TAPP1_2	192..307	CDD:270090	36/136 (26%)
		PH	199..297	CDD:278594	35/119 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..332		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910