DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and cyth2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_005157903.1	Gene:	cyth2 / 569358	ZFINID:	ZDB-GENE-100921-55	Length:	416	Species:	Danio rerio

Alignment Length:	388	Identity:	254/388 - (65%)
Similarity:	310/388 - (79%)	Gaps:	13/388 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 DRNYI----NTEQSDNLVILRRPS-------KQIKDELCEVVSEMEALDV-PEDCKHSNKDKQMS 400
            |.:||    :.|:...|..:||..       :::|:||.|.:.|:|.|:. .|..|...|.:.::
Zfish    19 DLDYIPADLSPEERSELEEIRRRKGALLLEIQRLKEELREAIIEVEGLETSTEGSKTLQKSRHVA 83

  Fly   401 IGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKAFVA 465
            :|||||||||||||.:||||.||||.|:|:|.|||||||||||||||||||::|||..||:|||.
Zfish    84 MGRKKFNMDPKKGIVFLVENELLRHTPEDIAQFLYKGEGLNKTAIGDYLGERDDFNIKVLQAFVD 148

  Fly   466 LHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSFAIIMLN 530
            ||:||:|.||||||||||||||||||||||||||.||||||..||.:|.:|||||||||||||||
Zfish   149 LHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCHCNPGVFQSTDTCYVLSFAIIMLN 213

  Fly   531 TSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMHTFFNPD 595
            ||||||:|:|||||::|||||||||:|||||..||.:||:||:.||||||:||||||.|||||||
Zfish   214 TSLHNPNVRDKPTVERFISMNRGINDGGDLPEELLRNLYDSIKNEPFKIPEDDGNDLTHTFFNPD 278

  Fly   596 KEGWLWKQGGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKPHCFELFA 660
            :||||.|.|||.|:||||||||.|||||||||||||||||||||||:|:||:.|..||:||||:.
Zfish   279 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYI 343

  Fly   661 TGG-ADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQSISHNPFYDILVQRKKK 722
            ... ..:||||||:::|:||||.|.|||:||.|.|::.|||..:..::|.:|||::|..|||:
Zfish   344 PNNRGQLIKACKTEADGRVVEGNHMVYRISAPTPEEKDEWIHSIKSAVSVDPFYEMLAARKKR 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	139/179 (78%)
		PH_GRP1-like	592..710	CDD:269954	77/118 (65%)
		PH	596..708	CDD:278594	72/112 (64%)
cyth2	XP_005157903.1	Sec7	78..260	CDD:279680	140/181 (77%)
		PH_GRP1-like	275..394	CDD:269954	77/118 (65%)
		PH	279..392	CDD:278594	72/112 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	298	1.000	Domainoid score	I1419
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1168
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000619
OrthoInspector	1	1.000	-	-		otm25514
orthoMCL	1	0.900	-	-		OOG6_103039
Panther	1	1.100	-	-	O	PTHR10663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X419
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.820