Protein Alignment step and RASA1

DIOPT Version :9

• Sequence 1: NP_001036375.2
• Gene: step / 35425
• FlyBaseID: FBgn0086779
• Length: 727
• Species: Drosophila melanogaster
• Sequence 2: NP_002881.1
• Gene: RASA1 / 5921
• HGNCID: 9871
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 112/515 - (21%)
• Similarity: 184/515 - (35%)
• Gaps: 151/515 - (29%)

  Fly   270 IGTGGLFMEADPCSKNSLPPPPY----------IDDMRFIDDSSNSQSESERNSNIHKTNK-YTS 323
            :|.||.|        ..||||||          :|:...:|.....:.|.........||: |..
Human   128 LGPGGGF--------PPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHG 184

  Fly   324 KNNNNDSKRESQQSN------LCESCR--------MLLDRNYIN----TEQSDNLVILRRPSKQI 370
            |.:...::...:|:.      :.||.|        .|...|.:|    .....:..|..|....:
Human   185 KLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSL 249

  Fly   371 KDEL-------CEVVSEMEALDV--PEDCKHSNKDKQMSIGRKKFNMDP---KKGIEYLVENRL- 422
            .|.:       |.:..|.....|  ||..:...:.:.:....|..:.|.   .||..::|.|.|
Human   250 SDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELE 314

  Fly   423 --------LRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVALHDFTNLILVQALR 479
                    ||.|.|          ||....:.:.:|.:.|.:|..
Human   315 DGWMWVTNLRTDEQ----------GLIVEDLVEEVGREEDPHEGK-------------------- 349

  Fly   480 QFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLNTSLHNPSVKDKPTV 544
              :| |......|:...::.|..| .|........||...|.|.|   ..|.::....:...|.
Human   350 --IW-FHGKISKQEAYNLLMTVGQ-VCSFLVRPSDNTPGDYSLYF---RTNENIQRFKICPTPN- 406

  Fly   545 DQFISMNRGINNGGDL-----PRGLLESLYESIRTEPFKIP-QD---------DGNDLMHT---- 590
            :||:...|..|:.||:     ...::|..|   ..||  :| ||         ||.::.:|
Human   407 NQFMMGGRYYNSIGDIIDHYRKEQIVEGYY---LKEP--VPMQDQEQVLNDTVDGKEIYNTIRRK 466

  Fly   591 -----FFNPDKEGWLWKQGGRYKSWKRRWFIL--NDNCLYYFEYTTDK---EPRGIIPLENISVR 645
                 :.|..|:|:|.|: |:.|.||..:|||  :|..|.|||  ::|   :|:|:|.|...||.
Human   467 TKDAFYKNIVKKGYLLKK-GKGKRWKNLYFILEGSDAQLIYFE--SEKRATKPKGLIDLSVCSVY 528

  Fly   646 EIHDR--SKPHCFELFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRL 703
            .:||.  .:|:||::.....::                :|.::..:..|.|..::|:|.|
Human   529 VVHDSLFGRPNCFQIVVQHFSE----------------EHYIFYFAGETPEQAEDWMKGL 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	38/196 (19%)
		PH_GRP1-like	592..710	CDD:269954	35/119 (29%)
		PH	596..708	CDD:278594	34/115 (30%)
RASA1	NP_002881.1	SH2_Nterm_RasGAP	161..264	CDD:198216	16/102 (16%)
		SH3_RasGAP	281..339	CDD:212722	13/67 (19%)
		SH2_Cterm_RasGAP	350..426	CDD:198217	19/81 (23%)
		PH_RASA1	489..576	CDD:270080	28/102 (27%)
		C2_Ras_p21A1	591..716	CDD:176045
		RasGAP_p120GAP	714..1045	CDD:213340

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910