DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and acap2a

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_005163306.1	Gene:	acap2a / 564814	ZFINID:	ZDB-GENE-081104-34	Length:	824	Species:	Danio rerio

Alignment Length:	448	Identity:	82/448 - (18%)
Similarity:	155/448 - (34%)	Gaps:	128/448 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 DDMRF---IDDSSNSQSESERNSNIHKTNK-----------YTSKNNN----------NDSKRES 334
            |..||   |:|......|.|  |.:.|..|           |...|..          ..::.|.
Zfish    13 DSPRFRATIEDVEEDFGELE--SKLDKLVKLCIGMIDAGRVYNQANKQFVNGIRDLALQSTRDEV 75

  Fly   335 QQSNLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSNKDKQM 399
            ..|:|......|.:.|..:|      ::..:..:.|:.:|...|.|    |:          ::.
Zfish    76 IGSSLAAFSETLQEMNNYHT------ILFDQAQRSIRSQLQTFVKE----DL----------RKF 120

  Fly   400 SIGRKKFNMDPKKGIEYLVEN----RLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNE--- 457
            ...:|:|:...::....||:|    |...|:.::..:.|...:...:....||:.:.|....
Zfish   121 KDAKKQFDKVSEEKEVALVKNAQVPRNKLHEVEEATNILTTTQKFFRNIALDYVLQINVLQSKRR 185

  Fly   458 -DVLKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYV 521
             ::||:.:|..:.......|....|          .::..:|:..:.:..||            |
Zfish   186 LEILKSMLAYMNANLTFFNQGHDLF----------SQLQPLMKQLSGQLDQL------------V 228

  Fly   522 LSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGND 586
            :..|....:....:.|::.|..:..|.:                    |..:.| :.|..|:|..
Zfish   229 VDSAKEKRDMEQKHSSIQQKAALQDFST--------------------EDSKLE-YNIDTDNGIA 272

  Fly   587 LMHTFFNPDKEGWLWKQGGR-YKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDR 650
            :         ||:|:|:... :|:|.||||.:.::.|.|.:...|.....:..|...:|:...|.
Zfish   273 M---------EGYLFKRASNAFKTWNRRWFSIQNSQLVYQKRFRDNPTVVVEDLRLCTVKHCEDV 328

  Fly   651 SKPHCFELFATGGADIIKACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKRLTQSIS 708
            .:..|||:.:..     |:|                .|.|.:|:.:|.|||.:..||:
Zfish   329 ERRFCFEVLSPS-----KSC----------------MMQADSEKLRQAWIKAVQSSIA 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	26/187 (14%)
		PH_GRP1-like	592..710	CDD:269954	30/118 (25%)
		PH	596..708	CDD:278594	29/112 (26%)
acap2a	XP_005163306.1	BAR_ACAP2	18..217	CDD:153322	36/230 (16%)
		PH_ACAP	273..369	CDD:270070	30/123 (24%)
		PH	273..365	CDD:278594	29/121 (24%)
		ArfGap	402..520	CDD:279720
		ANK repeat	657..686	CDD:293786
		ANK	658..776	CDD:238125
		Ank_2	660..754	CDD:289560
		ANK repeat	690..721	CDD:293786
		ANK repeat	723..754	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910