DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment step and ADAP2

DIOPT Version :9

Sequence 1:	NP_001036375.2	Gene:	step / 35425	FlyBaseID:	FBgn0086779	Length:	727	Species:	Drosophila melanogaster
Sequence 2:	XP_024306599.1	Gene:	ADAP2 / 55803	HGNCID:	16487	Length:	403	Species:	Homo sapiens

Alignment Length:	154	Identity:	33/154 - (21%)
Similarity:	60/154 - (38%)	Gaps:	34/154 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 DKEGWLWKQGGRYKSWKRRWFIL--NDNCLYYFEYTTDKEPRGIIPLENISVR------------ 645
            ::||:|||:|.....:.||.|:|  .:..|.||.....|.|:.:|.:::::..
Human   134 NREGFLWKRGRDNSQFLRRKFVLLAREGLLKYFTKEQGKSPKAVISIKDLNATFQTEKIGHPHGL 198

  Fly   646 EIHDRSKPHCFELFA--TGGADII------KACKTDSEGKVVEGKHTVYRMSAATEEDQQEWIKR 702
            :|..|...|...||.  ..|.:|:      :|.:..            |...|..|..:.|.:..
Human   199 QITYRRDGHTRNLFVYHESGKEIVDWFNALRAARLQ------------YLKMAFPELPESELVPF 251

  Fly   703 LTQSISHNPFYDILVQRKKKALSK 726
            ||::.....|.:....::|:...|
Human   252 LTRNYLKQGFMEKTGPKQKEPFKK 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680
		PH_GRP1-like	592..710	CDD:269954	30/136 (22%)
		PH	596..708	CDD:278594	30/133 (23%)
ADAP2	XP_024306599.1	ArfGap	8..126	CDD:307528
		PH1_ADAP	133..241	CDD:270072	26/118 (22%)
		PH2_ADAP	255..362	CDD:241282	3/21 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910