DRSC/TRiP Functional Genomics Resources

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Protein Alignment step and RASGRF1

DIOPT Version :9

Sequence 1:NP_001036375.2 Gene:step / 35425 FlyBaseID:FBgn0086779 Length:727 Species:Drosophila melanogaster
Sequence 2:NP_002882.3 Gene:RASGRF1 / 5923 HGNCID:9875 Length:1273 Species:Homo sapiens


Alignment Length:236 Identity:51/236 - (21%)
Similarity:80/236 - (33%) Gaps:85/236 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   550 MNRGI--NNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPDKEGWLWKQGGRYKSWKR 612
            |.:||  |:|.....|||              .:.||.          ::|:|.|:......|:.
Human     1 MQKGIRLNDGHVASLGLL--------------ARKDGT----------RKGYLSKRSSDNTKWQT 41

  Fly   613 RWFILNDNCLYYFEYTTDKEPRGIIPLEN------------ISVRE------------IHDRSK- 652
            :||.|..|.|:|||..:...|.|:..||.            :|.:|            .|:..| 
Human    42 KWFALLQNLLFYFESDSSSRPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKA 106

  Fly   653 --------PHCFELFATGGADIIKACKTDSEG---------KVVEGKHTVYRMSAATEEDQQEWI 700
                    ..|.|..|.......:...|:.|.         ::||.:.||.:......||.:..|
Human   107 LELRTEDAKDCDEWVAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEI 171

  Fly   701 KRL----------------TQSISHNPFYDILVQRKKKALS 725
            :||                ||:::.|. .|..:::.||..|
Human   172 ERLKAEITSLLKDNERIQSTQTVAPND-EDSDIKKIKKVQS 211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stepNP_001036375.2 Sec7 397..577 CDD:279680 8/28 (29%)
PH_GRP1-like 592..710 CDD:269954 36/175 (21%)
PH 596..708 CDD:278594 36/169 (21%)
RASGRF1NP_002882.3 PH 489..583 CDD:278594
RasGEF_N 647..>695 CDD:279012
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..754
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..874
REM <938..1007 CDD:295342
RasGEF 1034..1270 CDD:214539
PH_RasGRF1_2 19..154 CDD:270081 29/144 (20%)
PH 24..129 CDD:278594 23/114 (20%)
RhoGEF 244..425 CDD:214619
PH-like 431..582 CDD:302622
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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