Protein Alignment step and pik3r3

DIOPT Version :9

• Sequence 1: NP_001036375.2
• Gene: step / 35425
• FlyBaseID: FBgn0086779
• Length: 727
• Species: Drosophila melanogaster
• Sequence 2: NP_001017229.1
• Gene: pik3r3 / 549983
• XenbaseID: XB-GENE-6464721
• Length: 461
• Species: Xenopus tropicalis
• Alignment Length: 587
• Identity: 100/587 - (17%)
• Similarity: 186/587 - (31%)
• Gaps: 196/587 - (33%)

  Fly   156 MAPYTSVATYNI---TKLAPDSPPPASPTLST-----QTVNCSDVTTKVTEVQRLPCDEPNTELI 212
            |.||::...:.|   ..:.|..||.:..:|||     .:|:..|......::.|   :|.|.:|
 Frog    19 MMPYSTELIFYIEMDPPVLPPKPPKSMTSLSTDGSKENSVSLQDAEWYWGDISR---EEVNDKL- 79

  Fly   213 SKRTEYKHTTITTTTRTLIVSRPVELLLNENGEIIARRSPRKSRSNSLGRMLDVQNEIGTGGLFM 277
               .:....|......:..|.....|.|.:.|.               .:::.:.::.|..|.
 Frog    80 ---RDMPDGTFLVRDASTKVQGDYTLTLRKGGN---------------NKLIKIYHQDGKYGF-- 124

  Fly   278 EADPCSKNSLPP-------------PPYIDDMRFIDDSSNSQSESERNSNIHKTNKYTSKNNNND 329
             :||.:.||:..             .|.:|.......|...|.:..:..||....:...:.:...
 Frog   125 -SDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSRYQQDQLVKEDNIDAVGRKLQEYHGQF 188

  Fly   330 SKRESQQSNLCESCRMLLDRNYINTEQSDNLVILRRPSKQIKDELCEVVSEMEALDVPEDCKHSN 394
            ..:..:...|.|        .|..|.|.   :.::|.:.:..:|..::..        |.| |:
 Frog   189 QDKSKEYDKLYE--------EYTKTSQE---IQMKRTAIEAFNETIKIFE--------EQC-HT- 232

  Fly   395 KDKQMSIGRKKFNMDPKKGIEYLVENRLLRHDPQDVAHFLYKGEGLNKTAIGDYLGEKNDFNEDV 459
            :::......::||   ::|.|..:|..::.::..             |:.:|:....|....:|:
 Frog   233 QERYSKEYMERFN---REGNEKEMERIIMNYEKL-------------KSRLGEIHDSKLRLEQDL 281

  Fly   460 LKAFVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVLSF 524
            .|              |||           :.::||:.|.:......||..          :...
 Frog   282 KK--------------QAL-----------DNREIDKKMNSIKPDLIQLRK----------IRDQ 311

  Fly   525 AIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKIPQDDGNDLMH 589
            .::.||    :..|:.|...|..     ||.|             |:|....|...:||  :|.|
 Frog   312 YLVWLN----HKGVRQKRINDWL-----GIKN-------------ENIDDTYFVSEEDD--NLPH 352

  Fly   590 TFFNPDKEGWLWKQGGRYKSWKRRWFILNDNCLYYFEYTTDKEPRGIIPLENISVREIHDRSKPH 654
                             |.  ::.||:.:.|.:...|..:.|.....:         |.:.||..
 Frog   353 -----------------YD--EKTWFVGDLNRIQAEELLSGKPDGAFL---------IRESSKKG 389

  Fly   655 CFELFATGGADIIKACKTDSEGKVVEGKH-TVYRMSA----ATEEDQQEWIKRL------TQSIS 708
            |:            ||...::|.|   || .:|..|.    |...:....:|.|      |..:.
 Frog   390 CY------------ACSVVADGDV---KHCVIYSTSRGYGFAEPYNLYSTLKELVLHYQHTSLVQ 439

  Fly   709 HN 710
            ||
 Frog   440 HN 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
step	NP_001036375.2	Sec7	397..577	CDD:279680	28/179 (16%)
		PH_GRP1-like	592..710	CDD:269954	22/128 (17%)
		PH	596..708	CDD:278594	22/122 (18%)
pik3r3	NP_001017229.1	SH2_nSH2_p85_like	59..167	CDD:198195	20/132 (15%)
		iSH2_PI3K_IA_R	172..332	CDD:355389	35/240 (15%)
		SH2_cSH2_p85_like	351..454	CDD:198184	25/134 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910