DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and PTPN11

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	NP_001317366.1	Gene:	PTPN11 / 5781	HGNCID:	9644	Length:	597	Species:	Homo sapiens

Alignment Length:	425	Identity:	81/425 - (19%)
Similarity:	142/425 - (33%)	Gaps:	133/425 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 PASPTLSTQTVN----CSDVTTKVTEV----QRLPCDEPNTELISKRTE----YKHTTITTTTRT 229
            |....||.:|.:    .:|..:|||.|    |.|..|....|.....|:    ||...:..|..|
Human   144 PGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGT 208

  Fly   230 LI-VSRPVELLLNENGEIIARRSPRKSRSNSLGRMLDVQNEIGTGGLF------MEADPCS---- 283
            :: :.:|:........||       :||...|.::.:..:::..|  |      ::...|.
Human   209 VLQLKQPLNTTRINAAEI-------ESRVRELSKLAETTDKVKQG--FWEEFETLQQQECKLLYS 264

  Fly   284 ---------------KNSLPPPPYIDDMRFI--DDSSNSQSESERNSNIHKTNKYTSKNNNNDSK 331
                           ||.||    .|..|.:  |...|.......|:||... ::.:|.||:..|
Human   265 RKEGQRQENKNKNRYKNILP----FDHTRVVLHDGDPNEPVSDYINANIIMP-EFETKCNNSKPK 324

  Fly   332 RE------SQQSNLCESCRMLLDRN----YINTEQSDNLVILRRPSKQIK---DELC-EVVSEME 382
            :.      ..|:.:.:..||:...|    .:.|::     :.|..||.:|   ||.. :....|.
Human   325 KSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKE-----VERGKSKCVKYWPDEYALKEYGVMR 384

  Fly   383 ALDVPEDCKHSNKDKQMSIGR----------------KKFNMDPKKGIEYLVENRLLRHDPQDVA 431
            ..:|.|...|....:::.:.:                ..|...|..|:.         .||..|.
Human   385 VRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVP---------SDPGGVL 440

  Fly   432 HFL----YKGE--------------GLNKTA-------IGDYLGEKN-DFNEDVLKAF-VALHDF 469
            .||    :|.|              |:.:|.       :.|.:.||. |.:.||.|.. :.....
Human   441 DFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQR 505

  Fly   470 TNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQR 504
            :.::..:|..:|::        ..:...:||..:|
Human   506 SGMVQTEAQYRFIY--------MAVQHYIETLQRR 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	24/151 (16%)
		PH_GRP1-like	592..710	CDD:269954
		PH	596..708	CDD:278594
PTPN11	NP_001317366.1	SH2_N-SH2_SHP_like	5..103	CDD:198203
		SH2_C-SH2_SHP_like	111..218	CDD:198185	19/73 (26%)
		PTPc-N11	272..528	CDD:350453	51/282 (18%)
		Substrate binding. /evidence=ECO:0000250	463..469		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910